Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ARHGAP35

Summary for ARHGAP35

Gene information	Gene symbol	ARHGAP35
	Ensembl ID	ENSG00000160007
	Entrez ID	2909
	Gene name	Rho GTPase activating protein 35
	Synonyms	GRF-1\|GRLF1\|KIAA1722\|P190A\|p190ARhoGAP\|p190RhoGAP
	Gene type	protein_coding
	UniProtAcc	Q9NRY4

Top

Dataset with differentially expressed gene: ARHGAP35

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.380115	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.347315	5.41e-18
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.326892	2.06e-33

Top

Expression of ARHGAP35 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to ARHGAP35

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating ARHGAP35

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARHGAP35	hsa-miR-6867-5p	99.3546	NM_004491
ARHGAP35	hsa-miR-6512-5p	97.1504	NM_004491
ARHGAP35	hsa-miR-1245b-5p	94.6122	NM_004491
ARHGAP35	hsa-miR-3142	94.5174	NM_004491
ARHGAP35	hsa-miR-587	94.0835	NM_004491
ARHGAP35	hsa-miR-4255	91.8714	NM_004491
ARHGAP35	hsa-miR-4505	90.3186	NM_004491
ARHGAP35	hsa-miR-5787	90.2518	NM_004491
ARHGAP35	hsa-miR-6769a-3p	90.0889	NM_004491
ARHGAP35	hsa-miR-6770-5p	88.0545	NM_004491
ARHGAP35	hsa-miR-7113-5p	86.7934	NM_004491
ARHGAP35	hsa-miR-6768-5p	86.3507	NM_004491
ARHGAP35	hsa-miR-3922-5p	85.5964	NM_004491
ARHGAP35	hsa-miR-888-5p	81.1821	NM_004491
ARHGAP35	hsa-miR-373-5p	81.1504	NM_004491
ARHGAP35	hsa-miR-371b-5p	81.1504	NM_004491
ARHGAP35	hsa-miR-616-5p	81.1504	NM_004491
ARHGAP35	hsa-miR-4326	81.1287	NM_004491
ARHGAP35	hsa-miR-2053	80.7693	NM_004491
ARHGAP35	hsa-miR-5696	80.4321	NM_004491
ARHGAP35	hsa-miR-6783-3p	80.2572	NM_004491
ARHGAP35	hsa-miR-383-3p	80.0854	NM_004491
ARHGAP35	hsa-miR-524-5p	80.0849	NM_004491
ARHGAP35	hsa-miR-520d-5p	80.0849	NM_004491

Page: 1

Top

Motifs and transcription factors (TFs) regulating ARHGAP35

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARHGAP35	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
ARHGAP35	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
ARHGAP35	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."