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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: AMT

Summary for AMT

Gene information	Gene symbol	AMT
	Ensembl ID	ENSG00000145020
	Entrez ID	275
	Gene name	aminomethyltransferase
	Synonyms	GCST\|NKH
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: AMT

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.282174	0.00e+00

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Expression of AMT in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AMT

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AMT

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AMT	hsa-miR-6887-5p	95.0012	NM_001164711
AMT	hsa-miR-6795-5p	95.0012	NM_001164711
AMT	hsa-miR-3190-3p	93.2392	NM_001164712
AMT	hsa-miR-4500	93.1522	NM_000481
AMT	hsa-let-7e-5p	91.097	NM_000481
AMT	hsa-miR-98-5p	91.097	NM_000481
AMT	hsa-let-7i-5p	91.097	NM_000481
AMT	hsa-let-7c-5p	91.097	NM_000481
AMT	hsa-let-7f-5p	91.097	NM_000481
AMT	hsa-let-7b-5p	91.097	NM_000481
AMT	hsa-let-7g-5p	91.097	NM_000481
AMT	hsa-let-7a-5p	91.097	NM_000481
AMT	hsa-miR-1289	90.9831	NM_001164712
AMT	hsa-miR-4458	89.6986	NM_000481
AMT	hsa-let-7d-5p	89.6986	NM_000481
AMT	hsa-miR-6721-5p	88.2747	NM_000481
AMT	hsa-miR-4775	85.6691	NM_001164712
AMT	hsa-miR-6731-5p	82.3416	NM_001164712
AMT	hsa-miR-8085	82.3416	NM_001164712
AMT	hsa-miR-6716-5p	80.3725	NM_001164712

Page: 1

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Motifs and transcription factors (TFs) regulating AMT

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
AMT	"5-methyltetrahydrofolic acid"	DB04789	small molecule
AMT	"NADH"	DB00157	small molecule
AMT	"Tetrahydrofolic acid"	DB00116	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."