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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ARFGEF2

Summary for ARFGEF2

Gene information	Gene symbol	ARFGEF2
	Ensembl ID	ENSG00000124198
	Entrez ID	10564
	Gene name	ADP ribosylation factor guanine nucleotide exchange factor 2
	Synonyms	BIG2
	Gene type	protein_coding
	UniProtAcc	Q9Y6D5

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Dataset with differentially expressed gene: ARFGEF2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.796666	6.15e-05
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.327089	0.00e+00

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Expression of ARFGEF2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARFGEF2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARFGEF2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARFGEF2	hsa-miR-9-5p	99.8001	NM_006420
ARFGEF2	hsa-miR-4282	99.2064	NM_006420
ARFGEF2	hsa-miR-335-3p	98.6029	NM_006420
ARFGEF2	hsa-miR-590-3p	98.2835	NM_006420
ARFGEF2	hsa-miR-3180-5p	97.621	NM_006420
ARFGEF2	hsa-miR-561-5p	97.2309	NM_006420
ARFGEF2	hsa-miR-1185-1-3p	96.2003	NM_006420
ARFGEF2	hsa-miR-1185-2-3p	96.2003	NM_006420
ARFGEF2	hsa-let-7f-2-3p	96.1106	NM_006420
ARFGEF2	hsa-miR-376c-3p	94.3467	NM_006420
ARFGEF2	hsa-miR-196a-1-3p	94.1216	NM_006420
ARFGEF2	hsa-let-7b-3p	93.3583	NM_006420
ARFGEF2	hsa-let-7a-3p	93.3583	NM_006420
ARFGEF2	hsa-miR-98-3p	93.3583	NM_006420
ARFGEF2	hsa-let-7f-1-3p	93.3583	NM_006420
ARFGEF2	hsa-miR-4789-5p	93.3583	NM_006420
ARFGEF2	hsa-miR-1299	92.8098	NM_006420
ARFGEF2	hsa-miR-302c-5p	92.6495	NM_006420
ARFGEF2	hsa-miR-6844	91.6052	NM_006420
ARFGEF2	hsa-miR-4451	91.5743	NM_006420
ARFGEF2	hsa-miR-466	90.2512	NM_006420
ARFGEF2	hsa-miR-124-3p	89.9174	NM_006420
ARFGEF2	hsa-miR-506-3p	89.9174	NM_006420
ARFGEF2	hsa-miR-633	89.5977	NM_006420
ARFGEF2	hsa-miR-4325	89.3724	NM_006420
ARFGEF2	hsa-miR-4289	88.8806	NM_006420
ARFGEF2	hsa-miR-2115-3p	88.1831	NM_006420
ARFGEF2	hsa-miR-488-5p	87.7734	NM_006420
ARFGEF2	hsa-let-7c-3p	87.7184	NM_006420
ARFGEF2	hsa-miR-3529-3p	86.876	NM_006420
ARFGEF2	hsa-miR-12119	86.7477	NM_006420
ARFGEF2	hsa-miR-6499-3p	86.4388	NM_006420
ARFGEF2	hsa-miR-6815-5p	86.11	NM_006420
ARFGEF2	hsa-miR-6865-5p	86.11	NM_006420
ARFGEF2	hsa-miR-4422	85.3946	NM_006420
ARFGEF2	hsa-miR-5582-3p	84.8315	NM_006420
ARFGEF2	hsa-miR-875-3p	84.3805	NM_006420
ARFGEF2	hsa-miR-7856-5p	83.9772	NM_006420
ARFGEF2	hsa-miR-659-3p	83.5237	NM_006420
ARFGEF2	hsa-miR-29b-2-5p	83.3462	NM_006420
ARFGEF2	hsa-miR-1276	81.8903	NM_006420
ARFGEF2	hsa-miR-5007-3p	81.5762	NM_006420
ARFGEF2	hsa-miR-548c-3p	81.5138	NM_006420
ARFGEF2	hsa-miR-330-3p	81.4902	NM_006420
ARFGEF2	hsa-miR-4790-3p	81.1686	NM_006420
ARFGEF2	hsa-miR-3153	80.685	NM_006420
ARFGEF2	hsa-miR-1250-3p	80.0802	NM_006420

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Motifs and transcription factors (TFs) regulating ARFGEF2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARFGEF2	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
ARFGEF2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
ARFGEF2	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
ARFGEF2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ARFGEF2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ARFGEF2	metacluster_151.2	ZNF23 (directAnnotation).
ARFGEF2	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
ARFGEF2	jaspar__MA0748.2	YY2 (directAnnotation).
ARFGEF2	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
ARFGEF2	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."