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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ANTXR1

Summary for ANTXR1

Gene information	Gene symbol	ANTXR1
	Ensembl ID	ENSG00000169604
	Entrez ID	84168
	Gene name	ANTXR cell adhesion molecule 1
	Synonyms	ATR\|FLJ10601\|FLJ21776\|TEM8
	Gene type	protein_coding
	UniProtAcc	Q9H6X2

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Dataset with differentially expressed gene: ANTXR1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.272837	9.89e-16

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Expression of ANTXR1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ANTXR1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ANTXR1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ANTXR1	hsa-miR-3658	99.831	NM_032208
ANTXR1	hsa-miR-4795-3p	98.7636	NM_032208
ANTXR1	hsa-miR-4310	98.4034	NM_032208
ANTXR1	hsa-miR-7157-5p	97.7202	NM_032208
ANTXR1	hsa-miR-493-5p	97.2686	NM_032208
ANTXR1	hsa-miR-616-3p	96.8199	NM_032208
ANTXR1	hsa-miR-4263	96.1507	NM_032208
ANTXR1	hsa-let-7a-2-3p	95.3462	NM_032208
ANTXR1	hsa-let-7g-3p	95.3462	NM_032208
ANTXR1	hsa-miR-5688	94.6531	NM_032208
ANTXR1	hsa-let-7c-3p	93.5167	NM_032208
ANTXR1	hsa-miR-495-3p	92.499	NM_032208
ANTXR1	hsa-miR-5681b	91.6158	NM_032208
ANTXR1	hsa-miR-27a-5p	91.1098	NM_032208
ANTXR1	hsa-miR-4529-3p	90.8306	NM_032208
ANTXR1	hsa-miR-6501-3p	90.7788	NM_053034
ANTXR1	hsa-miR-520g-5p	90.6214	NM_032208
ANTXR1	hsa-miR-6864-3p	90.516	NM_053034
ANTXR1	hsa-miR-3672	90.516	NM_053034
ANTXR1	hsa-miR-548e-5p	90.2996	NM_032208
ANTXR1	hsa-miR-7854-3p	90.1652	NM_032208
ANTXR1	hsa-miR-26b-3p	89.4347	NM_032208
ANTXR1	hsa-miR-4772-5p	89.079	NM_032208
ANTXR1	hsa-miR-9902	88.6531	NM_032208
ANTXR1	hsa-miR-6770-5p	88.0316	NM_032208
ANTXR1	hsa-miR-1290	86.9671	NM_032208
ANTXR1	hsa-miR-4656	86.7994	NM_032208
ANTXR1	hsa-miR-7113-5p	86.6074	NM_032208
ANTXR1	hsa-miR-6739-5p	86.4931	NM_018153
ANTXR1	hsa-miR-6733-5p	86.4931	NM_018153
ANTXR1	hsa-miR-545-5p	86.1645	NM_018153
ANTXR1	hsa-miR-126-5p	86.0604	NM_032208
ANTXR1	hsa-miR-3134	85.6057	NM_032208
ANTXR1	hsa-miR-8059	85.1721	NM_053034
ANTXR1	hsa-miR-4471	85.1721	NM_053034
ANTXR1	hsa-miR-4775	85.0777	NM_032208
ANTXR1	hsa-miR-548c-3p	84.6842	NM_032208
ANTXR1	hsa-miR-5009-5p	84.5381	NM_032208
ANTXR1	hsa-miR-12127	84.3451	NM_032208
ANTXR1	hsa-miR-3128	84.302	NM_032208
ANTXR1	hsa-miR-548an	83.9975	NM_032208
ANTXR1	hsa-miR-5189-3p	83.6269	NM_032208
ANTXR1	hsa-miR-4659b-5p	83.5116	NM_032208
ANTXR1	hsa-miR-4659b-3p	83.4516	NM_018153
ANTXR1	hsa-miR-4659a-3p	83.4516	NM_018153
ANTXR1	hsa-miR-3200-5p	83.0199	NM_032208
ANTXR1	hsa-miR-4437	82.5995	NM_032208
ANTXR1	hsa-miR-302c-5p	82.5369	NM_018153
ANTXR1	hsa-miR-2115-5p	82.3666	NM_032208
ANTXR1	hsa-miR-6818-5p	82.3372	NM_032208

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Motifs and transcription factors (TFs) regulating ANTXR1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ANTXR1	"MDX-1303"	DB05945	biotech

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."