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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: APOL4

Summary for APOL4

Gene information	Gene symbol	APOL4
	Ensembl ID	ENSG00000100336
	Entrez ID	80832
	Gene name	apolipoprotein L4
	Synonyms	APOLIV
	Gene type	protein_coding
	UniProtAcc	Q9BPW4

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Dataset with differentially expressed gene: APOL4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Erythrocytes	-0.325923	4.50e-04

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Expression of APOL4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to APOL4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating APOL4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
APOL4	hsa-miR-4457	97.2876	NM_145660
APOL4	hsa-miR-934	95.0304	NM_145660
APOL4	hsa-miR-2110	92.5302	NM_145660
APOL4	hsa-miR-450a-2-3p	91.344	NM_145660
APOL4	hsa-miR-149-5p	90.2298	NM_145660
APOL4	hsa-miR-3140-3p	89.8444	NM_145660
APOL4	hsa-miR-539-5p	85.366	NM_145660
APOL4	hsa-miR-513b-5p	84.9725	NM_145660
APOL4	hsa-miR-6888-5p	81.1923	NM_145660

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Motifs and transcription factors (TFs) regulating APOL4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
APOL4	taipale_tf_pairs__ETV2_RFX5_NCCGGAAGYNNCNTAGCAACS_CAP_repr	ETV2; RFX5 (directAnnotation).
APOL4	tfdimers__MD00208	IRF1; LTF (directAnnotation).
APOL4	metacluster_38.1	ETV7; ETV7; STAT1; STAT1; STAT1; STAT1; STAT1; STAT1; STAT1; STAT1; STAT1; STAT1; STAT3; STAT3; STAT3; STAT3; STAT3; STAT3; STAT3; STAT3; STAT3; STAT4; STAT5A; STAT5B (directAnnotation). STAT1; STAT3; STAT3; STAT4; STAT5A; STAT5A; STAT5B; STAT5B; STAT6; STAT6 (inferredBy_Orthology).
APOL4	metacluster_29.2	BCL6; IRF3; IRF3; STAT1; STAT1; STAT1; STAT2; STAT3; STAT3; STAT3; STAT4; STAT4; STAT5A; STAT5A; STAT5A; STAT5A; STAT5B; STAT5B; STAT5B; STAT6 (directAnnotation). STAT3; STAT5A; STAT5A; STAT5A; STAT5A; STAT5A; STAT5B; STAT5B; STAT6; STAT6 (inferredBy_Orthology).
APOL4	metacluster_85.6	ZNF74 (directAnnotation).
APOL4	metacluster_168.14	ZNF33A; ZNF33B; ZNF394; ZNF768 (directAnnotation). ZNF768 (inferredBy_Orthology).
APOL4	transfac_pro__M01890	STAT5A (directAnnotation).
APOL4	homer__YCTTTGTTCC_Sox4	SOX4 (inferredBy_Orthology).
APOL4	metacluster_29.1	STAT4; STAT5A; STAT5A; STAT5B (directAnnotation). STAT5B; STAT5B (inferredBy_Orthology).
APOL4	tfdimers__MD00088	HMGA1; HMGA2 (directAnnotation).
APOL4	taipale_tf_pairs__ERF_MAX_RSCGGAANCACGTGN_CAP_repr	ERF; MAX (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."