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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ANKFY1

Summary for ANKFY1

Gene information	Gene symbol	ANKFY1
	Ensembl ID	ENSG00000185722
	Entrez ID	51479
	Gene name	ankyrin repeat and FYVE domain containing 1
	Synonyms	ANKHZN\|BTBD23\|KIAA1255\|RANK-5\|ZFYVE14
	Gene type	protein_coding
	UniProtAcc	Q9P2R3

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Dataset with differentially expressed gene: ANKFY1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.270161	1.54e-18

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Expression of ANKFY1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ANKFY1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ANKFY1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ANKFY1	hsa-miR-4672	96.5231	NM_001257999
ANKFY1	hsa-miR-3910	96.1642	NM_001257999
ANKFY1	hsa-miR-3944-5p	95.1827	NM_001257999
ANKFY1	hsa-miR-3926	94.8806	NM_001257999
ANKFY1	hsa-miR-466	94.6881	NM_001257999
ANKFY1	hsa-miR-7-5p	93.1574	NM_001257999
ANKFY1	hsa-miR-6757-3p	93.0182	NM_001257999
ANKFY1	hsa-miR-106b-5p	92.6382	NM_001257999
ANKFY1	hsa-miR-106a-5p	92.6382	NM_001257999
ANKFY1	hsa-miR-17-5p	92.6382	NM_001257999
ANKFY1	hsa-miR-4423-3p	92.0909	NM_001257999
ANKFY1	hsa-miR-3941	91.8688	NM_001257999
ANKFY1	hsa-miR-20a-5p	90.8784	NM_001257999
ANKFY1	hsa-miR-519d-3p	90.8784	NM_001257999
ANKFY1	hsa-miR-20b-5p	90.8784	NM_001257999
ANKFY1	hsa-miR-526b-3p	90.8784	NM_001257999
ANKFY1	hsa-miR-93-5p	90.8784	NM_001257999
ANKFY1	hsa-miR-570-3p	90.5768	NM_001257999
ANKFY1	hsa-miR-3921	90.5383	NM_001257999
ANKFY1	hsa-miR-4653-5p	90.5383	NM_001257999
ANKFY1	hsa-miR-140-5p	90.2502	NM_001257999
ANKFY1	hsa-miR-4516	89.6714	NM_001257999
ANKFY1	hsa-miR-4753-3p	88.8229	NM_001257999
ANKFY1	hsa-miR-330-5p	88.6335	NM_001257999
ANKFY1	hsa-miR-519a-3p	88.6203	NM_001257999
ANKFY1	hsa-miR-519c-3p	88.6203	NM_001257999
ANKFY1	hsa-miR-519b-3p	88.6203	NM_001257999
ANKFY1	hsa-miR-326	88.4012	NM_001257999
ANKFY1	hsa-miR-516a-3p	87.8477	NM_001257999
ANKFY1	hsa-miR-516b-3p	87.8477	NM_001257999
ANKFY1	hsa-miR-7162-5p	87.8477	NM_001257999
ANKFY1	hsa-miR-6806-5p	87.6388	NM_001257999
ANKFY1	hsa-miR-155-5p	87.6078	NM_001257999
ANKFY1	hsa-miR-7162-3p	86.2097	NM_001257999
ANKFY1	hsa-miR-4436b-3p	86.2096	NM_001257999
ANKFY1	hsa-miR-6879-5p	86.2096	NM_001257999
ANKFY1	hsa-miR-6735-5p	86.2096	NM_001257999
ANKFY1	hsa-miR-2114-5p	85.7081	NM_001257999
ANKFY1	hsa-miR-5703	85.457	NM_001257999
ANKFY1	hsa-miR-4434	85.457	NM_001257999
ANKFY1	hsa-miR-877-5p	84.9809	NM_001257999
ANKFY1	hsa-miR-548s	84.9428	NM_001257999
ANKFY1	hsa-miR-4632-5p	84.6452	NM_001257999
ANKFY1	hsa-miR-7843-5p	84.6452	NM_001257999
ANKFY1	hsa-miR-4753-5p	84.3416	NM_001257999
ANKFY1	hsa-miR-185-5p	84.2645	NM_001257999
ANKFY1	hsa-miR-4306	84.2645	NM_001257999
ANKFY1	hsa-miR-548aw	83.9295	NM_001257999
ANKFY1	hsa-miR-561-3p	83.7357	NM_001257999
ANKFY1	hsa-miR-8087	83.5149	NM_001257999

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Motifs and transcription factors (TFs) regulating ANKFY1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."