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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ARFGEF3

Summary for ARFGEF3

Gene information	Gene symbol	ARFGEF3
	Ensembl ID	ENSG00000112379
	Entrez ID	57221
	Gene name	ARFGEF family member 3
	Synonyms	BIG3\|C6orf92\|dJ171N11.1\|KIAA1244\|PPP1R33
	Gene type	protein_coding
	UniProtAcc	Q5TH69

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Dataset with differentially expressed gene: ARFGEF3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	3.09491	5.15e-10
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.767711	0.00e+00

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Expression of ARFGEF3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARFGEF3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARFGEF3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARFGEF3	hsa-miR-548bb-3p	99.4728	NM_020340
ARFGEF3	hsa-miR-548d-3p	99.4728	NM_020340
ARFGEF3	hsa-miR-548z	99.4728	NM_020340
ARFGEF3	hsa-miR-548ac	99.4728	NM_020340
ARFGEF3	hsa-miR-548h-3p	99.4728	NM_020340
ARFGEF3	hsa-miR-3662	99.026	NM_020340
ARFGEF3	hsa-miR-3163	98.1765	NM_020340
ARFGEF3	hsa-miR-4668-5p	97.7053	NM_020340
ARFGEF3	hsa-miR-4691-5p	97.0479	NM_020340
ARFGEF3	hsa-miR-6792-3p	97.0479	NM_020340
ARFGEF3	hsa-miR-3680-3p	96.8582	NM_020340
ARFGEF3	hsa-miR-2110	96.3271	NM_020340
ARFGEF3	hsa-miR-4711-3p	95.3421	NM_020340
ARFGEF3	hsa-miR-670-5p	95.1344	NM_020340
ARFGEF3	hsa-miR-6739-5p	92.6045	NM_020340
ARFGEF3	hsa-miR-6733-5p	92.6045	NM_020340
ARFGEF3	hsa-miR-4775	92.3851	NM_020340
ARFGEF3	hsa-miR-3153	92.2419	NM_020340
ARFGEF3	hsa-miR-190a-3p	92.168	NM_020340
ARFGEF3	hsa-miR-200a-3p	91.6165	NM_020340
ARFGEF3	hsa-miR-141-3p	91.6165	NM_020340
ARFGEF3	hsa-miR-1252-3p	91.1335	NM_020340
ARFGEF3	hsa-miR-5011-5p	91.1038	NM_020340
ARFGEF3	hsa-miR-548x-3p	91.0435	NM_020340
ARFGEF3	hsa-miR-548aj-3p	91.0435	NM_020340
ARFGEF3	hsa-miR-520d-5p	90.9054	NM_020340
ARFGEF3	hsa-miR-568	90.8815	NM_020340
ARFGEF3	hsa-miR-6780b-5p	90.8153	NM_020340
ARFGEF3	hsa-miR-4725-3p	90.8153	NM_020340
ARFGEF3	hsa-miR-4659a-3p	90.6953	NM_020340
ARFGEF3	hsa-miR-4659b-3p	90.6953	NM_020340
ARFGEF3	hsa-miR-524-5p	90.5212	NM_020340
ARFGEF3	hsa-miR-4251	90.4402	NM_020340
ARFGEF3	hsa-miR-4799-5p	90.0689	NM_020340
ARFGEF3	hsa-miR-548j-3p	89.6557	NM_020340
ARFGEF3	hsa-miR-548ah-3p	89.6557	NM_020340
ARFGEF3	hsa-miR-548am-3p	89.6557	NM_020340
ARFGEF3	hsa-miR-548aq-3p	89.6557	NM_020340
ARFGEF3	hsa-miR-548ae-3p	89.6557	NM_020340
ARFGEF3	hsa-miR-8068	89.467	NM_020340
ARFGEF3	hsa-miR-4271	88.9836	NM_020340
ARFGEF3	hsa-miR-6839-5p	88.6971	NM_020340
ARFGEF3	hsa-miR-345-3p	87.8904	NM_020340
ARFGEF3	hsa-miR-628-3p	87.7627	NM_020340
ARFGEF3	hsa-miR-4481	87.4285	NM_020340
ARFGEF3	hsa-miR-513a-3p	87.274	NM_020340
ARFGEF3	hsa-miR-513c-3p	87.274	NM_020340
ARFGEF3	hsa-miR-378j	87.0312	NM_020340
ARFGEF3	hsa-miR-3124-3p	86.6976	NM_020340
ARFGEF3	hsa-miR-548t-3p	86.3151	NM_020340

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Motifs and transcription factors (TFs) regulating ARFGEF3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARFGEF3	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
ARFGEF3	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
ARFGEF3	transfac_pro__M04617	ZBTB7A (directAnnotation).
ARFGEF3	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ARFGEF3	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
ARFGEF3	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ARFGEF3	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ARFGEF3	transfac_pro__M07387	ZBTB7A (directAnnotation).
ARFGEF3	transfac_pro__M07436	WT1 (directAnnotation).
ARFGEF3	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ARFGEF3	transfac_pro__M00716	ZBTB14 (directAnnotation).
ARFGEF3	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ARFGEF3	hdpi__HIP2	UBE2K (directAnnotation).
ARFGEF3	transfac_pro__M04893	TAF1 (directAnnotation).
ARFGEF3	transfac_pro__M03876	ZBTB33 (directAnnotation).
ARFGEF3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ARFGEF3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ARFGEF3	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ARFGEF3	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
ARFGEF3	transfac_pro__M02089	E2F3 (directAnnotation).
ARFGEF3	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
ARFGEF3	transfac_pro__M04817	ZBTB33 (directAnnotation).
ARFGEF3	metacluster_143.13	ZBTB7A (directAnnotation).
ARFGEF3	tfdimers__MD00483	ZBTB14 (directAnnotation).
ARFGEF3	cisbp__M07938	E2F1 (directAnnotation).
ARFGEF3	cisbp__M00968	MTF2 (directAnnotation).
ARFGEF3	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
ARFGEF3	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
ARFGEF3	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ARFGEF3	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
ARFGEF3	jaspar__MA1122.1	TFDP1 (directAnnotation).
ARFGEF3	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."