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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ARHGAP36

Summary for ARHGAP36

Gene information	Gene symbol	ARHGAP36
	Ensembl ID	ENSG00000147256
	Entrez ID	158763
	Gene name	Rho GTPase activating protein 36
	Synonyms	FLJ30058
	Gene type	protein_coding
	UniProtAcc	Q6ZRI8

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Dataset with differentially expressed gene: ARHGAP36

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.08866	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	2.57236	0.00e+00

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Expression of ARHGAP36 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARHGAP36

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARHGAP36

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARHGAP36	hsa-miR-660-5p	95.8983	NM_144967
ARHGAP36	hsa-miR-4673	92.2536	NM_144967
ARHGAP36	hsa-miR-4427	92.2025	NM_001282607
ARHGAP36	hsa-miR-890	92.1301	NM_001282607
ARHGAP36	hsa-miR-6729-3p	91.6608	NM_001282607
ARHGAP36	hsa-miR-5683	91.4456	NM_144967
ARHGAP36	hsa-miR-4645-5p	91.3881	NM_144967
ARHGAP36	hsa-miR-5591-3p	89.9495	NM_001282607
ARHGAP36	hsa-miR-9718	89.8027	NM_144967
ARHGAP36	hsa-miR-6791-5p	89.2779	NM_144967
ARHGAP36	hsa-miR-4292	89.2779	NM_144967
ARHGAP36	hsa-miR-6881-5p	88.1336	NM_144967
ARHGAP36	hsa-miR-6728-3p	87.7504	NM_144967
ARHGAP36	hsa-miR-580-5p	87.1354	NM_144967
ARHGAP36	hsa-miR-4719	86.6699	NM_144967
ARHGAP36	hsa-miR-12122	84.9917	NM_144967
ARHGAP36	hsa-miR-511-5p	83.0369	NM_001282607
ARHGAP36	hsa-miR-6739-5p	82.3397	NM_001282607
ARHGAP36	hsa-miR-6733-5p	82.3397	NM_001282607
ARHGAP36	hsa-miR-6862-5p	82.3108	NM_144967
ARHGAP36	hsa-miR-4253	82.3108	NM_144967
ARHGAP36	hsa-miR-7152-5p	81.1496	NM_001282607
ARHGAP36	hsa-miR-2355-5p	81.0367	NM_001282607
ARHGAP36	hsa-miR-628-5p	80.9575	NM_144967

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Motifs and transcription factors (TFs) regulating ARHGAP36

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARHGAP36	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
ARHGAP36	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ARHGAP36	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ARHGAP36	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."