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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ANTXR2

Summary for ANTXR2

Gene information	Gene symbol	ANTXR2
	Ensembl ID	ENSG00000163297
	Entrez ID	118429
	Gene name	ANTXR cell adhesion molecule 2
	Synonyms	CMG-2\|CMG2\|FLJ31074
	Gene type	protein_coding
	UniProtAcc	P58335

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Dataset with differentially expressed gene: ANTXR2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.28357	5.96e-03
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.431714	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.261655	1.43e-10
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.479943	0.00e+00

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Expression of ANTXR2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ANTXR2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ANTXR2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ANTXR2	hsa-miR-3910	99.2306	NM_001286781
ANTXR2	hsa-miR-506-3p	98.3774	NM_001286781
ANTXR2	hsa-miR-124-3p	97.8929	NM_001286781
ANTXR2	hsa-miR-3714	97.6917	NM_001286781
ANTXR2	hsa-miR-3145-3p	97.5299	NM_001286781
ANTXR2	hsa-miR-5011-5p	97.3778	NM_001286781
ANTXR2	hsa-miR-4775	97.0797	NM_001286781
ANTXR2	hsa-miR-6719-3p	97.0283	NM_001286781
ANTXR2	hsa-miR-335-3p	96.592	NM_001286781
ANTXR2	hsa-miR-6867-5p	95.8794	NM_001286781
ANTXR2	hsa-miR-4803	95.2712	NM_001286781
ANTXR2	hsa-miR-4307	94.0986	NM_001286781
ANTXR2	hsa-miR-5680	94.0584	NM_001286781
ANTXR2	hsa-miR-190a-3p	94.0304	NM_001286781
ANTXR2	hsa-miR-5585-5p	92.9778	NM_001286781
ANTXR2	hsa-miR-4795-3p	92.8445	NM_001286781
ANTXR2	hsa-miR-6873-3p	91.8974	NM_001286781
ANTXR2	hsa-miR-1279	91.7806	NM_001286781
ANTXR2	hsa-miR-1246	91.4305	NM_001286781
ANTXR2	hsa-miR-3618	91.2384	NM_001286781
ANTXR2	hsa-miR-3163	89.9084	NM_001286781
ANTXR2	hsa-miR-203a-3p	89.6727	NM_001286781
ANTXR2	hsa-miR-587	89.0103	NM_001286781
ANTXR2	hsa-miR-5582-5p	88.8522	NM_001286781
ANTXR2	hsa-miR-548an	88.3145	NM_001286781
ANTXR2	hsa-miR-30d-3p	87.9055	NM_001286781
ANTXR2	hsa-miR-30a-3p	87.9055	NM_001286781
ANTXR2	hsa-miR-30e-3p	87.9055	NM_001286781
ANTXR2	hsa-miR-513a-5p	87.5054	NM_001286781
ANTXR2	hsa-miR-3059-5p	87.3701	NM_001286781
ANTXR2	hsa-miR-664b-3p	87.2353	NM_001286781
ANTXR2	hsa-miR-579-3p	87.2353	NM_001286781
ANTXR2	hsa-miR-577	87.1041	NM_001286781
ANTXR2	hsa-miR-126-5p	87.0299	NM_001286781
ANTXR2	hsa-miR-513a-3p	86.9856	NM_001286781
ANTXR2	hsa-miR-513c-3p	86.9856	NM_001286781
ANTXR2	hsa-miR-155-5p	86.8826	NM_001286781
ANTXR2	hsa-miR-4533	86.5528	NM_001286781
ANTXR2	hsa-miR-4707-3p	86.546	NM_001286781
ANTXR2	hsa-miR-548e-5p	86.5161	NM_001286781
ANTXR2	hsa-miR-4698	86.3867	NM_001286781
ANTXR2	hsa-miR-7-1-3p	86.273	NM_001286781
ANTXR2	hsa-miR-4482-3p	86.2108	NM_001286781
ANTXR2	hsa-miR-8063	86.0245	NM_001286781
ANTXR2	hsa-miR-6881-3p	85.6288	NM_001286781
ANTXR2	hsa-miR-1277-5p	85.3855	NM_001286781
ANTXR2	hsa-miR-7-2-3p	85.2331	NM_001286781
ANTXR2	hsa-miR-3606-3p	85.1303	NM_001286781
ANTXR2	hsa-miR-29a-3p	84.8582	NM_001286781
ANTXR2	hsa-miR-29c-3p	84.8582	NM_001286781

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Motifs and transcription factors (TFs) regulating ANTXR2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ANTXR2	kznf__PRDM1_modENCODE.2_ChIP-seq	PRDM1 (directAnnotation).
ANTXR2	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
ANTXR2	metacluster_98.1	ZNF524 (directAnnotation).
ANTXR2	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
ANTXR2	transfac_pro__M04617	ZBTB7A (directAnnotation).
ANTXR2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ANTXR2	transfac_pro__M07387	ZBTB7A (directAnnotation).
ANTXR2	transfac_pro__M07436	WT1 (directAnnotation).
ANTXR2	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ANTXR2	hdpi__HIP2	UBE2K (directAnnotation).
ANTXR2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ANTXR2	transfac_pro__M04893	TAF1 (directAnnotation).
ANTXR2	transfac_pro__M03876	ZBTB33 (directAnnotation).
ANTXR2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ANTXR2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ANTXR2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ANTXR2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ANTXR2	metacluster_135.11	NR2C2 (directAnnotation).
ANTXR2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ANTXR2	cisbp__M00968	MTF2 (directAnnotation).
ANTXR2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ANTXR2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ANTXR2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ANTXR2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ANTXR2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ANTXR2	transfac_pro__M01199	TRIM28 (directAnnotation).
ANTXR2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ANTXR2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ANTXR2	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
ANTXR2	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
ANTXR2	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
ANTXR2	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
ANTXR2	cisbp__M02645	ETS1 (directAnnotation).
ANTXR2	cisbp__M08198	ELF1 (directAnnotation).
ANTXR2	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
ANTXR2	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
ANTXR2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ANTXR2	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
ANTXR2	metacluster_81.7	CREB1 (directAnnotation).
ANTXR2	transfac_pro__M01298	MECP2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ANTXR2	"MDX-1303"	DB05945	biotech

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."