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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ANO6

Summary for ANO6

Gene information	Gene symbol	ANO6
	Ensembl ID	ENSG00000177119
	Entrez ID	196527
	Gene name	anoctamin 6
	Synonyms	DKFZp313M0720\|TMEM16F
	Gene type	protein_coding
	UniProtAcc	Q4KMQ2

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Dataset with differentially expressed gene: ANO6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.275682	4.24e-18

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Expression of ANO6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ANO6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ANO6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ANO6	hsa-miR-3662	99.0696	NM_001025356
ANO6	hsa-miR-186-5p	98.1479	NM_001025356
ANO6	hsa-miR-3143	97.1366	NM_001025356
ANO6	hsa-miR-3646	95.2149	NM_001025356
ANO6	hsa-miR-4738-3p	93.3884	NM_001025356
ANO6	hsa-miR-106b-5p	93.209	NM_001025356
ANO6	hsa-miR-20a-5p	93.209	NM_001025356
ANO6	hsa-miR-6859-3p	92.4485	NM_001025356
ANO6	hsa-miR-361-5p	92.0773	NM_001025356
ANO6	hsa-miR-138-1-3p	92.0693	NM_001025356
ANO6	hsa-miR-526b-3p	91.8208	NM_001025356
ANO6	hsa-miR-17-5p	91.8208	NM_001025356
ANO6	hsa-miR-106a-5p	91.8208	NM_001025356
ANO6	hsa-miR-93-5p	91.8208	NM_001025356
ANO6	hsa-miR-519d-3p	91.8208	NM_001025356
ANO6	hsa-miR-20b-5p	91.8208	NM_001025356
ANO6	hsa-miR-616-5p	91.4778	NM_001142679
ANO6	hsa-miR-371b-5p	91.4778	NM_001142679
ANO6	hsa-miR-373-5p	91.4778	NM_001142679
ANO6	hsa-miR-3613-3p	91.1428	NM_001142679
ANO6	hsa-miR-3916	89.5928	NM_001142679
ANO6	hsa-miR-877-5p	89.2725	NM_001142679
ANO6	hsa-miR-4660	88.8465	NM_001142679
ANO6	hsa-miR-6507-5p	88.4128	NM_001025356
ANO6	hsa-miR-6505-5p	88.3859	NM_001142679
ANO6	hsa-miR-3125	88.2448	NM_001142679
ANO6	hsa-miR-8062	87.2682	NM_001025356
ANO6	hsa-miR-548c-3p	87.2619	NM_001025356
ANO6	hsa-miR-496	86.6887	NM_001025356
ANO6	hsa-miR-2115-3p	86.4923	NM_001025356
ANO6	hsa-miR-4517	86.4629	NM_001025356
ANO6	hsa-miR-3609	86.1579	NM_001025356
ANO6	hsa-miR-6859-5p	86.0733	NM_001142679
ANO6	hsa-miR-548ah-5p	86.0217	NM_001025356
ANO6	hsa-miR-302e	85.9401	NM_001025356
ANO6	hsa-miR-4756-5p	85.8196	NM_001142679
ANO6	hsa-miR-4739	85.8196	NM_001142679
ANO6	hsa-miR-1321	85.8196	NM_001142679
ANO6	hsa-miR-3161	85.1539	NM_001025356
ANO6	hsa-miR-6733-3p	85.1456	NM_001025356
ANO6	hsa-miR-7106-5p	84.7997	NM_001142679
ANO6	hsa-miR-371a-5p	84.7024	NM_001025356
ANO6	hsa-miR-6886-3p	84.6679	NM_001025356
ANO6	hsa-miR-5006-3p	84.3929	NM_001025356
ANO6	hsa-miR-4755-5p	84.3929	NM_001025356
ANO6	hsa-miR-7114-5p	84.3479	NM_001025356
ANO6	hsa-miR-4796-3p	84.3351	NM_001025356
ANO6	hsa-miR-6847-3p	84.2623	NM_001025356
ANO6	hsa-miR-549a-5p	84.2623	NM_001025356
ANO6	hsa-miR-140-5p	84.2158	NM_001025356

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Motifs and transcription factors (TFs) regulating ANO6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ANO6	metacluster_135.11	NR2C2 (directAnnotation).
ANO6	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ANO6	tfdimers__MD00038	TFAP2C (directAnnotation).
ANO6	metacluster_7.13	ZFX (directAnnotation).
ANO6	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ANO6	cisbp__M00968	MTF2 (directAnnotation).
ANO6	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ANO6	cisbp__M00341	PAX6 (directAnnotation).
ANO6	metacluster_198.3	ZFP64 (directAnnotation).
ANO6	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ANO6	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ANO6	cisbp__M00788	ZFY (inferredBy_Orthology).
ANO6	metacluster_175.1	ZNF283 (directAnnotation).
ANO6	hdpi__ZNF304	ZNF304 (directAnnotation).
ANO6	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ANO6	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ANO6	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ANO6	transfac_pro__M01199	TRIM28 (directAnnotation).
ANO6	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ANO6	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ANO6	transfac_pro__M03806	ZBTB7C (directAnnotation).
ANO6	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."