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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: AKR1C2

Summary for AKR1C2

Gene information	Gene symbol	AKR1C2
	Ensembl ID	ENSG00000151632
	Entrez ID	1646
	Gene name	aldo-keto reductase family 1 member C2
	Synonyms	BABP\|DD\|DD2\|DDH2\|HAKRD\|MCDR2\|TDD
	Gene type	protein_coding
	UniProtAcc	P52895

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Dataset with differentially expressed gene: AKR1C2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.74257	3.84e-04
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.880598	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.460642	1.72e-19
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.967137	5.66e-10
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.251274	4.65e-15
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-2.75717	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.342623	1.19e-11
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	1.91963	0.00e+00

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Expression of AKR1C2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AKR1C2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AKR1C2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AKR1C2	hsa-miR-4306	96.2296	NM_205845
AKR1C2	hsa-miR-4644	89.7426	NM_205845
AKR1C2	hsa-miR-185-5p	89.7426	NM_205845
AKR1C2	hsa-miR-4698	87.3241	NM_205845
AKR1C2	hsa-miR-4312	86.7138	NM_205845
AKR1C2	hsa-miR-1226-3p	85.215	NM_205845
AKR1C2	hsa-miR-23c	85.2062	NM_205845
AKR1C2	hsa-miR-23a-3p	85.2062	NM_205845
AKR1C2	hsa-miR-23b-3p	85.2062	NM_205845
AKR1C2	hsa-miR-3145-3p	83.1681	NM_205845
AKR1C2	hsa-miR-889-5p	82.9433	NM_205845
AKR1C2	hsa-miR-3152-3p	81.8292	NM_205845
AKR1C2	hsa-miR-3613-3p	81.6122	NM_205845
AKR1C2	hsa-miR-1304-5p	81.2211	NM_001135241
AKR1C2	hsa-miR-302c-5p	80.9487	NM_205845
AKR1C2	hsa-miR-595	80.5573	NM_205845

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Motifs and transcription factors (TFs) regulating AKR1C2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AKR1C2	swissregulon__hs__ETV6	ETV6 (directAnnotation).
AKR1C2	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
AKR1C2	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
AKR1C2	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
AKR1C2	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
AKR1C2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
AKR1C2	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
AKR1C2	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
AKR1C2	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
AKR1C2	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
AKR1C2	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
AKR1C2	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
AKR1C2	metacluster_22.29	NFE2 (directAnnotation).
AKR1C2	metacluster_22.25	NFE2L2 (directAnnotation).
AKR1C2	metacluster_2.7	IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology).
AKR1C2	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
AKR1C2	metacluster_22.18	BACH2 (inferredBy_Orthology).
AKR1C2	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
AKR1C2	metacluster_22.32	NFE2L2 (directAnnotation).
AKR1C2	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
AKR1C2	metacluster_22.30	NFE2L2 (directAnnotation).
AKR1C2	metacluster_22.17	NFE2 (directAnnotation).
AKR1C2	metacluster_22.19	NFE2 (directAnnotation).
AKR1C2	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
AKR1C2	metacluster_22.34	BACH2 (directAnnotation).
AKR1C2	metacluster_22.28	BACH1 (directAnnotation).
AKR1C2	metacluster_22.11	NFE2 (directAnnotation).
AKR1C2	metacluster_22.13	MAFK (inferredBy_Orthology).
AKR1C2	metacluster_22.15	BACH1 (directAnnotation).
AKR1C2	metacluster_22.14	BACH1 (inferredBy_Orthology).
AKR1C2	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
AKR1C2	metacluster_22.20	MAFG (directAnnotation).
AKR1C2	metacluster_51.10	HOXA5 (directAnnotation).
AKR1C2	metacluster_22.37	BACH1 (directAnnotation).
AKR1C2	metacluster_51.30	HOXB7 (directAnnotation).
AKR1C2	transfac_pro__M06995	NFE2L3 (directAnnotation).
AKR1C2	metacluster_51.12	PDX1 (directAnnotation).
AKR1C2	metacluster_22.36	BACH2 (directAnnotation).
AKR1C2	metacluster_51.22	MEOX1 (directAnnotation).
AKR1C2	metacluster_51.7	VAX1 (directAnnotation).
AKR1C2	metacluster_51.8	HOXB2 (directAnnotation).
AKR1C2	metacluster_51.9	HOXA2 (directAnnotation).
AKR1C2	metacluster_51.17	HOXB5 (directAnnotation).
AKR1C2	metacluster_51.6	EMX1 (directAnnotation).
AKR1C2	taipale_tf_pairs__HOXA4_RTMATTAN_HT	HOXA4 (directAnnotation).
AKR1C2	metacluster_51.29	HOXD8 (directAnnotation).
AKR1C2	transfac_pro__M06106	ZNF14 (directAnnotation).
AKR1C2	metacluster_51.15	HOXA5 (directAnnotation).
AKR1C2	metacluster_51.19	HOXD4 (directAnnotation).
AKR1C2	metacluster_20.8	MNX1; MNX1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
AKR1C2	"Chenodeoxycholic acid"	DB06777	small molecule
AKR1C2	"Epitestosterone"	DB07768	small molecule
AKR1C2	"NADH"	DB00157	small molecule
AKR1C2	"Nicotinamide adenine dinucleotide phosphate"	DB03461	small molecule
AKR1C2	"Ursodeoxycholic acid"	DB01586	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."