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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ARHGAP21

Summary for ARHGAP21

Gene information	Gene symbol	ARHGAP21
	Ensembl ID	ENSG00000107863
	Entrez ID	57584
	Gene name	Rho GTPase activating protein 21
	Synonyms	ARHGAP10\|KIAA1424
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ARHGAP21

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.357403	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.268387	7.04e-37

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Expression of ARHGAP21 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARHGAP21

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARHGAP21

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARHGAP21	hsa-miR-5011-5p	100	NM_020824
ARHGAP21	hsa-miR-190a-3p	99.9218	NM_020824
ARHGAP21	hsa-miR-4742-3p	98.6335	NM_020824
ARHGAP21	hsa-miR-548ar-3p	98.1244	NM_020824
ARHGAP21	hsa-miR-148b-3p	97.1732	NM_020824
ARHGAP21	hsa-miR-148a-3p	97.1732	NM_020824
ARHGAP21	hsa-miR-152-3p	97.1732	NM_020824
ARHGAP21	hsa-miR-548az-3p	96.9023	NM_020824
ARHGAP21	hsa-miR-548e-3p	96.9023	NM_020824
ARHGAP21	hsa-miR-548bc	96.9023	NM_020824
ARHGAP21	hsa-miR-548a-3p	96.9023	NM_020824
ARHGAP21	hsa-miR-548f-3p	96.9023	NM_020824
ARHGAP21	hsa-miR-6504-5p	95.2259	NM_020824
ARHGAP21	hsa-miR-6853-3p	94.9188	NM_020824
ARHGAP21	hsa-miR-6768-5p	94.8317	NM_020824
ARHGAP21	hsa-miR-3085-3p	94.0546	NM_020824
ARHGAP21	hsa-miR-3064-5p	94.0546	NM_020824
ARHGAP21	hsa-miR-194-5p	93.5223	NM_020824
ARHGAP21	hsa-miR-1827	93.5116	NM_020824
ARHGAP21	hsa-miR-4659a-3p	93.2846	NM_020824
ARHGAP21	hsa-miR-4659b-3p	93.2846	NM_020824
ARHGAP21	hsa-miR-199b-5p	93.2691	NM_020824
ARHGAP21	hsa-miR-199a-5p	93.2691	NM_020824
ARHGAP21	hsa-miR-224-5p	92.4688	NM_020824
ARHGAP21	hsa-miR-454-3p	91.815	NM_020824
ARHGAP21	hsa-miR-5582-3p	91.6441	NM_020824
ARHGAP21	hsa-miR-1297	91.2712	NM_020824
ARHGAP21	hsa-miR-3133	91.1953	NM_020824
ARHGAP21	hsa-miR-130b-3p	91.1831	NM_020824
ARHGAP21	hsa-miR-9851-3p	90.9382	NM_020824
ARHGAP21	hsa-miR-183-5p	90.7763	NM_020824
ARHGAP21	hsa-miR-4690-3p	90.5349	NM_020824
ARHGAP21	hsa-miR-5685	90.5349	NM_020824
ARHGAP21	hsa-miR-128-3p	90.4846	NM_020824
ARHGAP21	hsa-miR-216a-3p	90.4846	NM_020824
ARHGAP21	hsa-miR-548g-3p	89.8818	NM_020824
ARHGAP21	hsa-miR-26b-5p	89.4367	NM_020824
ARHGAP21	hsa-miR-26a-5p	89.4367	NM_020824
ARHGAP21	hsa-miR-130a-3p	89.3832	NM_020824
ARHGAP21	hsa-miR-4295	89.3832	NM_020824
ARHGAP21	hsa-miR-301a-3p	89.3832	NM_020824
ARHGAP21	hsa-miR-3666	89.3832	NM_020824
ARHGAP21	hsa-miR-301b-3p	89.3832	NM_020824
ARHGAP21	hsa-miR-4794	89.3542	NM_020824
ARHGAP21	hsa-miR-149-5p	89.3542	NM_020824
ARHGAP21	hsa-miR-19a-3p	89.0225	NM_020824
ARHGAP21	hsa-miR-19b-3p	89.0225	NM_020824
ARHGAP21	hsa-miR-5696	88.924	NM_020824
ARHGAP21	hsa-miR-1825	88.8632	NM_020824
ARHGAP21	hsa-miR-3681-3p	88.846	NM_020824

