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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ANKRD10

Summary for ANKRD10

Gene information	Gene symbol	ANKRD10
	Ensembl ID	ENSG00000088448
	Entrez ID	55608
	Gene name	ankyrin repeat domain 10
	Synonyms	FLJ20093
	Gene type	protein_coding
	UniProtAcc	Q9NXR5

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Dataset with differentially expressed gene: ANKRD10

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.269944	5.18e-44
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.726228	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.763445	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.622428	0.00e+00

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Expression of ANKRD10 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ANKRD10

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ANKRD10

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ANKRD10	hsa-miR-1283	97.4975	NM_017664
ANKRD10	hsa-miR-6859-3p	97.0671	NM_001286721
ANKRD10	hsa-miR-3529-3p	95.855	NM_001286721
ANKRD10	hsa-miR-3613-3p	95.6812	NM_017664
ANKRD10	hsa-miR-3200-3p	93.4275	NM_017664
ANKRD10	hsa-miR-551b-5p	90.5817	NM_017664
ANKRD10	hsa-miR-548am-5p	89.845	NM_017664
ANKRD10	hsa-miR-548a-5p	89.845	NM_017664
ANKRD10	hsa-miR-548j-5p	89.845	NM_017664
ANKRD10	hsa-miR-548b-5p	89.845	NM_017664
ANKRD10	hsa-miR-548aq-5p	89.845	NM_017664
ANKRD10	hsa-miR-548h-5p	89.845	NM_017664
ANKRD10	hsa-miR-548ad-5p	89.845	NM_017664
ANKRD10	hsa-miR-548bb-5p	89.845	NM_017664
ANKRD10	hsa-miR-548ab	89.845	NM_017664
ANKRD10	hsa-miR-548ae-5p	89.845	NM_017664
ANKRD10	hsa-miR-548y	89.845	NM_017664
ANKRD10	hsa-miR-559	89.845	NM_017664
ANKRD10	hsa-miR-548c-5p	89.845	NM_017664
ANKRD10	hsa-miR-548o-5p	89.845	NM_017664
ANKRD10	hsa-miR-548ak	89.845	NM_017664
ANKRD10	hsa-miR-548w	89.845	NM_017664
ANKRD10	hsa-miR-548d-5p	89.845	NM_017664
ANKRD10	hsa-miR-548i	89.845	NM_017664
ANKRD10	hsa-miR-548ap-5p	89.845	NM_017664
ANKRD10	hsa-miR-548au-5p	89.845	NM_017664
ANKRD10	hsa-miR-548as-5p	89.845	NM_017664
ANKRD10	hsa-miR-548ay-5p	89.845	NM_017664
ANKRD10	hsa-miR-548ar-5p	89.845	NM_017664
ANKRD10	hsa-miR-12136	88.265	NM_017664
ANKRD10	hsa-miR-6504-3p	87.7927	NM_001286721
ANKRD10	hsa-miR-10399-5p	87.7927	NM_001286721
ANKRD10	hsa-miR-548n	87.1761	NM_017664
ANKRD10	hsa-miR-664b-3p	86.5043	NM_017664
ANKRD10	hsa-miR-579-3p	86.5043	NM_017664
ANKRD10	hsa-miR-4477a	85.8514	NM_017664
ANKRD10	hsa-miR-4773	85.3982	NM_017664
ANKRD10	hsa-miR-542-3p	85.0187	NM_017664
ANKRD10	hsa-miR-527	84.8377	NM_017664
ANKRD10	hsa-miR-518a-5p	84.8377	NM_017664
ANKRD10	hsa-miR-4517	84.2318	NM_001286721
ANKRD10	hsa-miR-3163	83.7434	NM_017664
ANKRD10	hsa-miR-4642	82.7031	NM_017664
ANKRD10	hsa-miR-651-3p	82.2722	NM_001286721
ANKRD10	hsa-miR-3148	80.7005	NM_001286721
ANKRD10	hsa-miR-3130-3p	80.6685	NM_017664

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Motifs and transcription factors (TFs) regulating ANKRD10

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ANKRD10	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
ANKRD10	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
ANKRD10	hdpi__ETV4	ETV4 (directAnnotation).
ANKRD10	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
ANKRD10	cisbp__M08198	ELF1 (directAnnotation).
ANKRD10	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
ANKRD10	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
ANKRD10	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ANKRD10	transfac_pro__M04826	EP300 (directAnnotation).
ANKRD10	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
ANKRD10	transfac_pro__M00652	NRF1 (directAnnotation).
ANKRD10	transfac_pro__M04866	HDAC2 (directAnnotation).
ANKRD10	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ANKRD10	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
ANKRD10	metacluster_141.2	E2F2; E2F3 (directAnnotation).
ANKRD10	transfac_pro__M01783	SP2 (directAnnotation).
ANKRD10	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ANKRD10	transfac_pro__M01253	CNOT3 (directAnnotation).
ANKRD10	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
ANKRD10	metacluster_7.13	ZFX (directAnnotation).
ANKRD10	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
ANKRD10	cisbp__M00968	MTF2 (directAnnotation).
ANKRD10	transfac_pro__M04817	ZBTB33 (directAnnotation).
ANKRD10	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
ANKRD10	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
ANKRD10	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
ANKRD10	transfac_pro__M07310	SP5 (directAnnotation).
ANKRD10	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
ANKRD10	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ANKRD10	hdpi__HTATIP2	HTATIP2 (directAnnotation).
ANKRD10	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
ANKRD10	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
ANKRD10	transfac_pro__M02089	E2F3 (directAnnotation).
ANKRD10	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."