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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ALDOB

Summary for ALDOB

Gene information	Gene symbol	ALDOB
	Ensembl ID	ENSG00000136872
	Entrez ID	229
	Gene name	aldolase, fructose-bisphosphate B
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P05062

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Dataset with differentially expressed gene: ALDOB

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-2.79098	0.00e+00

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Expression of ALDOB in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ALDOB

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ALDOB

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ALDOB	hsa-miR-4328	96.1643	NM_000035
ALDOB	hsa-miR-3180-5p	95.208	NM_000035
ALDOB	hsa-miR-6809-3p	94.7319	NM_000035
ALDOB	hsa-miR-4775	93.819	NM_000035
ALDOB	hsa-miR-4753-3p	92.8997	NM_000035
ALDOB	hsa-miR-153-5p	90.7947	NM_000035
ALDOB	hsa-miR-5571-5p	90.6302	NM_000035
ALDOB	hsa-miR-3121-3p	90.3855	NM_000035
ALDOB	hsa-miR-2278	86.4008	NM_000035
ALDOB	hsa-miR-195-3p	84.9661	NM_000035
ALDOB	hsa-miR-16-2-3p	84.9661	NM_000035
ALDOB	hsa-miR-3658	84.5868	NM_000035
ALDOB	hsa-miR-29a-5p	81.9044	NM_000035
ALDOB	hsa-miR-302c-5p	81.528	NM_000035
ALDOB	hsa-miR-323b-5p	81.4817	NM_000035
ALDOB	hsa-miR-494-5p	81.4817	NM_000035
ALDOB	hsa-miR-410-5p	81.4817	NM_000035
ALDOB	hsa-miR-9900	80.9372	NM_000035

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Motifs and transcription factors (TFs) regulating ALDOB

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ALDOB	"1,6-Fructose Diphosphate (Linear Form)"	DB02512	small molecule
ALDOB	"Dihydroxyacetone phosphate"	DB04326	small molecule
ALDOB	"sn-glycerol 3-phosphate"	DB02515	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."