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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: APEX1

Summary for APEX1

Gene information	Gene symbol	APEX1
	Ensembl ID	ENSG00000100823
	Entrez ID	328
	Gene name	apurinic/apyrimidinic endodeoxyribonuclease 1
	Synonyms	APE\|APE-1\|APEN\|APEX\|APX\|HAP1\|REF-1\|REF1
	Gene type	protein_coding
	UniProtAcc	P27695

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Dataset with differentially expressed gene: APEX1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.256996	2.21e-10
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Progenitors	0.653985	5.60e-04
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.357787	2.88e-07
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.521723	1.54e-43
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.285424	4.85e-35
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.888001	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.838245	3.05e-03
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.310265	8.83e-16
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.493282	3.01e-33
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.317915	1.46e-10

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Expression of APEX1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to APEX1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating APEX1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
APEX1	hsa-miR-6774-5p	92.1505	NM_080649
APEX1	hsa-miR-635	92.1505	NM_080649
APEX1	hsa-miR-520g-3p	89.6194	NM_080649
APEX1	hsa-miR-520h	89.6194	NM_080649
APEX1	hsa-miR-27a-5p	88.5631	NM_080649
APEX1	hsa-miR-539-5p	86.8564	NM_080649
APEX1	hsa-miR-7975	86.7146	NM_080649
APEX1	hsa-miR-376b-5p	85.5328	NM_080649
APEX1	hsa-miR-376c-5p	85.5328	NM_080649

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Motifs and transcription factors (TFs) regulating APEX1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
APEX1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
APEX1	transfac_public__M00024	E2F1 (directAnnotation).
APEX1	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
APEX1	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
APEX1	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
APEX1	homer__NCCACGTG_c-Myc	MYC (directAnnotation).
APEX1	transfac_pro__M06032	ZNF727 (directAnnotation).
APEX1	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
APEX1	metacluster_57.3	ARNT; ATF3; ATF3; ATF3; ATF3; BHLHE40; BHLHE40; BHLHE40; BHLHE41; BHLHE41; BHLHE41; MITF; MITF; MITF; MLX; MLXIPL; SREBF1; SREBF1; SREBF1; SREBF1; SREBF2; SREBF2; SREBF2; TFE3; TFEC; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; ZNF507 (directAnnotation). ARNTL; BHLHE40; BHLHE40; BHLHE41; HELT; HES1; HES2; HES3; HES5; HES6; HES7; HEY1; HEY2; HEYL; MLX; MLX; SREBF1; SREBF2; TFE3; USF1; USF1; USF2; USF2 (inferredBy_Orthology).
APEX1	metacluster_14.20	TFEB (directAnnotation).
APEX1	metacluster_14.12	ARNT; MAX; USF1 (directAnnotation).
APEX1	metacluster_14.13	MAX; USF1; USF1 (directAnnotation).
APEX1	metacluster_14.23	TFE3 (directAnnotation).
APEX1	cisbp__M07803	MYC (directAnnotation).
APEX1	metacluster_14.10	MLX; TFE3; TFEB; USF1; USF2 (directAnnotation). USF1 (inferredBy_Orthology).
APEX1	metacluster_57.2	BACH1; MITF; MITF; TFE3; TFE3; TFE3; TFEB; USF2 (directAnnotation). MITF; TFE3; USF1; USF2 (inferredBy_Orthology).
APEX1	transfac_pro__M07384	HIF1A (directAnnotation).
APEX1	metacluster_10.46	MAX (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
APEX1	"Lucanthone"	DB04967	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."