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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: AQP3

Summary for AQP3

Gene information	Gene symbol	AQP3
	Ensembl ID	ENSG00000165272
	Entrez ID	360
	Gene name	aquaporin 3 (Gill blood group)
	Synonyms	GIL
	Gene type	protein_coding
	UniProtAcc	Q92482

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Dataset with differentially expressed gene: AQP3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	2.15144	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	0.628226	4.87e-09
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Plasma cells	0.420517	1.12e-02
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	0.600947	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.555729	6.28e-36
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	CD4+ T cells	0.339394	1.04e-38
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	1.20269	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.429668	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	0.489724	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.310676	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.390005	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	0.392342	8.33e-09
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.401758	1.71e-12
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.474044	2.30e-09
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.660351	1.22e-09
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.631228	5.75e-33
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.397815	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	-0.730696	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.12667	0.00e+00

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Expression of AQP3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AQP3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AQP3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AQP3	hsa-miR-548n	96.6295	NM_004925
AQP3	hsa-miR-3163	94.0546	NM_004925
AQP3	hsa-miR-8485	91.9383	NM_004925
AQP3	hsa-miR-4423-3p	90.8127	NM_001318144
AQP3	hsa-miR-5582-5p	90.0555	NM_001318144
AQP3	hsa-miR-548am-5p	87.237	NM_004925
AQP3	hsa-miR-548i	87.237	NM_004925
AQP3	hsa-miR-548o-5p	87.237	NM_004925
AQP3	hsa-miR-548ay-5p	87.237	NM_004925
AQP3	hsa-miR-548aq-5p	87.237	NM_004925
AQP3	hsa-miR-548as-5p	87.237	NM_004925
AQP3	hsa-miR-548ar-5p	87.237	NM_004925
AQP3	hsa-miR-548w	87.237	NM_004925
AQP3	hsa-miR-548d-5p	87.237	NM_004925
AQP3	hsa-miR-548c-5p	87.237	NM_004925
AQP3	hsa-miR-548ab	87.237	NM_004925
AQP3	hsa-miR-548ae-5p	87.237	NM_004925
AQP3	hsa-miR-548b-5p	87.237	NM_004925
AQP3	hsa-miR-548j-5p	87.237	NM_004925
AQP3	hsa-miR-548y	87.237	NM_004925
AQP3	hsa-miR-548au-5p	87.237	NM_004925
AQP3	hsa-miR-548ad-5p	87.237	NM_004925
AQP3	hsa-miR-548ap-5p	87.237	NM_004925
AQP3	hsa-miR-548ak	87.237	NM_004925
AQP3	hsa-miR-548bb-5p	87.237	NM_004925
AQP3	hsa-miR-559	87.237	NM_004925
AQP3	hsa-miR-548h-5p	87.237	NM_004925
AQP3	hsa-miR-548a-5p	87.237	NM_004925
AQP3	hsa-miR-221-3p	86.3207	NM_001318144
AQP3	hsa-miR-222-3p	86.3207	NM_001318144
AQP3	hsa-miR-4293	83.8879	NM_001318144
AQP3	hsa-miR-548t-5p	83.4958	NM_004925
AQP3	hsa-miR-548az-5p	83.4958	NM_004925

