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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: APOL6

Summary for APOL6

Gene information	Gene symbol	APOL6
	Ensembl ID	ENSG00000221963
	Entrez ID	80830
	Gene name	apolipoprotein L6
	Synonyms	APOL-VI\|APOLVI
	Gene type	protein_coding
	UniProtAcc	Q9BWW8

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Dataset with differentially expressed gene: APOL6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	-0.360477	0.00e+00
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	post	Mono/Macro	-0.288299	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.616425	7.66e-08
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.474735	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.468661	0.00e+00

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Expression of APOL6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to APOL6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating APOL6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
APOL6	hsa-miR-5688	99.0463	NM_030641
APOL6	hsa-miR-495-3p	99.0253	NM_030641
APOL6	hsa-miR-4503	95.6064	NM_030641
APOL6	hsa-miR-3163	94.5962	NM_030641
APOL6	hsa-miR-6780a-5p	94.4185	NM_030641
APOL6	hsa-miR-3162-5p	94.3959	NM_030641
APOL6	hsa-miR-590-3p	93.6384	NM_030641
APOL6	hsa-miR-6867-5p	93.5757	NM_030641
APOL6	hsa-miR-218-1-3p	91.4242	NM_030641
APOL6	hsa-miR-4303	90.7198	NM_030641
APOL6	hsa-miR-5011-5p	90.3503	NM_030641
APOL6	hsa-miR-3117-3p	90.3031	NM_030641
APOL6	hsa-miR-6751-3p	89.5788	NM_030641
APOL6	hsa-miR-1199-5p	89.5788	NM_030641
APOL6	hsa-miR-6779-5p	89.4605	NM_030641
APOL6	hsa-miR-7106-5p	88.1478	NM_030641
APOL6	hsa-miR-3689c	88.1314	NM_030641
APOL6	hsa-miR-30b-3p	88.1314	NM_030641
APOL6	hsa-miR-1273h-5p	88.1314	NM_030641
APOL6	hsa-miR-3689a-3p	88.1314	NM_030641
APOL6	hsa-miR-3689b-3p	88.1314	NM_030641
APOL6	hsa-miR-7977	87.4076	NM_030641
APOL6	hsa-miR-4709-3p	86.293	NM_030641
APOL6	hsa-miR-3613-3p	85.9501	NM_030641
APOL6	hsa-miR-616-5p	85.752	NM_030641
APOL6	hsa-miR-373-5p	85.752	NM_030641
APOL6	hsa-miR-371b-5p	85.752	NM_030641
APOL6	hsa-miR-4297	85.6803	NM_030641
APOL6	hsa-miR-4728-5p	85.2314	NM_030641
APOL6	hsa-miR-561-3p	84.8835	NM_030641
APOL6	hsa-miR-7152-5p	83.849	NM_030641
APOL6	hsa-miR-5580-3p	83.6744	NM_030641
APOL6	hsa-miR-12132	83.6575	NM_030641
APOL6	hsa-miR-548p	83.4718	NM_030641
APOL6	hsa-miR-548ar-3p	83.4006	NM_030641
APOL6	hsa-miR-661	83.3781	NM_030641
APOL6	hsa-miR-10527-5p	83.0197	NM_030641
APOL6	hsa-miR-625-3p	82.9077	NM_030641
APOL6	hsa-miR-519d-5p	82.8422	NM_030641
APOL6	hsa-miR-4775	82.6948	NM_030641
APOL6	hsa-miR-548bc	82.5698	NM_030641
APOL6	hsa-miR-519a-2-5p	82.2952	NM_030641
APOL6	hsa-miR-520b-5p	82.2952	NM_030641
APOL6	hsa-miR-6807-5p	81.8623	NM_030641
APOL6	hsa-miR-6785-5p	81.6983	NM_030641
APOL6	hsa-miR-1207-5p	81.3887	NM_030641
APOL6	hsa-miR-190a-3p	81.3266	NM_030641
APOL6	hsa-miR-4763-3p	80.865	NM_030641
APOL6	hsa-miR-340-5p	80.7545	NM_030641
APOL6	hsa-miR-4768-3p	80.6242	NM_030641

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Motifs and transcription factors (TFs) regulating APOL6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
APOL6	metacluster_2.6	IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF3; IRF3; IRF3; IRF3; IRF3; IRF3; IRF4; IRF4; IRF4; IRF4; IRF4; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF6; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; STAT1; STAT2; STAT2; STAT2; STAT2; ZNF426; ZNF71 (directAnnotation). IRF1; IRF1; IRF3; IRF8 (inferredBy_Orthology).
APOL6	metacluster_2.8	IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology).
APOL6	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
APOL6	tfdimers__MD00208	IRF1; LTF (directAnnotation).
APOL6	metacluster_2.9	IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology).
APOL6	metacluster_2.7	IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology).
APOL6	jaspar__MA1509.1	IRF6 (directAnnotation).
APOL6	transfac_pro__M04887	TCF12 (directAnnotation).
APOL6	tfdimers__MD00183	CRX; YY1 (directAnnotation).
APOL6	metacluster_56.4	HSF1; HSF2; HSF2; HSF4 (directAnnotation).
APOL6	tfdimers__MD00138	IRF1; IRF2; IRF3; IRF4; IRF5; IRF7; IRF8; IRF9; MYB (directAnnotation).
APOL6	metacluster_21.5	HOXB2; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4 (directAnnotation). HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4; HSF4; HSF5; HSF5; HSF5; HSF5; HSFX1; HSFX1; HSFX1; HSFX1; HSFX2; HSFX2; HSFX2; HSFX2; HSFX3; HSFX3; HSFX3; HSFX3; HSFX4; HSFX4; HSFX4; HSFX4; HSFY1; HSFY1; HSFY1; HSFY1; HSFY2; HSFY2; HSFY2; HSFY2 (inferredBy_Orthology).
APOL6	kznf__ZNF485_Imbeault2017_RP_RCADE	ZNF485 (directAnnotation).
APOL6	transfac_pro__M05379	ZNF740 (inferredBy_Orthology).
APOL6	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
APOL6	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
APOL6	swissregulon__mm__Elf3	ELF3 (inferredBy_Orthology).
APOL6	hocomoco__OTX1_HUMAN.H11MO.0.D	OTX1 (directAnnotation).
APOL6	taipale_tf_pairs__PITX1_TBX21_AGGTGNGAARGGATTA_CAP_repr	PITX1; TBX21 (directAnnotation).
APOL6	transfac_pro__M06313	ZNF678 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."