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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ARF3

Summary for ARF3

Gene information	Gene symbol	ARF3
	Ensembl ID	ENSG00000134287
	Entrez ID	377
	Gene name	ADP ribosylation factor 3
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P61204

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Dataset with differentially expressed gene: ARF3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.363634	5.19e-25
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.397078	3.42e-24
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.404478	3.44e-33

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Expression of ARF3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARF3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARF3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARF3	hsa-miR-6716-5p	96.5317	NM_001659
ARF3	hsa-miR-9985	93.5458	NM_001659
ARF3	hsa-miR-27b-3p	93.5458	NM_001659
ARF3	hsa-miR-27a-3p	93.5458	NM_001659
ARF3	hsa-miR-8485	92.8329	NM_001659
ARF3	hsa-miR-6721-5p	92.3686	NM_001659
ARF3	hsa-miR-4306	92.3601	NM_001659
ARF3	hsa-miR-8055	92.2758	NM_001659
ARF3	hsa-miR-6808-5p	92.1036	NM_001659
ARF3	hsa-miR-1-3p	91.2252	NM_001659
ARF3	hsa-miR-206	91.2252	NM_001659
ARF3	hsa-miR-5000-3p	90.9843	NM_001659
ARF3	hsa-miR-6893-5p	89.8866	NM_001659
ARF3	hsa-miR-940	89.8866	NM_001659
ARF3	hsa-miR-613	89.7043	NM_001659
ARF3	hsa-miR-3120-3p	88.9791	NM_001659
ARF3	hsa-miR-5186	88.0057	NM_001659
ARF3	hsa-miR-92a-2-5p	87.2921	NM_001659
ARF3	hsa-miR-7113-5p	87.0612	NM_001659
ARF3	hsa-miR-6766-5p	86.9986	NM_001659
ARF3	hsa-miR-6756-5p	86.9986	NM_001659
ARF3	hsa-miR-6758-5p	86.9417	NM_001659
ARF3	hsa-miR-6856-5p	86.6948	NM_001659
ARF3	hsa-miR-4436a	86.5822	NM_001659
ARF3	hsa-miR-4441	86.2189	NM_001659
ARF3	hsa-miR-4802-3p	86.1295	NM_001659
ARF3	hsa-miR-185-5p	85.4491	NM_001659
ARF3	hsa-miR-4644	85.4491	NM_001659
ARF3	hsa-miR-4481	85.1968	NM_001659
ARF3	hsa-miR-6830-5p	84.5249	NM_001659
ARF3	hsa-miR-216a-3p	84.3863	NM_001659
ARF3	hsa-miR-128-3p	84.3863	NM_001659
ARF3	hsa-miR-4733-5p	83.6969	NM_001659
ARF3	hsa-miR-12136	83.5644	NM_001659
ARF3	hsa-miR-3646	83.1913	NM_001659
ARF3	hsa-miR-3154	82.8767	NM_001659
ARF3	hsa-miR-651-3p	82.8759	NM_001659
ARF3	hsa-miR-3681-3p	82.5202	NM_001659
ARF3	hsa-miR-4745-5p	82.4569	NM_001659
ARF3	hsa-miR-6796-5p	81.763	NM_001659
ARF3	hsa-miR-6511b-3p	81.6926	NM_001659
ARF3	hsa-miR-6511a-3p	81.6926	NM_001659
ARF3	hsa-miR-4261	81.6299	NM_001659
ARF3	hsa-miR-6862-5p	80.3516	NM_001659
ARF3	hsa-miR-4253	80.3516	NM_001659

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Motifs and transcription factors (TFs) regulating ARF3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARF3	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ARF3	cisbp__M00341	PAX6 (directAnnotation).
ARF3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ARF3	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ARF3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ARF3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ARF3	transfac_pro__M03806	ZBTB7C (directAnnotation).
ARF3	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
ARF3	cisbp__M00249	WT1 (directAnnotation).
ARF3	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
ARF3	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
ARF3	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."