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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ALG2

Summary for ALG2

Gene information	Gene symbol	ALG2
	Ensembl ID	ENSG00000119523
	Entrez ID	85365
	Gene name	ALG2 alpha-1,3/1,6-mannosyltransferase
	Synonyms	CDG1I\|CDGIi\|FLJ14511\|hALPG2\|NET38
	Gene type	protein_coding
	UniProtAcc	Q9H553

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Dataset with differentially expressed gene: ALG2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.297743	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.439032	1.46e-39

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Expression of ALG2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ALG2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ALG2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ALG2	hsa-miR-4480	96.6845	NM_033087
ALG2	hsa-miR-6733-3p	95.5739	NM_033087
ALG2	hsa-miR-5011-5p	90.7224	NM_033087
ALG2	hsa-miR-1468-3p	90.1088	NM_033087
ALG2	hsa-miR-4683	90.0193	NM_033087
ALG2	hsa-miR-4676-3p	89.9029	NM_033087
ALG2	hsa-miR-892c-3p	89.9029	NM_033087
ALG2	hsa-miR-452-5p	89.9029	NM_033087
ALG2	hsa-miR-4284	89.2593	NM_033087
ALG2	hsa-miR-382-3p	89.1001	NM_033087
ALG2	hsa-miR-5589-3p	88.8116	NM_033087
ALG2	hsa-miR-204-3p	88.8038	NM_033087
ALG2	hsa-miR-4646-5p	88.8038	NM_033087
ALG2	hsa-miR-124-3p	88.1337	NM_033087
ALG2	hsa-miR-506-3p	88.1337	NM_033087
ALG2	hsa-miR-548g-3p	87.3286	NM_033087
ALG2	hsa-miR-29b-2-5p	86.2568	NM_033087
ALG2	hsa-miR-4740-3p	85.8994	NM_033087
ALG2	hsa-miR-1299	83.7202	NM_033087
ALG2	hsa-miR-7162-3p	83.5167	NM_033087
ALG2	hsa-miR-1277-5p	82.0299	NM_033087
ALG2	hsa-miR-323b-5p	82.0265	NM_033087
ALG2	hsa-miR-494-5p	82.0265	NM_033087
ALG2	hsa-miR-410-5p	82.0265	NM_033087
ALG2	hsa-miR-20a-3p	81.707	NM_033087
ALG2	hsa-miR-4786-3p	81.2868	NM_033087

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Motifs and transcription factors (TFs) regulating ALG2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ALG2	transfac_pro__M06035	ZNF749 (directAnnotation).
ALG2	metacluster_52.11	ZNF184 (directAnnotation).
ALG2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."