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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ARGLU1

Summary for ARGLU1

Gene information	Gene symbol	ARGLU1
	Ensembl ID	ENSG00000134884
	Entrez ID	55082
	Gene name	arginine and glutamate rich 1
	Synonyms	FLJ10154
	Gene type	protein_coding
	UniProtAcc	Q9NWB6

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Dataset with differentially expressed gene: ARGLU1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.687197	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.408357	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.423823	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.336351	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.387596	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.25012	2.67e-06
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.328309	7.74e-15
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.338929	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.402868	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.469309	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.354656	2.27e-43
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-1.70598	1.68e-11
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	CD8+ T cells	-0.28009	1.46e-07
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	Malignant cells	-0.328214	2.73e-13
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	CD8+ T cells	-0.266175	2.69e-03
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	Malignant cells	-0.261709	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.280723	5.06e-33
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.282991	0.00e+00

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Expression of ARGLU1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARGLU1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARGLU1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARGLU1	hsa-miR-545-3p	98.105	NM_018011
ARGLU1	hsa-miR-676-5p	97.7728	NM_018011
ARGLU1	hsa-miR-634	97.5132	NM_018011
ARGLU1	hsa-miR-5000-5p	95.1653	NM_018011
ARGLU1	hsa-miR-6769a-3p	94.792	NM_018011
ARGLU1	hsa-miR-4310	94.4917	NM_018011
ARGLU1	hsa-miR-338-3p	94.3756	NM_018011
ARGLU1	hsa-miR-7157-5p	94.0283	NM_018011
ARGLU1	hsa-miR-548ac	92.8739	NM_018011
ARGLU1	hsa-miR-548z	92.8739	NM_018011
ARGLU1	hsa-miR-548d-3p	92.8739	NM_018011
ARGLU1	hsa-miR-548h-3p	92.8739	NM_018011
ARGLU1	hsa-miR-548bb-3p	92.8739	NM_018011
ARGLU1	hsa-miR-499a-5p	92.6076	NM_018011
ARGLU1	hsa-miR-335-5p	91.5668	NM_018011
ARGLU1	hsa-miR-6844	90.5833	NM_018011
ARGLU1	hsa-miR-5011-5p	90.3048	NM_018011
ARGLU1	hsa-miR-3148	90.2684	NM_018011
ARGLU1	hsa-miR-12136	90.1406	NM_018011
ARGLU1	hsa-miR-4729	90.1032	NM_018011
ARGLU1	hsa-miR-6716-5p	89.9737	NM_018011
ARGLU1	hsa-miR-3658	89.003	NM_018011
ARGLU1	hsa-miR-873-5p	88.7822	NM_018011
ARGLU1	hsa-miR-4457	87.8883	NM_018011
ARGLU1	hsa-miR-4724-5p	87.5429	NM_018011
ARGLU1	hsa-miR-8087	86.2531	NM_018011
ARGLU1	hsa-miR-4533	85.4456	NM_018011
ARGLU1	hsa-miR-361-5p	85.181	NM_018011
ARGLU1	hsa-miR-3180-5p	84.9484	NM_018011
ARGLU1	hsa-miR-524-5p	84.4894	NM_018011
ARGLU1	hsa-miR-520d-5p	84.4894	NM_018011
ARGLU1	hsa-miR-1197	84.4697	NM_018011
ARGLU1	hsa-miR-29b-1-5p	84.181	NM_018011
ARGLU1	hsa-miR-7159-5p	84.0077	NM_018011
ARGLU1	hsa-miR-340-5p	83.8528	NM_018011
ARGLU1	hsa-miR-4797-5p	83.3996	NM_018011
ARGLU1	hsa-miR-548aj-3p	83.1969	NM_018011
ARGLU1	hsa-miR-548x-3p	83.1969	NM_018011
ARGLU1	hsa-miR-3678-3p	83.1747	NM_018011
ARGLU1	hsa-miR-548j-3p	80.8155	NM_018011
ARGLU1	hsa-miR-548am-3p	80.8155	NM_018011
ARGLU1	hsa-miR-548ah-3p	80.8155	NM_018011
ARGLU1	hsa-miR-548aq-3p	80.8155	NM_018011
ARGLU1	hsa-miR-548ae-3p	80.8155	NM_018011
ARGLU1	hsa-miR-4539	80.6537	NM_018011
ARGLU1	hsa-miR-12113	80.6537	NM_018011
ARGLU1	hsa-miR-4699-3p	80.5426	NM_018011
ARGLU1	hsa-miR-421	80.1248	NM_018011

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Motifs and transcription factors (TFs) regulating ARGLU1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARGLU1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
ARGLU1	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
ARGLU1	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
ARGLU1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
ARGLU1	hdpi__ETV4	ETV4 (directAnnotation).
ARGLU1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
ARGLU1	jaspar__MA1483.2	ELF2 (directAnnotation).
ARGLU1	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
ARGLU1	cisbp__M08198	ELF1 (directAnnotation).
ARGLU1	hdpi__TP73	TP73 (directAnnotation).
ARGLU1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
ARGLU1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
ARGLU1	jaspar__MA1460.1	YY1 (inferredBy_Orthology).
ARGLU1	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
ARGLU1	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
ARGLU1	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
ARGLU1	transfac_pro__M06173	ZNF85 (directAnnotation).
ARGLU1	transfac_pro__M00430	E2F1 (directAnnotation).
ARGLU1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ARGLU1	kznf__ZNF343_Imbeault2017_OM_RCADE	ZNF343 (directAnnotation).
ARGLU1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ARGLU1	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
ARGLU1	hdpi__ELF2	ELF2 (directAnnotation).
ARGLU1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
ARGLU1	metacluster_177.7	ZBTB18; ZBTB18; ZBTB18; ZBTB42 (directAnnotation).
ARGLU1	transfac_pro__M12441	ZNF281 (inferredBy_Orthology).
ARGLU1	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
ARGLU1	metacluster_156.3	DBP; DBP; DBP; DBP; DBP; DBP; DBP; DBP; HLF; HLF; HLF; HLF; HLF; HLF; HLF; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; TEF; TEF; TEF; TEF; TEF (directAnnotation). DBP; DBP; DBP; DBP; DBP; HLF; HLF; HLF; HLF; HLF; NFIL3; NFIL3; NFILZ; NFILZ; TEF; TEF; TEF; TEF (inferredBy_Orthology).
ARGLU1	tfdimers__MD00553	FOXG1; FOXO1; RUNX3 (directAnnotation).
ARGLU1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
ARGLU1	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).
ARGLU1	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
ARGLU1	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
ARGLU1	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."