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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: APOLD1

Summary for APOLD1

Gene information	Gene symbol	APOLD1
	Ensembl ID	ENSG00000178878
	Entrez ID	81575
	Gene name	apolipoprotein L domain containing 1
	Synonyms	DKFZP434F0318\|FLJ25138
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: APOLD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.581628	3.87e-02
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.56178	0.00e+00

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Expression of APOLD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to APOLD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating APOLD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
APOLD1	hsa-miR-7110-3p	99.322	NM_030817
APOLD1	hsa-miR-5692a	98.9159	NM_001130415
APOLD1	hsa-miR-3662	93.5112	NM_030817
APOLD1	hsa-miR-1305	92.7319	NM_030817
APOLD1	hsa-miR-4723-3p	91.4169	NM_030817
APOLD1	hsa-miR-221-3p	90.2168	NM_030817
APOLD1	hsa-miR-222-3p	90.2168	NM_030817
APOLD1	hsa-miR-6769b-3p	89.4056	NM_030817
APOLD1	hsa-miR-3183	89.4056	NM_030817
APOLD1	hsa-miR-516a-3p	88.4349	NM_030817
APOLD1	hsa-miR-516b-3p	88.4349	NM_030817
APOLD1	hsa-miR-7162-5p	88.4349	NM_030817
APOLD1	hsa-miR-516b-5p	87.7843	NM_030817
APOLD1	hsa-miR-4278	87.2692	NM_030817
APOLD1	hsa-miR-4493	86.3762	NM_030817
APOLD1	hsa-miR-5585-5p	85.7887	NM_030817
APOLD1	hsa-miR-187-5p	85.6458	NM_030817
APOLD1	hsa-miR-216a-3p	85.4814	NM_030817
APOLD1	hsa-miR-128-3p	85.4814	NM_030817
APOLD1	hsa-miR-8068	84.9555	NM_030817
APOLD1	hsa-miR-4724-3p	84.5978	NM_001130415
APOLD1	hsa-miR-3163	84.5465	NM_001130415
APOLD1	hsa-miR-3681-3p	83.49	NM_030817
APOLD1	hsa-miR-4313	83.0249	NM_001130415
APOLD1	hsa-miR-6794-5p	82.8624	NM_030817
APOLD1	hsa-miR-4716-3p	82.8624	NM_030817
APOLD1	hsa-miR-378j	82.8548	NM_030817
APOLD1	hsa-miR-5093	81.7884	NM_030817
APOLD1	hsa-miR-6839-5p	81.7332	NM_030817
APOLD1	hsa-miR-3605-5p	80.9068	NM_030817
APOLD1	hsa-miR-548v	80.1161	NM_030817
APOLD1	hsa-miR-4799-5p	80.0855	NM_030817

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Motifs and transcription factors (TFs) regulating APOLD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
APOLD1	metacluster_151.2	ZNF23 (directAnnotation).
APOLD1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."