Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ANXA4

Summary for ANXA4

Gene information	Gene symbol	ANXA4
	Ensembl ID	ENSG00000196975
	Entrez ID	307
	Gene name	annexin A4
	Synonyms	ANX4
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: ANXA4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.04406	2.96e-06
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.276609	1.26e-08
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	B cells	-0.618891	3.08e-06
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.343762	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.330262	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.74671	0.00e+00

Top

Expression of ANXA4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to ANXA4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating ANXA4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ANXA4	hsa-miR-6083	97.1964	NM_001153
ANXA4	hsa-miR-3065-5p	95.0996	NM_001153
ANXA4	hsa-miR-4670-3p	93.2218	NM_001153
ANXA4	hsa-miR-4519	90.9969	NM_001153
ANXA4	hsa-miR-5000-5p	90.5436	NM_001153
ANXA4	hsa-miR-8076	88.7818	NM_001153
ANXA4	hsa-miR-5583-3p	88.7354	NM_001153
ANXA4	hsa-miR-181b-3p	88.6271	NM_001153
ANXA4	hsa-miR-181b-2-3p	88.6271	NM_001153
ANXA4	hsa-miR-4420	88.6271	NM_001153
ANXA4	hsa-miR-5584-5p	88.2346	NM_001153
ANXA4	hsa-miR-10525-3p	87.3889	NM_001153
ANXA4	hsa-miR-585-5p	87.0637	NM_001153
ANXA4	hsa-miR-12136	86.8638	NM_001153
ANXA4	hsa-miR-520h	86.3199	NM_001153
ANXA4	hsa-miR-520g-3p	86.3199	NM_001153
ANXA4	hsa-miR-4422	84.0174	NM_001153
ANXA4	hsa-miR-148a-3p	83.4876	NM_001153
ANXA4	hsa-miR-148b-3p	83.4876	NM_001153
ANXA4	hsa-miR-152-3p	83.4876	NM_001153
ANXA4	hsa-miR-6800-5p	83.1122	NM_001153
ANXA4	hsa-miR-154-3p	80.6122	NM_001153
ANXA4	hsa-miR-487a-3p	80.6122	NM_001153
ANXA4	hsa-miR-1-3p	80.3103	NM_001153
ANXA4	hsa-miR-206	80.3103	NM_001153

Page: 1

Top

Motifs and transcription factors (TFs) regulating ANXA4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ANXA4	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
ANXA4	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
ANXA4	transfac_pro__M04617	ZBTB7A (directAnnotation).
ANXA4	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
ANXA4	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ANXA4	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ANXA4	transfac_pro__M07387	ZBTB7A (directAnnotation).
ANXA4	transfac_pro__M07436	WT1 (directAnnotation).
ANXA4	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ANXA4	transfac_pro__M00716	ZBTB14 (directAnnotation).
ANXA4	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ANXA4	hdpi__HIP2	UBE2K (directAnnotation).
ANXA4	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ANXA4	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ANXA4	transfac_pro__M04893	TAF1 (directAnnotation).
ANXA4	transfac_pro__M03876	ZBTB33 (directAnnotation).
ANXA4	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ANXA4	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ANXA4	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
ANXA4	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ANXA4	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ANXA4	jaspar__MA1125.1	ZNF384 (directAnnotation).
ANXA4	metacluster_144.10	ZNF100 (directAnnotation).
ANXA4	metacluster_0.5	ZNF264 (directAnnotation).
ANXA4	metacluster_46.5	HLF; TEF (directAnnotation).
ANXA4	transfac_pro__M01297	HOXA13 (directAnnotation).
ANXA4	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
ANXA4	metacluster_9.49	POU3F4 (inferredBy_Orthology).
ANXA4	metacluster_47.1	E4F1; SPDEF; SPDEF (directAnnotation).
ANXA4	transfac_pro__M06995	NFE2L3 (directAnnotation).
ANXA4	cisbp__M01815	CEBPE (inferredBy_Orthology).
ANXA4	transfac_pro__M06521	ZFP62 (directAnnotation).
ANXA4	tfdimers__MD00472	EP300; HOXA13 (directAnnotation).
ANXA4	metacluster_178.10	POU2F2; POU4F1; POU4F1; POU4F2; POU4F2; POU4F3; POU4F3 (directAnnotation). CCDC160; HDX; POU1F1; POU2F1; POU2F2; POU3F1; POU3F2; POU3F3; POU3F4; POU4F1; POU4F2; POU4F3; POU5F1; POU5F1B; POU5F2; POU6F1; POU6F2 (inferredBy_Orthology).
ANXA4	metacluster_130.3	ZNF492; ZNF492 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
ANXA4	swissregulon__mm__Pbx1	PBX1 (inferredBy_Orthology).
ANXA4	kznf__ZKSCAN2_Imbeault2017_OM_RCADE	ZKSCAN2 (directAnnotation).
ANXA4	metacluster_135.11	NR2C2 (directAnnotation).
ANXA4	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ANXA4	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ANXA4	metacluster_7.13	ZFX (directAnnotation).
ANXA4	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ANXA4	cisbp__M00968	MTF2 (directAnnotation).
ANXA4	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ANXA4	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ANXA4	cisbp__M00341	PAX6 (directAnnotation).
ANXA4	metacluster_198.3	ZFP64 (directAnnotation).
ANXA4	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ANXA4	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ANXA4	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).

Page: 1 2 3

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ANXA4	"Copper"	DB09130	small molecule
ANXA4	"Fluocinolone acetonide"	DB00591	small molecule

Page: 1

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."