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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: AKAP10

Summary for AKAP10

Gene information	Gene symbol	AKAP10
	Ensembl ID	ENSG00000108599
	Entrez ID	11216
	Gene name	A-kinase anchoring protein 10
	Synonyms	D-AKAP2\|MGC9414\|PRKA10
	Gene type	protein_coding
	UniProtAcc	O43572

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Dataset with differentially expressed gene: AKAP10

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.275887	0.00e+00

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Expression of AKAP10 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AKAP10

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AKAP10

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AKAP10	hsa-miR-5011-5p	99.9999	NM_007202
AKAP10	hsa-miR-190a-3p	99.9988	NM_007202
AKAP10	hsa-miR-7974	98.1877	NM_007202
AKAP10	hsa-miR-4652-3p	96.5933	NM_007202
AKAP10	hsa-miR-3182	95.2421	NM_007202
AKAP10	hsa-miR-129-5p	95.2008	NM_007202
AKAP10	hsa-miR-9983-3p	94.6248	NM_007202
AKAP10	hsa-miR-5583-3p	91.8821	NM_007202
AKAP10	hsa-miR-4795-5p	90.5992	NM_007202
AKAP10	hsa-miR-1284	89.9421	NM_007202
AKAP10	hsa-miR-630	89.0453	NM_007202
AKAP10	hsa-miR-4261	88.3464	NM_007202
AKAP10	hsa-miR-3121-3p	88.2937	NM_007202
AKAP10	hsa-miR-4687-3p	87.6097	NM_007202
AKAP10	hsa-miR-8062	86.9652	NM_007202
AKAP10	hsa-miR-10226	86.6909	NM_007202
AKAP10	hsa-miR-147b-5p	86.5385	NM_007202
AKAP10	hsa-miR-7976	83.8642	NM_007202
AKAP10	hsa-miR-4743-3p	83.6027	NM_007202
AKAP10	hsa-miR-4633-5p	83.3079	NM_007202
AKAP10	hsa-let-7f-1-3p	82.8191	NM_007202
AKAP10	hsa-miR-548z	81.6525	NM_007202
AKAP10	hsa-miR-548ac	81.6525	NM_007202
AKAP10	hsa-miR-548h-3p	81.6525	NM_007202
AKAP10	hsa-miR-548d-3p	81.6525	NM_007202
AKAP10	hsa-miR-548bb-3p	81.6525	NM_007202
AKAP10	hsa-miR-98-3p	81.0168	NM_007202
AKAP10	hsa-let-7a-3p	81.0168	NM_007202
AKAP10	hsa-let-7b-3p	81.0168	NM_007202
AKAP10	hsa-miR-648	80.9319	NM_007202
AKAP10	hsa-miR-624-5p	80.4122	NM_007202
AKAP10	hsa-miR-339-5p	80.0222	NM_007202

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Motifs and transcription factors (TFs) regulating AKAP10

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AKAP10	jaspar__MA1483.2	ELF2 (directAnnotation).
AKAP10	metacluster_151.2	ZNF23 (directAnnotation).
AKAP10	hdpi__ETV4	ETV4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."