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Motifs and transcription factors (TFs) regulating AQP3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AQP3	metacluster_14.28	CLOCK (inferredBy_Orthology).
AQP3	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
AQP3	metacluster_10.17	ARNT (inferredBy_Orthology).
AQP3	homer__NVCACGTG_NPAS	NPAS2 (inferredBy_Orthology).
AQP3	cisbp__M05832	MAX (directAnnotation).
AQP3	transfac_pro__M05605	GATA6 (inferredBy_Orthology).
AQP3	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
AQP3	hocomoco__MXI1_MOUSE.H11MO.1.A	MXI1 (inferredBy_Orthology).
AQP3	taipale_cyt_meth__MLX_NCAYGTGN_eDBD_meth	MLX (directAnnotation).
AQP3	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
AQP3	transfac_pro__M04844	MAX (directAnnotation).
AQP3	flyfactorsurvey__Max_Mnt_SANGER_5_FBgn0017578	MAX (inferredBy_Orthology).
AQP3	dbtfbs__MLX_HepG2_ENCSR125DAD_merged_N1	MLX (directAnnotation).
AQP3	transfac_pro__M01116	ARNTL; ARNTL2 (directAnnotation).
AQP3	metacluster_10.30	MXI1 (inferredBy_Orthology).
AQP3	metacluster_10.46	MAX (inferredBy_Orthology).
AQP3	transfac_pro__M06042	ZNF208 (directAnnotation).
AQP3	metacluster_112.5	HOXA4; PAX3; PAX7; PAX7 (directAnnotation).
AQP3	metacluster_141.2	E2F2; E2F3 (directAnnotation).
AQP3	taipale_tf_pairs__ETV5_CEBPD_NSCGGANNTTRCGYAAN_CAP	CEBPD; ETV5 (directAnnotation).
AQP3	hdpi__TP73	TP73 (directAnnotation).
AQP3	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
AQP3	transfac_pro__M05984	ZNF586 (directAnnotation).
AQP3	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
AQP3	transfac_pro__M06833	PEG3 (directAnnotation).
AQP3	dbtfbs__WT1_HEK293_ENCSR966PJJ_merged_N1	WT1 (directAnnotation).
AQP3	taipale_tf_pairs__HOXB2_SPDEF_ANCCGGATNNNNNNMATTA_CAP_repr	HOXB2; SPDEF (directAnnotation).
AQP3	jaspar__MA1963.1	SATB1 (directAnnotation).
AQP3	metacluster_29.2	BCL6; IRF3; IRF3; STAT1; STAT1; STAT1; STAT2; STAT3; STAT3; STAT3; STAT4; STAT4; STAT5A; STAT5A; STAT5A; STAT5A; STAT5B; STAT5B; STAT5B; STAT6 (directAnnotation). STAT3; STAT5A; STAT5A; STAT5A; STAT5A; STAT5A; STAT5B; STAT5B; STAT6; STAT6 (inferredBy_Orthology).
AQP3	tfdimers__MD00593	GABPA; PITX3 (directAnnotation).
AQP3	tfdimers__MD00410	HMGA1; HMGA2; KLF4 (directAnnotation).
AQP3	taipale_tf_pairs__GCM1_ELF1_NRCCCRNNCGGAAGNN_CAP_repr	ELF1; GCM1 (directAnnotation).
AQP3	transfac_pro__M05770	ZNF77 (directAnnotation).
AQP3	metacluster_22.37	BACH1 (directAnnotation).
AQP3	metacluster_22.39	NFE2L2 (directAnnotation).
AQP3	transfac_pro__M06117	ZNF23 (directAnnotation).
AQP3	metacluster_155.30	ZNF254 (directAnnotation).
AQP3	transfac_pro__M07260	IKZF1 (directAnnotation).
AQP3	hocomoco__PATZ1_HUMAN.H11MO.1.C	PATZ1 (directAnnotation).
AQP3	transfac_pro__M05543	ZSCAN12 (inferredBy_Orthology).
AQP3	transfac_pro__M06816	ZNF263 (inferredBy_Orthology).
AQP3	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
AQP3	transfac_pro__M05354	ZNF800 (inferredBy_Orthology).
AQP3	transfac_pro__M06177	ZNF41 (directAnnotation).
AQP3	metacluster_95.2	ZNF778 (directAnnotation).
AQP3	jaspar__MA1934.1	FIGLA (directAnnotation).
AQP3	transfac_pro__M05718	ZNF30 (directAnnotation).
AQP3	transfac_pro__M06015	ZNF729 (directAnnotation).
AQP3	tfdimers__MD00388	LEF1; NKX3-2; TCF7; TCF7L1 (directAnnotation).
AQP3	taipale_tf_pairs__ETV2_EOMES_RCCGGANNNNNNNNNNNACACCTN_CAP_repr	EOMES; ETV2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
AQP3	"Bisacodyl"	DB09020	small molecule
AQP3	"Sennosides"	DB11365	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."