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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: AKAP8

Summary for AKAP8

Gene information	Gene symbol	AKAP8
	Ensembl ID	ENSG00000105127
	Entrez ID	10270
	Gene name	A-kinase anchoring protein 8
	Synonyms	AKAP95\|DKFZp586B1222
	Gene type	protein_coding
	UniProtAcc	O43823

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Dataset with differentially expressed gene: AKAP8

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.386423	2.71e-30
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.26553	1.93e-11

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Expression of AKAP8 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AKAP8

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AKAP8

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AKAP8	hsa-miR-5011-5p	99.9559	NM_005858
AKAP8	hsa-miR-190a-3p	99.9222	NM_005858
AKAP8	hsa-miR-494-3p	98.6818	NM_005858
AKAP8	hsa-miR-651-3p	94.9716	NM_005858
AKAP8	hsa-miR-335-3p	90.0447	NM_005858
AKAP8	hsa-miR-4277	87.5394	NM_005858
AKAP8	hsa-miR-412-3p	83.1143	NM_005858
AKAP8	hsa-miR-3156-5p	82.9938	NM_005858
AKAP8	hsa-miR-3148	82.8716	NM_005858
AKAP8	hsa-miR-520f-5p	82.6202	NM_005858
AKAP8	hsa-miR-6754-3p	82.263	NM_005858
AKAP8	hsa-miR-4477b	82.1382	NM_005858
AKAP8	hsa-miR-939-3p	81.5475	NM_005858
AKAP8	hsa-miR-4308	80.0542	NM_005858

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Motifs and transcription factors (TFs) regulating AKAP8

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AKAP8	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
AKAP8	stark__RCGCMATTW	YY1 (inferredBy_Orthology).
AKAP8	kznf__ZFP57_Imbeault2017_OM_MEME	ZFP57 (directAnnotation).
AKAP8	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
AKAP8	transfac_pro__M04826	EP300 (directAnnotation).
AKAP8	hdpi__ETV4	ETV4 (directAnnotation).
AKAP8	metacluster_141.2	E2F2; E2F3 (directAnnotation).
AKAP8	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
AKAP8	transfac_pro__M04862	NRF1 (directAnnotation).
AKAP8	jaspar__MA0748.2	YY2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."