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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: AHI1

Summary for AHI1

Gene information	Gene symbol	AHI1
	Ensembl ID	ENSG00000135541
	Entrez ID	54806
	Gene name	Abelson helper integration site 1
	Synonyms	FLJ20069\|JBTS3\|ORF1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: AHI1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.538893	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.283472	0.00e+00

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Expression of AHI1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AHI1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AHI1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AHI1	hsa-miR-1285-3p	97.7217	NM_001134830
AHI1	hsa-miR-5189-5p	97.7217	NM_001134830
AHI1	hsa-miR-4713-5p	96.9197	NM_001134832
AHI1	hsa-miR-1283	96.8779	NM_017651
AHI1	hsa-miR-6860	96.5663	NM_001134830
AHI1	hsa-miR-612	96.5663	NM_001134830
AHI1	hsa-miR-3187-5p	96.5663	NM_001134830
AHI1	hsa-miR-374a-5p	95.5166	NM_017651
AHI1	hsa-miR-374b-5p	94.9202	NM_017651
AHI1	hsa-miR-4495	90.4972	NM_001134830
AHI1	hsa-miR-513b-5p	90.2613	NM_017651
AHI1	hsa-miR-3973	89.1086	NM_001134832
AHI1	hsa-miR-150-5p	89.0258	NM_001134832
AHI1	hsa-miR-4486	84.2242	NM_001134830
AHI1	hsa-miR-576-5p	84.0681	NM_001134830
AHI1	hsa-miR-3170	83.92	NM_017651
AHI1	hsa-miR-6855-5p	83.4055	NM_017651
AHI1	hsa-miR-3609	82.4127	NM_017651
AHI1	hsa-miR-548ah-5p	82.4127	NM_017651
AHI1	hsa-miR-5692a	82.1036	NM_001134830
AHI1	hsa-miR-378g	81.6967	NM_001134830
AHI1	hsa-miR-7159-3p	81.4522	NM_001134832

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Motifs and transcription factors (TFs) regulating AHI1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AHI1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
AHI1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
AHI1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
AHI1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
AHI1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
AHI1	metacluster_3.14	WT1; WT1 (directAnnotation).
AHI1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
AHI1	cisbp__M07938	E2F1 (directAnnotation).
AHI1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
AHI1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
AHI1	transfac_pro__M07397	ZNF148 (directAnnotation).
AHI1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
AHI1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
AHI1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
AHI1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
AHI1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
AHI1	metacluster_7.13	ZFX (directAnnotation).
AHI1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
AHI1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
AHI1	transfac_pro__M01175	ZBTB7B (directAnnotation).
AHI1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
AHI1	tfdimers__MD00151	CHURC1 (directAnnotation).
AHI1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
AHI1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
AHI1	transfac_pro__M01303	SP1 (directAnnotation).
AHI1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
AHI1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
AHI1	transfac_pro__M02090	E2F4 (directAnnotation).
AHI1	transfac_pro__M01714	KLF15 (directAnnotation).
AHI1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
AHI1	jaspar__MA1122.1	TFDP1 (directAnnotation).
AHI1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
AHI1	transfac_pro__M02089	E2F3 (directAnnotation).
AHI1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
AHI1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
AHI1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
AHI1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
AHI1	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
AHI1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
AHI1	transfac_pro__M07436	WT1 (directAnnotation).
AHI1	transfac_pro__M02281	SP1 (directAnnotation).
AHI1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
AHI1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
AHI1	transfac_pro__M02898	SMAD3 (directAnnotation).
AHI1	transfac_public__M00491	PATZ1 (directAnnotation).
AHI1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
AHI1	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."