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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ANLN

Summary for ANLN

Gene information	Gene symbol	ANLN
	Ensembl ID	ENSG00000011426
	Entrez ID	54443
	Gene name	anillin, actin binding protein
	Synonyms	ANILLIN\|scra\|Scraps
	Gene type	protein_coding
	UniProtAcc	Q9NQW6

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Dataset with differentially expressed gene: ANLN

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.805516	0.00e+00

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Expression of ANLN in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ANLN

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ANLN

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ANLN	hsa-miR-217-5p	99.2819	NM_001284301
ANLN	hsa-miR-6807-3p	98.934	NM_001284301
ANLN	hsa-miR-122b-5p	96.8651	NM_001284301
ANLN	hsa-miR-3163	95.91	NM_001284302
ANLN	hsa-miR-646	93.9184	NM_001284301
ANLN	hsa-miR-3119	93.5992	NM_001284302
ANLN	hsa-miR-495-3p	93.3086	NM_001284302
ANLN	hsa-miR-5688	93.3086	NM_001284302
ANLN	hsa-miR-4255	92.9909	NM_001284301
ANLN	hsa-miR-4422	92.0259	NM_001284301
ANLN	hsa-miR-520g-3p	91.866	NM_001284302
ANLN	hsa-miR-520h	91.866	NM_001284302
ANLN	hsa-miR-6082	91.6474	NM_001284302
ANLN	hsa-miR-509-3-5p	91.0204	NM_001284301
ANLN	hsa-miR-509-5p	91.0204	NM_001284301
ANLN	hsa-miR-3133	90.4501	NM_001284302
ANLN	hsa-miR-1252-3p	90.088	NM_001284302
ANLN	hsa-miR-3188	89.4809	NM_001284302
ANLN	hsa-miR-374a-5p	89.0752	NM_001284302
ANLN	hsa-miR-4418	88.8277	NM_001284301
ANLN	hsa-miR-548j-3p	88.4647	NM_001284302
ANLN	hsa-miR-548ae-3p	88.4647	NM_001284302
ANLN	hsa-miR-548aj-3p	88.4647	NM_001284302
ANLN	hsa-miR-548x-3p	88.4647	NM_001284302
ANLN	hsa-miR-548am-3p	88.4647	NM_001284302
ANLN	hsa-miR-548aq-3p	88.4647	NM_001284302
ANLN	hsa-miR-548ah-3p	88.4647	NM_001284302
ANLN	hsa-miR-1277-5p	88.32	NM_001284302
ANLN	hsa-miR-5003-3p	88.0006	NM_001284302
ANLN	hsa-miR-3919	87.6307	NM_001284302
ANLN	hsa-miR-9-3p	86.3708	NM_001284301
ANLN	hsa-miR-590-3p	86.2225	NM_001284302
ANLN	hsa-miR-374b-5p	85.8255	NM_001284302
ANLN	hsa-miR-503-5p	84.1731	NM_001284301
ANLN	hsa-miR-4678	84.1505	NM_001284301
ANLN	hsa-miR-4511	83.6602	NM_001284302
ANLN	hsa-miR-15a-5p	81.0629	NM_001284301
ANLN	hsa-miR-15b-5p	81.0629	NM_001284301
ANLN	hsa-miR-16-5p	81.0629	NM_001284301
ANLN	hsa-miR-195-5p	81.0629	NM_001284301
ANLN	hsa-miR-6768-3p	80.0626	NM_001284302

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Motifs and transcription factors (TFs) regulating ANLN

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ANLN	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ANLN	transfac_pro__M04950	EGR1 (directAnnotation).
ANLN	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
ANLN	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ANLN	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
ANLN	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ANLN	transfac_pro__M00652	NRF1 (directAnnotation).
ANLN	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
ANLN	transfac_pro__M04866	HDAC2 (directAnnotation).
ANLN	jaspar__MA1122.1	TFDP1 (directAnnotation).
ANLN	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
ANLN	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
ANLN	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ANLN	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."