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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ANKS1A

Summary for ANKS1A

Gene information	Gene symbol	ANKS1A
	Ensembl ID	ENSG00000064999
	Entrez ID	23294
	Gene name	ankyrin repeat and sterile alpha motif domain containing 1A
	Synonyms	ANKS1\|KIAA0229
	Gene type	protein_coding
	UniProtAcc	Q92625

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Dataset with differentially expressed gene: ANKS1A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.323517	0.00e+00

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Expression of ANKS1A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ANKS1A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ANKS1A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ANKS1A	hsa-miR-5681a	97.3108	NM_015245
ANKS1A	hsa-miR-558	96.5109	NM_015245
ANKS1A	hsa-miR-345-3p	96.1446	NM_015245
ANKS1A	hsa-miR-6721-5p	95.9907	NM_015245
ANKS1A	hsa-miR-5699-5p	95.7294	NM_015245
ANKS1A	hsa-miR-1297	93.8345	NM_015245
ANKS1A	hsa-miR-1913	93.7526	NM_015245
ANKS1A	hsa-miR-6748-3p	93.5458	NM_015245
ANKS1A	hsa-miR-92a-1-5p	93.5284	NM_015245
ANKS1A	hsa-miR-26b-5p	93.4548	NM_015245
ANKS1A	hsa-miR-26a-5p	93.4548	NM_015245
ANKS1A	hsa-miR-1324	92.8246	NM_015245
ANKS1A	hsa-miR-5787	92.7737	NM_015245
ANKS1A	hsa-miR-4505	92.7737	NM_015245
ANKS1A	hsa-miR-4465	92.4364	NM_015245
ANKS1A	hsa-miR-545-5p	92.0374	NM_015245
ANKS1A	hsa-miR-548x-3p	92.0108	NM_015245
ANKS1A	hsa-miR-548aj-3p	92.0108	NM_015245
ANKS1A	hsa-miR-4516	91.9684	NM_015245
ANKS1A	hsa-miR-646	91.3458	NM_015245
ANKS1A	hsa-miR-3150b-3p	90.6922	NM_015245
ANKS1A	hsa-miR-4784	90.6922	NM_015245
ANKS1A	hsa-miR-892c-5p	90.1667	NM_015245
ANKS1A	hsa-miR-548bb-3p	90.017	NM_015245
ANKS1A	hsa-miR-548ae-3p	90.017	NM_015245
ANKS1A	hsa-miR-548z	90.017	NM_015245
ANKS1A	hsa-miR-548ac	90.017	NM_015245
ANKS1A	hsa-miR-548h-3p	90.017	NM_015245
ANKS1A	hsa-miR-548am-3p	90.017	NM_015245
ANKS1A	hsa-miR-548aq-3p	90.017	NM_015245
ANKS1A	hsa-miR-548ah-3p	90.017	NM_015245
ANKS1A	hsa-miR-548d-3p	90.017	NM_015245
ANKS1A	hsa-miR-548j-3p	90.017	NM_015245
ANKS1A	hsa-miR-10394-5p	89.8978	NM_015245
ANKS1A	hsa-miR-622	89.5127	NM_015245
ANKS1A	hsa-miR-195-5p	89.2773	NM_015245
ANKS1A	hsa-miR-15a-5p	89.2773	NM_015245
ANKS1A	hsa-miR-16-5p	89.2773	NM_015245
ANKS1A	hsa-miR-15b-5p	89.2773	NM_015245
ANKS1A	hsa-miR-34a-5p	89.0549	NM_015245
ANKS1A	hsa-miR-449a	89.0549	NM_015245
ANKS1A	hsa-miR-26b-3p	88.3705	NM_015245
ANKS1A	hsa-miR-624-5p	88.3622	NM_015245
ANKS1A	hsa-miR-101-3p	88.076	NM_015245
ANKS1A	hsa-miR-4434	87.6458	NM_015245
ANKS1A	hsa-miR-1263	87.2949	NM_015245
ANKS1A	hsa-miR-671-5p	87.2778	NM_015245
ANKS1A	hsa-miR-6734-3p	87.1668	NM_015245
ANKS1A	hsa-miR-3140-5p	86.5184	NM_015245
ANKS1A	hsa-miR-487b-5p	86.3386	NM_015245

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Motifs and transcription factors (TFs) regulating ANKS1A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ANKS1A	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
ANKS1A	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
ANKS1A	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
ANKS1A	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."