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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: AKR1C3

Summary for AKR1C3

Gene information	Gene symbol	AKR1C3
	Ensembl ID	ENSG00000196139
	Entrez ID	8644
	Gene name	aldo-keto reductase family 1 member C3
	Synonyms	DDX\|HAKRB\|HSD17B5\|KIAA0119\|PGFS
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: AKR1C3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.894995	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.718493	2.36e-29
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.955525	2.71e-06
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	post	NK cells	-0.270377	5.38e-33
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.681971	7.78e-28
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Erythrocytes	-0.420914	1.17e-14
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.32771	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.521432	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.482637	2.03e-05
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.670879	0.00e+00

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Expression of AKR1C3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AKR1C3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AKR1C3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AKR1C3	hsa-miR-4698	95.2019	NM_001253908
AKR1C3	hsa-miR-3176	89.6392	NM_001253908
AKR1C3	hsa-miR-3922-3p	88.6234	NM_001253908
AKR1C3	hsa-miR-3944-5p	84.2988	NM_001253909
AKR1C3	hsa-miR-4703-3p	83.2592	NM_001253908
AKR1C3	hsa-miR-551b-5p	82.0858	NM_001253909

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Motifs and transcription factors (TFs) regulating AKR1C3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AKR1C3	metacluster_33.5	MTF1 (inferredBy_Orthology).
AKR1C3	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
AKR1C3	transfac_pro__M06564	ZNF578 (directAnnotation).
AKR1C3	transfac_pro__M05670	ZNF37A (directAnnotation).
AKR1C3	metacluster_172.6	CHD2; E2F1 (directAnnotation).
AKR1C3	transfac_pro__M06347	ZNF782 (directAnnotation).
AKR1C3	taipale_tf_pairs__GCM1_ETV7_NTNNNGGCGGAAGNNNTTCCNNN_CAP_repr	ETV7; GCM1 (directAnnotation).
AKR1C3	tfdimers__MD00127	HOXA13; TFAP2C (directAnnotation).
AKR1C3	metacluster_157.2	ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
AKR1C3	dbtfbs__FEZF1_HEK293_ENCSR827NWO_merged_N1	FEZF1 (directAnnotation).
AKR1C3	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
AKR1C3	taipale_tf_pairs__HOXB2_ETV1_ACCGGAAATGA_CAP	ETV1; HOXB2 (directAnnotation).
AKR1C3	transfac_pro__M05706	ZNF20 (directAnnotation).
AKR1C3	taipale_tf_pairs__HOXD12_ELK3_NTTTAYNNCCGGAARNN_CAP_repr	ELK3; HOXD12 (directAnnotation).
AKR1C3	transfac_pro__M06601	ZNF501 (directAnnotation).
AKR1C3	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
AKR1C3	transfac_pro__M05545	IKZF4 (inferredBy_Orthology).
AKR1C3	metacluster_141.4	GLIS2 (directAnnotation).
AKR1C3	transfac_pro__M04844	MAX (directAnnotation).
AKR1C3	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
AKR1C3	transfac_pro__M06173	ZNF85 (directAnnotation).
AKR1C3	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
AKR1C3	transfac_pro__M05944	ZNF552 (directAnnotation).
AKR1C3	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
AKR1C3	tfdimers__MD00024	FOXO1; PAX4 (directAnnotation).
AKR1C3	taipale_tf_pairs__GCM2_ELK1_NNRNGGGCGGAARTN_CAP	ELK1; GCM2 (directAnnotation).
AKR1C3	hdpi__MYEF2	MYEF2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
AKR1C3	"3-carboxamido-1,3,5(10)-estratrien-17(R)-spiro-2'(5',5'-dimethyl-6'oxo)tetrahydropyran"	DB07700	small molecule
AKR1C3	"Androstenedione"	DB01536	small molecule
AKR1C3	"Flufenamic acid"	DB02266	small molecule
AKR1C3	"Indomethacin"	DB00328	small molecule
AKR1C3	"NADH"	DB00157	small molecule
AKR1C3	"Nicotinamide adenine dinucleotide phosphate"	DB03461	small molecule
AKR1C3	"Olaparib"	DB09074	small molecule
AKR1C3	"Prostaglandin D2"	DB02056	small molecule
AKR1C3	"Rutin"	DB01698	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."