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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: AP2B1

Summary for AP2B1

Gene information	Gene symbol	AP2B1
	Ensembl ID	ENSG00000006125
	Entrez ID	163
	Gene name	adaptor related protein complex 2 subunit beta 1
	Synonyms	ADTB2\|CLAPB1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: AP2B1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.591187	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.28329	2.28e-33
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.325755	6.67e-11
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.551479	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.337947	0.00e+00

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Expression of AP2B1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AP2B1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AP2B1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AP2B1	hsa-miR-5195-3p	94.9753	NM_001030006
AP2B1	hsa-miR-145-5p	94.9753	NM_001030006
AP2B1	hsa-miR-6875-3p	94.8157	NM_001030006
AP2B1	hsa-miR-6499-3p	94.1846	NM_001282
AP2B1	hsa-miR-502-5p	93.3139	NM_001030006
AP2B1	hsa-miR-5010-3p	92.7094	NM_001282
AP2B1	hsa-miR-106b-5p	91.7	NM_001282
AP2B1	hsa-miR-20a-5p	91.7	NM_001282
AP2B1	hsa-miR-711	90.2952	NM_001030006
AP2B1	hsa-miR-20b-5p	89.7358	NM_001282
AP2B1	hsa-miR-519d-3p	89.7358	NM_001282
AP2B1	hsa-miR-106a-5p	89.7358	NM_001282
AP2B1	hsa-miR-93-5p	89.7358	NM_001282
AP2B1	hsa-miR-17-5p	89.7358	NM_001282
AP2B1	hsa-miR-524-5p	89.5773	NM_001030006
AP2B1	hsa-miR-520d-5p	89.5773	NM_001030006
AP2B1	hsa-miR-526b-3p	89.1757	NM_001282
AP2B1	hsa-miR-3140-3p	88.0643	NM_001282
AP2B1	hsa-miR-5583-3p	87.4821	NM_001282
AP2B1	hsa-miR-3157-3p	86.0255	NM_001030006
AP2B1	hsa-miR-1276	80.974	NM_001282
AP2B1	hsa-miR-8076	80.3791	NM_001282

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Motifs and transcription factors (TFs) regulating AP2B1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AP2B1	metacluster_7.13	ZFX (directAnnotation).
AP2B1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
AP2B1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
AP2B1	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
AP2B1	jaspar__MA1483.2	ELF2 (directAnnotation).
AP2B1	metacluster_151.2	ZNF23 (directAnnotation).
AP2B1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
AP2B1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
AP2B1	metacluster_182.10	ZFX (directAnnotation).
AP2B1	hdpi__ETV4	ETV4 (directAnnotation).
AP2B1	jaspar__MA0748.2	YY2 (directAnnotation).
AP2B1	transfac_pro__M06213	ZNF267 (directAnnotation).
AP2B1	transfac_pro__M01861	ATF1 (directAnnotation).
AP2B1	kznf__PRDM1_modENCODE.2_ChIP-seq	PRDM1 (directAnnotation).
AP2B1	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
AP2B1	swissregulon__hs__KLF6	KLF6 (directAnnotation).
AP2B1	transfac_pro__M06520	ZNF721 (directAnnotation).
AP2B1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
AP2B1	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
AP2B1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
AP2B1	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
AP2B1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
AP2B1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
AP2B1	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
AP2B1	cisbp__M02645	ETS1 (directAnnotation).
AP2B1	swissregulon__hs__ETV6	ETV6 (directAnnotation).
AP2B1	cisbp__M08198	ELF1 (directAnnotation).
AP2B1	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
AP2B1	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
AP2B1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
AP2B1	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
AP2B1	hdpi__TP73	TP73 (directAnnotation).
AP2B1	hdpi__ELF2	ELF2 (directAnnotation).
AP2B1	metacluster_183.4	ETS1 (inferredBy_Orthology).
AP2B1	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
AP2B1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
AP2B1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
AP2B1	metacluster_81.7	CREB1 (directAnnotation).
AP2B1	taipale_tf_pairs__ETV5_HOXB13_NNCGGANGNNNTWAA_CAP	ETV5; HOXB13 (directAnnotation).
AP2B1	metacluster_35.5	ELF1; ELF2; ELF3; ELF3; ELK1; ELK4; ERF; ERG; ETS1; ETS1; ETS2; ETV7; ETV7; FLI1; FLI1 (directAnnotation).
AP2B1	hdpi__FLI1	FLI1 (directAnnotation).
AP2B1	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
AP2B1	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."