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Motifs and transcription factors (TFs) regulating ARHGAP21

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARHGAP21	transfac_pro__M07436	WT1 (directAnnotation).
ARHGAP21	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ARHGAP21	transfac_pro__M04916	TAF1 (directAnnotation).
ARHGAP21	metacluster_3.14	WT1; WT1 (directAnnotation).
ARHGAP21	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ARHGAP21	transfac_pro__M02089	E2F3 (directAnnotation).
ARHGAP21	transfac_pro__M07329	SP7 (directAnnotation).
ARHGAP21	transfac_pro__M01122	ZNF219 (directAnnotation).
ARHGAP21	kznf__ZNF311_Imbeault2017_RP_ChIP-seq	ZNF311 (directAnnotation).
ARHGAP21	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
ARHGAP21	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
ARHGAP21	metacluster_44.7	NKX3-2 (directAnnotation).
ARHGAP21	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ARHGAP21	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
ARHGAP21	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
ARHGAP21	transfac_pro__M08819	KLF2 (directAnnotation).
ARHGAP21	transfac_pro__M01175	ZBTB7B (directAnnotation).
ARHGAP21	cisbp__M00249	WT1 (directAnnotation).
ARHGAP21	transfac_pro__M01118	WT1 (directAnnotation).
ARHGAP21	swissregulon__hs__KLF6	KLF6 (directAnnotation).
ARHGAP21	transfac_pro__M01303	SP1 (directAnnotation).
ARHGAP21	transfac_pro__M04595	SALL2 (directAnnotation).
ARHGAP21	tfdimers__MD00483	ZBTB14 (directAnnotation).
ARHGAP21	transfac_pro__M01837	KLF11 (directAnnotation).
ARHGAP21	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ARHGAP21	transfac_pro__M00716	ZBTB14 (directAnnotation).
ARHGAP21	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
ARHGAP21	metacluster_133.2	CPSF4; CPSF4; E2F4; FOXO3; KLF13; KLF15; KLF17; KLF5; MAZ; MAZ; MAZ; MZF1; PATZ1; PATZ1; PATZ1; PATZ1; PLAG1; PRDM9; SP4; VEZF1; WT1; ZBTB17; ZBTB7A; ZBTB7A; ZBTB7B; ZNF148; ZNF148; ZNF148; ZNF148; ZNF180; ZNF180; ZNF202; ZNF219; ZNF219; ZNF263; ZNF263; ZNF28; ZNF281; ZNF281; ZNF281; ZNF281; ZNF281; ZNF383; ZNF398; ZNF398; ZNF444; ZNF444; ZNF467; ZNF543; ZNF543; ZNF641; ZNF692; ZNF737; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF880; ZNF880 (directAnnotation). MAZ; PLAG1; PLAGL1; SP1; SP5; SP5; ZBTB17; ZNF281; ZNF281; ZNF281; ZNF641; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
ARHGAP21	transfac_pro__M07397	ZNF148 (directAnnotation).
ARHGAP21	transfac_pro__M12686	ZBTB10 (directAnnotation).
ARHGAP21	transfac_pro__M00807	EGR1; EGR2; EGR3 (directAnnotation).
ARHGAP21	transfac_pro__M01104	OVOL2 (directAnnotation).
ARHGAP21	transfac_pro__M00986	CHURC1 (directAnnotation).
ARHGAP21	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
ARHGAP21	transfac_pro__M07310	SP5 (directAnnotation).
ARHGAP21	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ARHGAP21	transfac_pro__M03876	ZBTB33 (directAnnotation).
ARHGAP21	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
ARHGAP21	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
ARHGAP21	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ARHGAP21	transfac_pro__M04817	ZBTB33 (directAnnotation).
ARHGAP21	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
ARHGAP21	cisbp__M07938	E2F1 (directAnnotation).
ARHGAP21	cisbp__M00968	MTF2 (directAnnotation).
ARHGAP21	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
ARHGAP21	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
ARHGAP21	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ARHGAP21	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
ARHGAP21	jaspar__MA1122.1	TFDP1 (directAnnotation).
ARHGAP21	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."