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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: AKAP1

Summary for AKAP1

Gene information	Gene symbol	AKAP1
	Ensembl ID	ENSG00000121057
	Entrez ID	8165
	Gene name	A-kinase anchoring protein 1
	Synonyms	AKAP121\|AKAP149\|AKAP84\|D-AKAP1\|PPP1R43\|PRKA1\|S-AKAP84\|SAKAP84\|TDRD17
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: AKAP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.454735	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.570334	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.281894	0.00e+00

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Expression of AKAP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AKAP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
AKAP1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating AKAP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AKAP1	hsa-let-7c-3p	98.6201	NM_001242902
AKAP1	hsa-miR-148a-3p	98.3161	NM_001242902
AKAP1	hsa-miR-148b-3p	98.3161	NM_001242902
AKAP1	hsa-miR-152-3p	98.3161	NM_001242902
AKAP1	hsa-miR-539-3p	97.2445	NM_003488
AKAP1	hsa-miR-485-3p	97.2445	NM_003488
AKAP1	hsa-miR-199b-5p	96.5194	NM_001242903
AKAP1	hsa-miR-199a-5p	96.5194	NM_001242903
AKAP1	hsa-miR-324-3p	95.9808	NM_001242902
AKAP1	hsa-miR-19b-3p	95.8801	NM_001242902
AKAP1	hsa-miR-19a-3p	95.8801	NM_001242902
AKAP1	hsa-let-7a-2-3p	94.2276	NM_001242902
AKAP1	hsa-let-7g-3p	94.2276	NM_001242902
AKAP1	hsa-miR-3120-3p	93.5268	NM_001242902
AKAP1	hsa-miR-493-5p	91.75	NM_001242902
AKAP1	hsa-miR-642b-5p	90.1169	NM_001242902
AKAP1	hsa-miR-7849-3p	89.6243	NM_001242903
AKAP1	hsa-miR-4699-3p	88.0712	NM_001242902
AKAP1	hsa-miR-454-3p	87.3147	NM_001242902
AKAP1	hsa-miR-204-5p	87.2782	NM_001242902
AKAP1	hsa-miR-211-5p	87.2782	NM_001242902
AKAP1	hsa-miR-7106-3p	86.301	NM_001242902
AKAP1	hsa-miR-6739-3p	86.1982	NM_001242903
AKAP1	hsa-miR-345-3p	85.9451	NM_001242902
AKAP1	hsa-miR-4699-5p	84.0009	NM_001242903
AKAP1	hsa-miR-4709-5p	83.6894	NM_001242902
AKAP1	hsa-miR-548x-3p	83.6229	NM_001242903
AKAP1	hsa-miR-548aj-3p	83.6229	NM_001242903
AKAP1	hsa-miR-3666	83.3029	NM_001242902
AKAP1	hsa-miR-130b-3p	83.3029	NM_001242902
AKAP1	hsa-miR-301a-3p	83.3029	NM_001242902
AKAP1	hsa-miR-130a-3p	83.3029	NM_001242902
AKAP1	hsa-miR-4295	83.3029	NM_001242902
AKAP1	hsa-miR-301b-3p	83.3029	NM_001242902
AKAP1	hsa-miR-12136	82.6986	NM_001242902
AKAP1	hsa-miR-769-5p	82.5789	NM_001242903
AKAP1	hsa-miR-7156-5p	80.6063	NM_001242903
AKAP1	hsa-miR-7150	80.1436	NM_001242902

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Motifs and transcription factors (TFs) regulating AKAP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AKAP1	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
AKAP1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
AKAP1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
AKAP1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
AKAP1	transfac_pro__M06074	ZNF732 (directAnnotation).
AKAP1	jaspar__MA1106.1	HIF1A (directAnnotation).
AKAP1	hocomoco__OTX1_HUMAN.H11MO.0.D	OTX1 (directAnnotation).
AKAP1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
AKAP1	transfac_pro__M07397	ZNF148 (directAnnotation).
AKAP1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
AKAP1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
AKAP1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
AKAP1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
AKAP1	transfac_pro__M01175	ZBTB7B (directAnnotation).
AKAP1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
AKAP1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
AKAP1	transfac_pro__M01303	SP1 (directAnnotation).
AKAP1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
AKAP1	transfac_pro__M02090	E2F4 (directAnnotation).
AKAP1	transfac_pro__M02089	E2F3 (directAnnotation).
AKAP1	metacluster_3.14	WT1; WT1 (directAnnotation).
AKAP1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
AKAP1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
AKAP1	cisbp__M07938	E2F1 (directAnnotation).
AKAP1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
AKAP1	transfac_pro__M07436	WT1 (directAnnotation).
AKAP1	transfac_pro__M02281	SP1 (directAnnotation).
AKAP1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
AKAP1	transfac_pro__M02898	SMAD3 (directAnnotation).
AKAP1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."