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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: AK3

Summary for AK3

Gene information	Gene symbol	AK3
	Ensembl ID	ENSG00000147853
	Entrez ID	50808
	Gene name	adenylate kinase 3
	Synonyms	AK3L1\|AK6\|AKL3L1
	Gene type	protein_coding
	UniProtAcc	Q9UIJ7

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Dataset with differentially expressed gene: AK3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.358036	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.70865	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.292289	1.60e-11
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.381714	0.00e+00

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Expression of AK3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AK3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AK3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AK3	hsa-miR-548n	94.7415	NM_001199852
AK3	hsa-miR-3163	94.4053	NM_001199852
AK3	hsa-miR-8076	93.9313	NM_001199852
AK3	hsa-miR-3688-3p	93.2567	NM_001199852
AK3	hsa-miR-7-5p	92.2765	NM_001199852
AK3	hsa-miR-96-5p	92.1595	NM_001199852
AK3	hsa-miR-302c-5p	90.9345	NM_001199852
AK3	hsa-miR-1271-5p	89.1551	NM_001199852
AK3	hsa-miR-12133	89.1551	NM_001199852
AK3	hsa-miR-548an	89.043	NM_001199852
AK3	hsa-miR-222-5p	87.473	NM_001199852
AK3	hsa-miR-559	87.3074	NM_001199852
AK3	hsa-miR-3119	86.2587	NM_001199852
AK3	hsa-miR-548am-5p	85.2584	NM_001199852
AK3	hsa-miR-548i	85.2584	NM_001199852
AK3	hsa-miR-548w	85.2584	NM_001199852
AK3	hsa-miR-548ad-5p	85.2584	NM_001199852
AK3	hsa-miR-548ay-5p	85.2584	NM_001199852
AK3	hsa-miR-548j-5p	85.2584	NM_001199852
AK3	hsa-miR-548a-5p	85.2584	NM_001199852
AK3	hsa-miR-548ak	85.2584	NM_001199852
AK3	hsa-miR-548ae-5p	85.2584	NM_001199852
AK3	hsa-miR-548b-5p	85.2584	NM_001199852
AK3	hsa-miR-548y	85.2584	NM_001199852
AK3	hsa-miR-548ab	85.2584	NM_001199852
AK3	hsa-miR-548bb-5p	85.2584	NM_001199852
AK3	hsa-miR-548d-5p	85.2584	NM_001199852
AK3	hsa-miR-548ap-5p	85.2584	NM_001199852
AK3	hsa-miR-548aq-5p	85.2584	NM_001199852
AK3	hsa-miR-548as-5p	85.2584	NM_001199852
AK3	hsa-miR-548c-5p	85.2584	NM_001199852
AK3	hsa-miR-548h-5p	85.2584	NM_001199852
AK3	hsa-miR-548au-5p	85.2584	NM_001199852
AK3	hsa-miR-548o-5p	85.2584	NM_001199852
AK3	hsa-miR-548ar-5p	85.2584	NM_001199852
AK3	hsa-miR-3180-5p	85.2003	NM_001199852
AK3	hsa-miR-664b-3p	82.9515	NM_001199852
AK3	hsa-miR-579-3p	82.9515	NM_001199852
AK3	hsa-miR-936	82.3525	NM_001199852
AK3	hsa-miR-4500	82.1463	NM_001199852
AK3	hsa-miR-193b-5p	81.8035	NM_001199852
AK3	hsa-miR-4436b-3p	81.3384	NM_001199852
AK3	hsa-miR-6879-5p	81.3384	NM_001199852
AK3	hsa-miR-6735-5p	81.3384	NM_001199852
AK3	hsa-miR-1283	81.1403	NM_001199852
AK3	hsa-miR-4632-5p	81.0619	NM_001199852
AK3	hsa-miR-7843-5p	81.0619	NM_001199852
AK3	hsa-miR-130a-5p	80.7399	NM_001199852
AK3	hsa-miR-552-5p	80.4949	NM_001199852
AK3	hsa-miR-1285-3p	80.1269	NM_001199852

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Motifs and transcription factors (TFs) regulating AK3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AK3	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
AK3	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
AK3	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
AK3	hdpi__ETV4	ETV4 (directAnnotation).
AK3	cisbp__M02645	ETS1 (directAnnotation).
AK3	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
AK3	transfac_pro__M06156	ZNF75D (directAnnotation).
AK3	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
AK3	jaspar__MA1483.2	ELF2 (directAnnotation).
AK3	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
AK3	cisbp__M08198	ELF1 (directAnnotation).
AK3	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
AK3	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
AK3	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
AK3	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
AK3	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
AK3	metacluster_7.13	ZFX (directAnnotation).
AK3	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
AK3	transfac_pro__M02090	E2F4 (directAnnotation).
AK3	transfac_pro__M01714	KLF15 (directAnnotation).
AK3	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
AK3	transfac_pro__M02089	E2F3 (directAnnotation).
AK3	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
AK3	cisbp__M07938	E2F1 (directAnnotation).
AK3	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
AK3	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
AK3	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
AK3	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
AK3	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
AK3	transfac_pro__M00652	NRF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."