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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ARHGAP29

Summary for ARHGAP29

Gene information	Gene symbol	ARHGAP29
	Ensembl ID	ENSG00000137962
	Entrez ID	9411
	Gene name	Rho GTPase activating protein 29
	Synonyms	PARG1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ARHGAP29

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.548274	4.41e-43
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.510814	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.810641	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.482156	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.808422	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.858888	0.00e+00

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Expression of ARHGAP29 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARHGAP29

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARHGAP29

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARHGAP29	hsa-miR-5011-5p	99.9144	NM_004815
ARHGAP29	hsa-miR-3163	99.8066	NM_004815
ARHGAP29	hsa-miR-548x-3p	99.3847	NM_004815
ARHGAP29	hsa-miR-548aj-3p	99.3847	NM_004815
ARHGAP29	hsa-miR-8065	99.1857	NM_004815
ARHGAP29	hsa-miR-548ae-3p	98.8592	NM_004815
ARHGAP29	hsa-miR-548aq-3p	98.8592	NM_004815
ARHGAP29	hsa-miR-548j-3p	98.6754	NM_004815
ARHGAP29	hsa-miR-548ah-3p	98.6754	NM_004815
ARHGAP29	hsa-miR-548am-3p	98.6754	NM_004815
ARHGAP29	hsa-miR-190a-3p	97.7039	NM_004815
ARHGAP29	hsa-miR-3662	95.9103	NM_004815
ARHGAP29	hsa-miR-500a-3p	95.8608	NM_004815
ARHGAP29	hsa-miR-548e-5p	94.7648	NM_004815
ARHGAP29	hsa-miR-4316	94.5997	NM_004815
ARHGAP29	hsa-miR-548c-3p	94.5641	NM_004815
ARHGAP29	hsa-miR-548as-3p	93.5644	NM_004815
ARHGAP29	hsa-miR-1250-3p	91.5045	NM_004815
ARHGAP29	hsa-miR-1323	91.1856	NM_004815
ARHGAP29	hsa-miR-4495	90.862	NM_004815
ARHGAP29	hsa-miR-7159-3p	90.4972	NM_004815
ARHGAP29	hsa-miR-513c-3p	90.3427	NM_004815
ARHGAP29	hsa-miR-513a-3p	90.3427	NM_004815
ARHGAP29	hsa-miR-224-3p	88.6831	NM_004815
ARHGAP29	hsa-miR-522-3p	88.6831	NM_004815
ARHGAP29	hsa-miR-92a-2-5p	88.483	NM_004815
ARHGAP29	hsa-miR-6835-3p	88.4009	NM_004815
ARHGAP29	hsa-miR-548o-3p	87.9096	NM_004815
ARHGAP29	hsa-miR-3619-3p	87.3624	NM_004815
ARHGAP29	hsa-miR-1827	87.0513	NM_004815
ARHGAP29	hsa-miR-3606-3p	86.9603	NM_004815
ARHGAP29	hsa-miR-3529-3p	86.6117	NM_004815
ARHGAP29	hsa-miR-494-5p	86.3849	NM_004815
ARHGAP29	hsa-miR-410-5p	86.3849	NM_004815
ARHGAP29	hsa-miR-323b-5p	86.3849	NM_004815
ARHGAP29	hsa-miR-5582-5p	86.1068	NM_004815
ARHGAP29	hsa-miR-4776-5p	85.9011	NM_004815
ARHGAP29	hsa-miR-3672	85.4129	NM_004815
ARHGAP29	hsa-miR-6864-3p	85.4129	NM_004815
ARHGAP29	hsa-miR-548h-3p	84.6422	NM_004815
ARHGAP29	hsa-miR-548z	84.6422	NM_004815
ARHGAP29	hsa-miR-410-3p	83.582	NM_004815
ARHGAP29	hsa-miR-561-3p	83.5665	NM_004815
ARHGAP29	hsa-miR-519a-3p	83.0157	NM_004815
ARHGAP29	hsa-miR-519b-3p	83.0157	NM_004815
ARHGAP29	hsa-miR-519c-3p	83.0157	NM_004815
ARHGAP29	hsa-miR-548bb-3p	82.9756	NM_004815
ARHGAP29	hsa-miR-548ac	82.9366	NM_004815
ARHGAP29	hsa-miR-3190-5p	82.7706	NM_004815
ARHGAP29	hsa-miR-4263	82.6157	NM_004815

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Motifs and transcription factors (TFs) regulating ARHGAP29

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARHGAP29	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
ARHGAP29	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
ARHGAP29	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
ARHGAP29	transfac_pro__M06156	ZNF75D (directAnnotation).
ARHGAP29	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
ARHGAP29	hdpi__FLI1	FLI1 (directAnnotation).
ARHGAP29	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ARHGAP29	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
ARHGAP29	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ARHGAP29	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
ARHGAP29	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
ARHGAP29	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ARHGAP29	transfac_pro__M00652	NRF1 (directAnnotation).
ARHGAP29	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
ARHGAP29	transfac_pro__M04866	HDAC2 (directAnnotation).
ARHGAP29	jaspar__MA1122.1	TFDP1 (directAnnotation).
ARHGAP29	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ARHGAP29	metacluster_135.11	NR2C2 (directAnnotation).
ARHGAP29	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ARHGAP29	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ARHGAP29	metacluster_7.13	ZFX (directAnnotation).
ARHGAP29	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ARHGAP29	cisbp__M00968	MTF2 (directAnnotation).
ARHGAP29	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ARHGAP29	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ARHGAP29	cisbp__M00341	PAX6 (directAnnotation).
ARHGAP29	metacluster_198.3	ZFP64 (directAnnotation).
ARHGAP29	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ARHGAP29	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ARHGAP29	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ARHGAP29	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ARHGAP29	cisbp__M00788	ZFY (inferredBy_Orthology).
ARHGAP29	metacluster_175.1	ZNF283 (directAnnotation).
ARHGAP29	hdpi__ZNF304	ZNF304 (directAnnotation).
ARHGAP29	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ARHGAP29	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ARHGAP29	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ARHGAP29	transfac_pro__M01199	TRIM28 (directAnnotation).
ARHGAP29	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ARHGAP29	metacluster_151.2	ZNF23 (directAnnotation).
ARHGAP29	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ARHGAP29	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ARHGAP29	transfac_pro__M03806	ZBTB7C (directAnnotation).
ARHGAP29	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ARHGAP29	jaspar__MA0502.2	NFYB (directAnnotation).
ARHGAP29	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
ARHGAP29	transfac_pro__M04918	EGR1 (directAnnotation).
ARHGAP29	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
ARHGAP29	cisbp__M01863	ZNF711 (inferredBy_Orthology).
ARHGAP29	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."