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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ANXA7

Summary for ANXA7

Gene information	Gene symbol	ANXA7
	Ensembl ID	ENSG00000138279
	Entrez ID	310
	Gene name	annexin A7
	Synonyms	ANX7
	Gene type	protein_coding
	UniProtAcc	P20073

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Dataset with differentially expressed gene: ANXA7

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.268475	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.299422	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.288159	6.50e-40
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.350376	2.46e-17
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.325251	2.47e-08
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.505405	1.26e-32
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.415916	7.60e-16
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	-0.258112	0.00e+00

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Expression of ANXA7 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ANXA7

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ANXA7

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ANXA7	hsa-miR-3925-5p	93.1922	NM_001156
ANXA7	hsa-miR-548ad-3p	91.4645	NM_001156
ANXA7	hsa-miR-6805-3p	91.2038	NM_001156
ANXA7	hsa-miR-5691	91.2038	NM_001156
ANXA7	hsa-miR-4672	91.2019	NM_001156
ANXA7	hsa-miR-297	90.6183	NM_001156
ANXA7	hsa-miR-124-3p	90.5915	NM_001156
ANXA7	hsa-miR-506-3p	90.5915	NM_001156
ANXA7	hsa-miR-3714	90.1388	NM_001156
ANXA7	hsa-miR-6832-5p	89.5885	NM_001156
ANXA7	hsa-miR-197-3p	87.9952	NM_001156
ANXA7	hsa-miR-3910	87.6231	NM_001156
ANXA7	hsa-miR-4732-5p	86.6208	NM_001156
ANXA7	hsa-miR-195-3p	85.7011	NM_001156
ANXA7	hsa-miR-16-2-3p	85.7011	NM_001156
ANXA7	hsa-miR-4639-5p	85.2864	NM_001156
ANXA7	hsa-miR-4761-5p	85.1546	NM_001156
ANXA7	hsa-miR-135b-5p	84.6839	NM_001156
ANXA7	hsa-miR-135a-5p	84.6839	NM_001156
ANXA7	hsa-miR-6833-5p	84.1719	NM_001156
ANXA7	hsa-miR-4289	83.4399	NM_001156
ANXA7	hsa-miR-12127	81.948	NM_001156
ANXA7	hsa-miR-335-3p	81.8329	NM_001156
ANXA7	hsa-miR-4657	81.6863	NM_001156
ANXA7	hsa-miR-4491	81.6863	NM_001156
ANXA7	hsa-miR-7161-3p	81.2788	NM_001156

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Motifs and transcription factors (TFs) regulating ANXA7

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ANXA7	transfac_pro__M05670	ZNF37A (directAnnotation).
ANXA7	taipale_tf_pairs__ERF_HOXA3_RSCGGAWNNNNNNNYMATTA_CAP_repr	ERF; HOXA3 (directAnnotation).
ANXA7	cisbp__M02645	ETS1 (directAnnotation).
ANXA7	metacluster_161.2	LHX8 (directAnnotation).
ANXA7	metacluster_161.4	LHX9 (directAnnotation).
ANXA7	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
ANXA7	metacluster_161.31	PRRX2 (directAnnotation).
ANXA7	hdpi__ETV4	ETV4 (directAnnotation).
ANXA7	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
ANXA7	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
ANXA7	hdpi__ELF2	ELF2 (directAnnotation).
ANXA7	swissregulon__hs__ELK1	ELK1 (directAnnotation).
ANXA7	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ANXA7	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
ANXA7	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ANXA7	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
ANXA7	transfac_pro__M00492	STAT1 (directAnnotation).
ANXA7	cisbp__M00808	MYPOP (inferredBy_Orthology).
ANXA7	dbtfbs__E4F1_K562_ENCSR731LHZ_merged_N1	E4F1 (directAnnotation).
ANXA7	transfac_pro__M04950	EGR1 (directAnnotation).
ANXA7	metacluster_7.7	SP2 (directAnnotation). KLF16 (inferredBy_Orthology).
ANXA7	metacluster_172.6	CHD2; E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."