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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ANKRD50

Summary for ANKRD50

Gene information	Gene symbol	ANKRD50
	Ensembl ID	ENSG00000151458
	Entrez ID	57182
	Gene name	ankyrin repeat domain containing 50
	Synonyms	KIAA1223
	Gene type	protein_coding
	UniProtAcc	Q9ULJ7

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Dataset with differentially expressed gene: ANKRD50

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.471676	0.00e+00

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Expression of ANKRD50 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ANKRD50

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ANKRD50

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ANKRD50	hsa-miR-4668-5p	98.602	NM_001167882
ANKRD50	hsa-miR-3163	98.3523	NM_020337
ANKRD50	hsa-miR-3145-3p	97.3958	NM_020337
ANKRD50	hsa-miR-3689a-5p	97.1936	NM_020337
ANKRD50	hsa-miR-3689f	97.1936	NM_020337
ANKRD50	hsa-miR-3689b-5p	97.1936	NM_020337
ANKRD50	hsa-miR-3689e	97.1936	NM_020337
ANKRD50	hsa-miR-7154-3p	96.9573	NM_020337
ANKRD50	hsa-miR-10527-5p	96.2395	NM_020337
ANKRD50	hsa-miR-153-5p	95.6892	NM_001167882
ANKRD50	hsa-miR-6073	95.5045	NM_001167882
ANKRD50	hsa-miR-4744	95.1681	NM_001167882
ANKRD50	hsa-miR-5582-5p	95.0306	NM_020337
ANKRD50	hsa-miR-6513-3p	93.7348	NM_020337
ANKRD50	hsa-miR-205-5p	93.0944	NM_020337
ANKRD50	hsa-miR-889-3p	93.0923	NM_020337
ANKRD50	hsa-miR-12128	92.6247	NM_020337
ANKRD50	hsa-miR-4775	92.082	NM_001167882
ANKRD50	hsa-miR-4418	91.6696	NM_001167882
ANKRD50	hsa-miR-3934-3p	90.9297	NM_001167882
ANKRD50	hsa-miR-509-5p	90.8136	NM_001167882
ANKRD50	hsa-miR-509-3-5p	90.8136	NM_001167882
ANKRD50	hsa-miR-6740-3p	90.7752	NM_001167882
ANKRD50	hsa-miR-6835-3p	90.6377	NM_020337
ANKRD50	hsa-miR-4423-3p	89.9498	NM_020337
ANKRD50	hsa-miR-3182	89.463	NM_001167882
ANKRD50	hsa-miR-95-5p	89.3489	NM_001167882
ANKRD50	hsa-miR-4662a-5p	88.8778	NM_020337
ANKRD50	hsa-miR-134-5p	88.839	NM_001167882
ANKRD50	hsa-miR-3118	88.839	NM_001167882
ANKRD50	hsa-miR-3646	88.5924	NM_020337
ANKRD50	hsa-miR-487a-3p	88.2743	NM_020337
ANKRD50	hsa-miR-154-3p	88.2743	NM_020337
ANKRD50	hsa-miR-494-3p	88.0919	NM_020337
ANKRD50	hsa-miR-335-3p	87.9952	NM_020337
ANKRD50	hsa-miR-17-3p	87.7221	NM_020337
ANKRD50	hsa-miR-4319	87.6493	NM_020337
ANKRD50	hsa-miR-17-5p	87.2068	NM_020337
ANKRD50	hsa-miR-106a-5p	87.2068	NM_020337
ANKRD50	hsa-miR-106b-5p	87.2068	NM_020337
ANKRD50	hsa-miR-519d-3p	87.2068	NM_020337
ANKRD50	hsa-miR-20b-5p	87.2068	NM_020337
ANKRD50	hsa-miR-20a-5p	87.2068	NM_020337
ANKRD50	hsa-miR-93-5p	87.2068	NM_020337
ANKRD50	hsa-miR-526b-3p	87.2068	NM_020337
ANKRD50	hsa-miR-6739-3p	86.6876	NM_001167882
ANKRD50	hsa-miR-23a-3p	86.0976	NM_020337
ANKRD50	hsa-miR-23b-3p	86.0976	NM_020337
ANKRD50	hsa-miR-23c	86.0976	NM_020337
ANKRD50	hsa-miR-182-3p	85.9113	NM_001167882

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Motifs and transcription factors (TFs) regulating ANKRD50

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ANKRD50	metacluster_135.11	NR2C2 (directAnnotation).
ANKRD50	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ANKRD50	tfdimers__MD00038	TFAP2C (directAnnotation).
ANKRD50	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ANKRD50	metacluster_7.13	ZFX (directAnnotation).
ANKRD50	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ANKRD50	cisbp__M00968	MTF2 (directAnnotation).
ANKRD50	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ANKRD50	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ANKRD50	cisbp__M00341	PAX6 (directAnnotation).
ANKRD50	metacluster_198.3	ZFP64 (directAnnotation).
ANKRD50	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ANKRD50	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ANKRD50	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ANKRD50	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ANKRD50	cisbp__M00788	ZFY (inferredBy_Orthology).
ANKRD50	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ANKRD50	metacluster_175.1	ZNF283 (directAnnotation).
ANKRD50	hdpi__ZNF304	ZNF304 (directAnnotation).
ANKRD50	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ANKRD50	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ANKRD50	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ANKRD50	transfac_pro__M01199	TRIM28 (directAnnotation).
ANKRD50	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ANKRD50	metacluster_151.2	ZNF23 (directAnnotation).
ANKRD50	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ANKRD50	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ANKRD50	transfac_pro__M03806	ZBTB7C (directAnnotation).
ANKRD50	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."