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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ARFRP1

Summary for ARFRP1

Gene information	Gene symbol	ARFRP1
	Ensembl ID	ENSG00000101246
	Entrez ID	10139
	Gene name	ADP ribosylation factor related protein 1
	Synonyms	ARL18\|ARP\|Arp1
	Gene type	protein_coding
	UniProtAcc	Q13795

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Dataset with differentially expressed gene: ARFRP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.297498	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.339356	0.00e+00

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Expression of ARFRP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARFRP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARFRP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARFRP1	hsa-miR-6785-5p	89.2574	NM_003224
ARFRP1	hsa-miR-4728-5p	89.2574	NM_003224
ARFRP1	hsa-miR-149-3p	88.7869	NM_003224
ARFRP1	hsa-miR-340-5p	87.3303	NM_003224
ARFRP1	hsa-miR-4497	87.09	NM_001267549
ARFRP1	hsa-miR-6883-5p	84.1676	NM_003224
ARFRP1	hsa-miR-548aq-5p	81.6769	NM_001267544
ARFRP1	hsa-miR-548d-5p	81.6769	NM_001267544
ARFRP1	hsa-miR-548ab	81.6769	NM_001267544
ARFRP1	hsa-miR-548o-5p	81.6769	NM_001267544
ARFRP1	hsa-miR-548ay-5p	81.6769	NM_001267544
ARFRP1	hsa-miR-548j-5p	81.6769	NM_001267544
ARFRP1	hsa-miR-548y	81.6769	NM_001267544
ARFRP1	hsa-miR-548ak	81.6769	NM_001267544
ARFRP1	hsa-miR-548bb-5p	81.6769	NM_001267544
ARFRP1	hsa-miR-548a-5p	81.6769	NM_001267544
ARFRP1	hsa-miR-548ae-5p	81.6769	NM_001267544
ARFRP1	hsa-miR-548ad-5p	81.6769	NM_001267544
ARFRP1	hsa-miR-548am-5p	81.6769	NM_001267544
ARFRP1	hsa-miR-548w	81.6769	NM_001267544
ARFRP1	hsa-miR-548as-5p	81.6769	NM_001267544
ARFRP1	hsa-miR-548au-5p	81.6769	NM_001267544
ARFRP1	hsa-miR-548i	81.6769	NM_001267544
ARFRP1	hsa-miR-548b-5p	81.6769	NM_001267544
ARFRP1	hsa-miR-548c-5p	81.6769	NM_001267544
ARFRP1	hsa-miR-548h-5p	81.6769	NM_001267544
ARFRP1	hsa-miR-548ar-5p	81.6769	NM_001267544
ARFRP1	hsa-miR-559	81.6769	NM_001267544
ARFRP1	hsa-miR-548ap-5p	81.6769	NM_001267544
ARFRP1	hsa-miR-3180-5p	81.5115	NM_003224

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Motifs and transcription factors (TFs) regulating ARFRP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARFRP1	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
ARFRP1	cisbp__M02645	ETS1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."