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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ANK3

Summary for ANK3

Gene information	Gene symbol	ANK3
	Ensembl ID	ENSG00000151150
	Entrez ID	288
	Gene name	ankyrin 3
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q12955

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Dataset with differentially expressed gene: ANK3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.762345	0.00e+00

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Expression of ANK3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ANK3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ANK3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ANK3	hsa-miR-3680-3p	99.2087	NM_020987
ANK3	hsa-let-7a-3p	99.0477	NM_001149
ANK3	hsa-miR-98-3p	99.0477	NM_001149
ANK3	hsa-let-7b-3p	99.0477	NM_001149
ANK3	hsa-let-7f-1-3p	99.0477	NM_001149
ANK3	hsa-miR-450b-5p	98.9837	NM_001149
ANK3	hsa-miR-300	98.9084	NM_001149
ANK3	hsa-miR-381-3p	98.9084	NM_001149
ANK3	hsa-miR-6875-3p	98.3576	NM_020987
ANK3	hsa-miR-590-3p	97.3854	NM_020987
ANK3	hsa-miR-6815-3p	97.2532	NM_001149
ANK3	hsa-miR-4659a-3p	97.2249	NM_020987
ANK3	hsa-miR-4659b-3p	97.2249	NM_020987
ANK3	hsa-miR-450a-1-3p	96.6642	NM_020987
ANK3	hsa-miR-4778-5p	96.6058	NM_001149
ANK3	hsa-miR-4775	96.2767	NM_020987
ANK3	hsa-miR-4795-3p	96.222	NM_020987
ANK3	hsa-miR-7-1-3p	96.2172	NM_020987
ANK3	hsa-miR-7-2-3p	96.2172	NM_020987
ANK3	hsa-miR-4760-3p	96.1193	NM_020987
ANK3	hsa-miR-4666a-3p	96.0379	NM_001149
ANK3	hsa-miR-6868-5p	95.5996	NM_001149
ANK3	hsa-miR-539-3p	94.899	NM_001149
ANK3	hsa-miR-485-3p	94.8442	NM_001149
ANK3	hsa-miR-3065-5p	94.7616	NM_020987
ANK3	hsa-miR-548aw	94.7097	NM_001149
ANK3	hsa-miR-3120-3p	94.5131	NM_001149
ANK3	hsa-miR-3163	93.8299	NM_001149
ANK3	hsa-miR-5580-3p	93.7705	NM_001149
ANK3	hsa-miR-103a-3p	93.3327	NM_001149
ANK3	hsa-miR-107	93.3327	NM_001149
ANK3	hsa-miR-124-5p	92.9259	NM_020987
ANK3	hsa-miR-545-3p	92.8248	NM_001149
ANK3	hsa-miR-5581-3p	92.7496	NM_001149
ANK3	hsa-miR-6124	92.5216	NM_001149
ANK3	hsa-miR-527	91.8387	NM_001149
ANK3	hsa-miR-518a-5p	91.8387	NM_001149
ANK3	hsa-miR-643	91.7593	NM_020987
ANK3	hsa-miR-448	91.7076	NM_020987
ANK3	hsa-miR-449a	91.4219	NM_001149
ANK3	hsa-miR-34a-5p	91.4219	NM_001149
ANK3	hsa-miR-199b-5p	91.2649	NM_001149
ANK3	hsa-miR-199a-5p	91.2649	NM_001149
ANK3	hsa-miR-5692a	91.2506	NM_001149
ANK3	hsa-miR-302f	91.2398	NM_020987
ANK3	hsa-miR-6805-3p	91.0702	NM_001149
ANK3	hsa-miR-5691	91.0702	NM_001149
ANK3	hsa-miR-34c-5p	91.0319	NM_001149
ANK3	hsa-miR-449b-5p	91.0319	NM_001149
ANK3	hsa-let-7c-3p	90.9609	NM_020987

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Motifs and transcription factors (TFs) regulating ANK3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ANK3	transfac_pro__M05981	ZNF233 (directAnnotation).
ANK3	transfac_pro__M04950	EGR1 (directAnnotation).
ANK3	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
ANK3	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
ANK3	transfac_pro__M05427	ZNF516 (directAnnotation).
ANK3	transfac_pro__M06109	ZNF254 (directAnnotation).
ANK3	metacluster_172.6	CHD2; E2F1 (directAnnotation).
ANK3	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
ANK3	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."