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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: AMOTL2

Summary for AMOTL2

Gene information	Gene symbol	AMOTL2
	Ensembl ID	ENSG00000114019
	Entrez ID	51421
	Gene name	angiomotin like 2
	Synonyms	LCCP
	Gene type	protein_coding
	UniProtAcc	Q9Y2J4

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Dataset with differentially expressed gene: AMOTL2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.854206	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.311784	5.14e-19
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.306782	1.11e-09
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.610636	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.288014	1.77e-11
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.364078	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.340541	0.00e+00

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Expression of AMOTL2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AMOTL2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AMOTL2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AMOTL2	hsa-miR-24-3p	97.229	NM_001278683
AMOTL2	hsa-miR-7150	95.0508	NM_001278683
AMOTL2	hsa-miR-6716-5p	93.9088	NM_001278683
AMOTL2	hsa-miR-149-5p	91.4706	NM_001278683
AMOTL2	hsa-miR-1277-5p	91.0119	NM_001278683
AMOTL2	hsa-miR-4447	89.5429	NM_001278683
AMOTL2	hsa-miR-9983-3p	88.2686	NM_001278683
AMOTL2	hsa-miR-7853-5p	87.4317	NM_001278683
AMOTL2	hsa-miR-105-5p	87.4317	NM_001278683
AMOTL2	hsa-miR-3182	87.0197	NM_001278683
AMOTL2	hsa-miR-5681a	86.8179	NM_001278683
AMOTL2	hsa-miR-6783-5p	86.0976	NM_001278683
AMOTL2	hsa-miR-4477a	85.9545	NM_001278683
AMOTL2	hsa-miR-4472	85.1177	NM_001278683
AMOTL2	hsa-miR-302a-5p	85.0454	NM_001278683
AMOTL2	hsa-miR-198	84.0104	NM_001278683
AMOTL2	hsa-miR-129-5p	82.8603	NM_001278683
AMOTL2	hsa-miR-3928-3p	81.7296	NM_001278683
AMOTL2	hsa-miR-4690-5p	80.8603	NM_001278683
AMOTL2	hsa-miR-4689	80.5668	NM_001278683
AMOTL2	hsa-miR-4505	80.456	NM_001278683
AMOTL2	hsa-miR-3914	80.1275	NM_001278683

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Motifs and transcription factors (TFs) regulating AMOTL2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AMOTL2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
AMOTL2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
AMOTL2	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
AMOTL2	swissregulon__mm__Atf2	ATF2 (inferredBy_Orthology).
AMOTL2	tfdimers__MD00465	CRX; IKZF1 (directAnnotation).
AMOTL2	tfdimers__MD00490	CDX2; SOX2 (directAnnotation).
AMOTL2	metacluster_22.39	NFE2L2 (directAnnotation).
AMOTL2	metacluster_74.6	HNF1A (directAnnotation).
AMOTL2	transfac_pro__M07260	IKZF1 (directAnnotation).
AMOTL2	metacluster_134.3	FOXA1; FOXA1; FOXC1; FOXG1; FOXG1; FOXI1; FOXJ3; FOXJ3; FOXJ3; FOXK2; FOXL2; FOXO1; FOXO1; FOXO1; FOXO3; FOXO3; FOXO4; FOXO4; FOXO4; FOXP1; FOXP1; FOXP2; FOXP2; FOXP2 (directAnnotation). FOXD1; FOXJ2; FOXJ2; FOXJ3; FOXK1; FOXL2; FOXL2; FOXL2; FOXO1; FOXO3; FOXO3; FOXP2 (inferredBy_Orthology).
AMOTL2	hocomoco__PATZ1_HUMAN.H11MO.1.C	PATZ1 (directAnnotation).
AMOTL2	metacluster_74.19	HNF1A (inferredBy_Orthology).
AMOTL2	metacluster_74.23	HNF1B (inferredBy_Orthology).
AMOTL2	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
AMOTL2	tfdimers__MD00269	CRX; PBX1 (directAnnotation).
AMOTL2	metacluster_22.13	MAFK (inferredBy_Orthology).
AMOTL2	metacluster_74.5	HNF1B (directAnnotation).
AMOTL2	metacluster_171.4	TEAD1; TEAD1; TEAD1; TEAD1; TEAD3; TEAD3; TEAD4; TEAD4; TEAD4; TEAD4 (directAnnotation). TEAD1; TEAD2; TEAD4; TEAD4 (inferredBy_Orthology).
AMOTL2	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
AMOTL2	tfdimers__MD00024	FOXO1; PAX4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."