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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: AQP4

Summary for AQP4

Gene information	Gene symbol	AQP4
	Ensembl ID	ENSG00000171885
	Entrez ID	361
	Gene name	aquaporin 4
	Synonyms	AQP-4\|hAQP4\|MIWC
	Gene type	protein_coding
	UniProtAcc	P55087

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Dataset with differentially expressed gene: AQP4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	1.01601	2.32e-26

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Expression of AQP4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AQP4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AQP4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AQP4	hsa-miR-548az-5p	98.6862	NM_001317384
AQP4	hsa-miR-548t-5p	98.6862	NM_001317384
AQP4	hsa-miR-4533	97.9068	NM_001317387
AQP4	hsa-miR-7-2-3p	97.5269	NM_001317387
AQP4	hsa-miR-7-1-3p	97.5269	NM_001317387
AQP4	hsa-miR-203a-3p	97.0338	NM_001317384
AQP4	hsa-miR-3143	96.7606	NM_001317384
AQP4	hsa-miR-576-5p	96.3508	NM_001317387
AQP4	hsa-miR-4735-5p	94.6802	NM_001317387
AQP4	hsa-miR-33a-3p	94.6282	NM_001317384
AQP4	hsa-miR-543	93.4996	NM_001317384
AQP4	hsa-miR-5688	93.1288	NM_001317387
AQP4	hsa-miR-4307	92.7413	NM_001317384
AQP4	hsa-miR-3123	92.4697	NM_001317387
AQP4	hsa-miR-4729	92.4421	NM_001317387
AQP4	hsa-miR-331-5p	91.6354	NM_001317384
AQP4	hsa-miR-577	91.4561	NM_001317384
AQP4	hsa-miR-6830-3p	91.3942	NM_001317384
AQP4	hsa-miR-495-3p	91.287	NM_001317387
AQP4	hsa-miR-4288	90.8202	NM_001317387
AQP4	hsa-miR-196a-5p	90.5752	NM_001317387
AQP4	hsa-miR-196b-5p	90.5752	NM_001317387
AQP4	hsa-miR-548ah-5p	89.8868	NM_001317384
AQP4	hsa-miR-3609	89.8868	NM_001317384
AQP4	hsa-miR-4670-3p	89.7245	NM_001317384
AQP4	hsa-miR-3140-3p	89.4129	NM_001317387
AQP4	hsa-miR-6505-5p	89.3944	NM_001317384
AQP4	hsa-miR-4762-5p	89.271	NM_001317387
AQP4	hsa-miR-503-3p	88.1615	NM_001317384
AQP4	hsa-miR-8070	88.0607	NM_001317384
AQP4	hsa-miR-4760-3p	88.0062	NM_001317384
AQP4	hsa-miR-6718-5p	87.8713	NM_001317387
AQP4	hsa-miR-203b-5p	87.8713	NM_001317387
AQP4	hsa-miR-450b-5p	87.7607	NM_001317384
AQP4	hsa-miR-664b-3p	87.7354	NM_001317387
AQP4	hsa-miR-3119	87.5533	NM_001317384
AQP4	hsa-miR-6074	87.3311	NM_001317384
AQP4	hsa-miR-3065-5p	86.5583	NM_001317387
AQP4	hsa-miR-582-5p	86.4274	NM_001317384
AQP4	hsa-miR-4297	86.2082	NM_001317384
AQP4	hsa-miR-3689a-5p	85.7085	NM_001317384
AQP4	hsa-miR-3689e	85.7085	NM_001317384
AQP4	hsa-miR-3689f	85.7085	NM_001317384
AQP4	hsa-miR-3689b-5p	85.7085	NM_001317384
AQP4	hsa-miR-5692a	85.3464	NM_001317384
AQP4	hsa-miR-6787-3p	85.3002	NM_001317384
AQP4	hsa-miR-558	85.2759	NM_001317384
AQP4	hsa-miR-579-3p	84.9563	NM_001317387
AQP4	hsa-miR-4506	84.5216	NM_001317387
AQP4	hsa-miR-548c-3p	84.2769	NM_001317384

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Motifs and transcription factors (TFs) regulating AQP4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AQP4	kznf__ZNF846_Imbeault2017_OM_MEME	ZNF846 (directAnnotation).
AQP4	transfac_pro__M06609	ZKSCAN4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."