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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: APH1A

Summary for APH1A

Gene information	Gene symbol	APH1A
	Ensembl ID	ENSG00000117362
	Entrez ID	51107
	Gene name	aph-1 homolog A, gamma-secretase subunit
	Synonyms	APH-1A\|CGI-78
	Gene type	protein_coding
	UniProtAcc	Q96BI3

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Dataset with differentially expressed gene: APH1A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.40154	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.630949	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.682478	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.260108	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.273688	1.42e-15
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.260141	4.09e-07
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.344771	1.22e-19
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.668496	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.262186	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.324188	0.00e+00

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Expression of APH1A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to APH1A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating APH1A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
APH1A	hsa-miR-198	96.9454	NM_001077628
APH1A	hsa-miR-92a-2-5p	96.0139	NM_001243771
APH1A	hsa-miR-922	95.1453	NM_001077628
APH1A	hsa-miR-4251	93.3966	NM_001243771
APH1A	hsa-miR-2682-5p	93.1843	NM_001243771
APH1A	hsa-miR-34b-5p	93.1843	NM_001243771
APH1A	hsa-miR-449c-5p	93.1843	NM_001243771
APH1A	hsa-miR-548x-3p	91.9417	NM_001243771
APH1A	hsa-miR-548aj-3p	91.9417	NM_001243771
APH1A	hsa-miR-3714	91.6214	NM_001243771
APH1A	hsa-miR-6891-5p	91.5723	NM_001077628
APH1A	hsa-miR-548am-3p	91.5014	NM_001243771
APH1A	hsa-miR-548ae-3p	91.5014	NM_001243771
APH1A	hsa-miR-548ah-3p	91.5014	NM_001243771
APH1A	hsa-miR-548aq-3p	91.5014	NM_001243771
APH1A	hsa-miR-548j-3p	91.5014	NM_001243771
APH1A	hsa-miR-3173-3p	89.5857	NM_001077628
APH1A	hsa-miR-6837-5p	89.555	NM_001077628
APH1A	hsa-miR-4685-5p	89.555	NM_001077628
APH1A	hsa-miR-3667-3p	88.5362	NM_001077628
APH1A	hsa-miR-12118	88.4228	NM_001077628
APH1A	hsa-miR-539-5p	88.3037	NM_001243771
APH1A	hsa-miR-3679-3p	88.1645	NM_001077628
APH1A	hsa-miR-4324	86.0288	NM_001243771
APH1A	hsa-miR-6832-3p	85.9928	NM_001077628
APH1A	hsa-miR-6734-3p	85.8441	NM_001077628
APH1A	hsa-miR-6823-3p	85.841	NM_001077628
APH1A	hsa-miR-8063	84.964	NM_001243771
APH1A	hsa-miR-151b	84.678	NM_001077628
APH1A	hsa-miR-151a-5p	84.678	NM_001077628
APH1A	hsa-miR-491-5p	84.6046	NM_001243771
APH1A	hsa-miR-4306	84.2425	NM_001077628
APH1A	hsa-miR-4531	83.7638	NM_001077628
APH1A	hsa-miR-6721-5p	83.123	NM_001243771
APH1A	hsa-miR-2114-3p	83.1074	NM_001077628
APH1A	hsa-miR-548an	81.5612	NM_001243771
APH1A	hsa-miR-6857-5p	81.2181	NM_001243771
APH1A	hsa-miR-548h-3p	80.6281	NM_001243771
APH1A	hsa-miR-548ac	80.6281	NM_001243771
APH1A	hsa-miR-548z	80.6281	NM_001243771
APH1A	hsa-miR-548d-3p	80.6281	NM_001243771
APH1A	hsa-miR-548bb-3p	80.6281	NM_001243771
APH1A	hsa-miR-6865-3p	80.5402	NM_001243771

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Motifs and transcription factors (TFs) regulating APH1A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
APH1A	hdpi__ETV4	ETV4 (directAnnotation).
APH1A	transfac_pro__M04826	EP300 (directAnnotation).
APH1A	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
APH1A	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
APH1A	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
APH1A	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
APH1A	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
APH1A	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
APH1A	hdpi__FLI1	FLI1 (directAnnotation).
APH1A	transfac_pro__M05605	GATA6 (inferredBy_Orthology).
APH1A	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
APH1A	jaspar__MA1933.1	SREBF2 (directAnnotation).
APH1A	cisbp__M02645	ETS1 (directAnnotation).
APH1A	dbtfbs__ZNF121_HEK293_ENCSR224QDY_merged_N3	ZNF121 (directAnnotation).
APH1A	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
APH1A	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
APH1A	transfac_pro__M00492	STAT1 (directAnnotation).
APH1A	swissregulon__hs__ELK1	ELK1 (directAnnotation).
APH1A	metacluster_183.4	ETS1 (inferredBy_Orthology).
APH1A	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
APH1A	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
APH1A	transfac_pro__M04748	GABPA (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
APH1A	"E-2012"	DB05171	small molecule
APH1A	"MK-0752"	DB12852	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."