Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ANKRD22

Summary for ANKRD22

Gene information	Gene symbol	ANKRD22
	Ensembl ID	ENSG00000152766
	Entrez ID	118932
	Gene name	ankyrin repeat domain 22
	Synonyms	MGC22805
	Gene type	protein_coding
	UniProtAcc	Q5VYY1

Top

Dataset with differentially expressed gene: ANKRD22

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.706564	1.15e-25
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.411462	1.80e-09

Top

Expression of ANKRD22 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to ANKRD22

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating ANKRD22

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ANKRD22	hsa-miR-548as-5p	95.5426	NM_144590
ANKRD22	hsa-miR-548ay-5p	94.7508	NM_144590
ANKRD22	hsa-miR-548h-5p	94.7508	NM_144590
ANKRD22	hsa-miR-548bb-5p	94.7508	NM_144590
ANKRD22	hsa-miR-548ae-5p	94.7508	NM_144590
ANKRD22	hsa-miR-548a-5p	94.7508	NM_144590
ANKRD22	hsa-miR-548ak	94.7508	NM_144590
ANKRD22	hsa-miR-548c-5p	94.7508	NM_144590
ANKRD22	hsa-miR-548j-5p	94.7508	NM_144590
ANKRD22	hsa-miR-548ad-5p	94.7508	NM_144590
ANKRD22	hsa-miR-548i	94.7508	NM_144590
ANKRD22	hsa-miR-548d-5p	94.7508	NM_144590
ANKRD22	hsa-miR-548ap-5p	94.7508	NM_144590
ANKRD22	hsa-miR-548o-5p	94.7508	NM_144590
ANKRD22	hsa-miR-548w	94.7508	NM_144590
ANKRD22	hsa-miR-548am-5p	94.7508	NM_144590
ANKRD22	hsa-miR-548b-5p	94.7508	NM_144590
ANKRD22	hsa-miR-548au-5p	94.7508	NM_144590
ANKRD22	hsa-miR-548ab	94.7508	NM_144590
ANKRD22	hsa-miR-548ar-5p	94.7508	NM_144590
ANKRD22	hsa-miR-548y	94.7508	NM_144590
ANKRD22	hsa-miR-559	94.6644	NM_144590
ANKRD22	hsa-miR-548aq-5p	94.3794	NM_144590
ANKRD22	hsa-miR-510-3p	93.1289	NM_144590
ANKRD22	hsa-miR-3686	92.691	NM_144590
ANKRD22	hsa-miR-3119	92.2233	NM_144590
ANKRD22	hsa-miR-3662	89.9031	NM_144590
ANKRD22	hsa-miR-494-3p	89.0208	NM_144590
ANKRD22	hsa-miR-548av-5p	87.8809	NM_144590
ANKRD22	hsa-miR-548k	87.8809	NM_144590
ANKRD22	hsa-miR-8054	87.8809	NM_144590
ANKRD22	hsa-miR-6504-3p	87.469	NM_144590
ANKRD22	hsa-miR-10399-5p	87.469	NM_144590
ANKRD22	hsa-miR-7155-5p	87.3629	NM_144590
ANKRD22	hsa-miR-95-5p	86.9134	NM_144590
ANKRD22	hsa-miR-548l	86.4818	NM_144590
ANKRD22	hsa-miR-3529-3p	82.1203	NM_144590
ANKRD22	hsa-miR-6760-5p	81.2828	NM_144590
ANKRD22	hsa-miR-4699-3p	80.729	NM_144590
ANKRD22	hsa-miR-205-5p	80.1187	NM_144590
ANKRD22	hsa-miR-607	80.0517	NM_144590

Page: 1

Top

Motifs and transcription factors (TFs) regulating ANKRD22

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ANKRD22	transfac_pro__M02080	ISL2 (directAnnotation).
ANKRD22	metacluster_87.4	ZNF667 (directAnnotation).
ANKRD22	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
ANKRD22	transfac_pro__M02082	ISL2 (directAnnotation).
ANKRD22	metacluster_44.20	NKX3-1 (directAnnotation).
ANKRD22	homer__GGAAATTCCC_NFkB-p65-Rel	RELA (inferredBy_Orthology).
ANKRD22	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	FLI1; FOXI1 (directAnnotation).
ANKRD22	transfac_pro__M06027	ZNF891 (directAnnotation).
ANKRD22	transfac_pro__M06013	ZFP69B (directAnnotation).
ANKRD22	tfdimers__MD00295	EBF1; STAT6 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."