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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: AHCYL1

Summary for AHCYL1

Gene information	Gene symbol	AHCYL1
	Ensembl ID	ENSG00000168710
	Entrez ID	10768
	Gene name	adenosylhomocysteinase like 1
	Synonyms	IRBIT\|PPP1R78\|XPVKONA
	Gene type	protein_coding
	UniProtAcc	O43865

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Dataset with differentially expressed gene: AHCYL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.273144	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.272275	1.18e-07
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.522167	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.345944	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.360573	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.606632	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.370166	0.00e+00

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Expression of AHCYL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AHCYL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AHCYL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AHCYL1	hsa-miR-548c-3p	96.8475	NM_006621
AHCYL1	hsa-miR-1276	95.9008	NM_001242673
AHCYL1	hsa-miR-6731-5p	95.6781	NM_006621
AHCYL1	hsa-miR-8085	95.6781	NM_006621
AHCYL1	hsa-miR-143-3p	95.5982	NM_001242673
AHCYL1	hsa-miR-4770	95.5982	NM_001242673
AHCYL1	hsa-miR-6088	94.6849	NM_001242673
AHCYL1	hsa-miR-5584-5p	94.4328	NM_006621
AHCYL1	hsa-miR-6809-5p	93.5912	NM_001242673
AHCYL1	hsa-miR-3148	93.2826	NM_006621
AHCYL1	hsa-miR-31-5p	92.1746	NM_001242673
AHCYL1	hsa-miR-4708-5p	91.5432	NM_001242673
AHCYL1	hsa-miR-2355-5p	91.402	NM_001242673
AHCYL1	hsa-miR-942-3p	91.1573	NM_001242673
AHCYL1	hsa-miR-146a-3p	91.1449	NM_006621
AHCYL1	hsa-miR-4653-5p	89.3562	NM_006621
AHCYL1	hsa-miR-3921	89.3562	NM_006621
AHCYL1	hsa-miR-182-5p	88.469	NM_001242673
AHCYL1	hsa-miR-301b-5p	88.4646	NM_006621
AHCYL1	hsa-miR-301a-5p	88.4646	NM_006621
AHCYL1	hsa-miR-591	88.4369	NM_001242673
AHCYL1	hsa-miR-382-3p	87.8932	NM_006621
AHCYL1	hsa-miR-6817-3p	87.5672	NM_006621
AHCYL1	hsa-miR-9-3p	86.9252	NM_001242673
AHCYL1	hsa-miR-4668-3p	86.9057	NM_006621
AHCYL1	hsa-miR-137-3p	86.3543	NM_001242673
AHCYL1	hsa-miR-7152-5p	86.2917	NM_006621
AHCYL1	hsa-miR-580-5p	86.0074	NM_006621
AHCYL1	hsa-miR-298	85.9079	NM_006621
AHCYL1	hsa-miR-3159	85.2369	NM_006621
AHCYL1	hsa-miR-4291	84.7718	NM_001242673
AHCYL1	hsa-miR-202-5p	84.5573	NM_001242673
AHCYL1	hsa-miR-4520-2-3p	84.5542	NM_006621
AHCYL1	hsa-miR-2276-5p	84.4013	NM_001242673
AHCYL1	hsa-miR-2276-3p	83.8955	NM_006621
AHCYL1	hsa-miR-646	83.3258	NM_001242673
AHCYL1	hsa-miR-7152-3p	82.3698	NM_001242673
AHCYL1	hsa-miR-33a-5p	81.321	NM_006621
AHCYL1	hsa-miR-33b-5p	81.321	NM_006621
AHCYL1	hsa-miR-1253	80.0905	NM_001242673
AHCYL1	hsa-miR-3158-5p	80.0841	NM_006621

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Motifs and transcription factors (TFs) regulating AHCYL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AHCYL1	metacluster_151.2	ZNF23 (directAnnotation).
AHCYL1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
AHCYL1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
AHCYL1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
AHCYL1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
AHCYL1	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
AHCYL1	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
AHCYL1	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
AHCYL1	transfac_pro__M01861	ATF1 (directAnnotation).
AHCYL1	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
AHCYL1	taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAP	ATF4; CEBPB (directAnnotation).
AHCYL1	metacluster_44.7	NKX3-2 (directAnnotation).
AHCYL1	taipale_tf_pairs__MGA_DLX2_SYAATTANWGGTGYGA_CAP	DLX2; MGA (directAnnotation).
AHCYL1	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
AHCYL1	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
AHCYL1	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
AHCYL1	transfac_pro__M04748	GABPA (directAnnotation).
AHCYL1	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
AHCYL1	transfac_pro__M04950	EGR1 (directAnnotation).
AHCYL1	transfac_pro__M06032	ZNF727 (directAnnotation).
AHCYL1	taipale_tf_pairs__ETV2_FOXI1_RNCGGAANNAAACA_CAP_repr	ETV2; FOXI1 (directAnnotation).
AHCYL1	metacluster_22.29	NFE2 (directAnnotation).
AHCYL1	metacluster_22.25	NFE2L2 (directAnnotation).
AHCYL1	metacluster_2.7	IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology).
AHCYL1	metacluster_22.12	NFE2; NFE2L1 (directAnnotation).
AHCYL1	metacluster_22.18	BACH2 (inferredBy_Orthology).
AHCYL1	metacluster_22.32	NFE2L2 (directAnnotation).
AHCYL1	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
AHCYL1	nitta__nau_TAGGTG20NTGT_KG_NNGTCAGCTGACNN_m1_c3	MYF5; MYF6; MYOD1; MYOG (inferredBy_Orthology).
AHCYL1	metacluster_22.30	NFE2L2 (directAnnotation).
AHCYL1	metacluster_22.17	NFE2 (directAnnotation).
AHCYL1	cisbp__M01725	SREBF2 (inferredBy_Orthology).
AHCYL1	metacluster_22.19	NFE2 (directAnnotation).
AHCYL1	metacluster_22.34	BACH2 (directAnnotation).
AHCYL1	metacluster_22.28	BACH1 (directAnnotation).
AHCYL1	jaspar__MA1562.1	SOX14 (directAnnotation).
AHCYL1	metacluster_22.11	NFE2 (directAnnotation).
AHCYL1	taipale_tf_pairs__CEBPG_ATF4_NNATGAYGCAAT_CAP	ATF4; CEBPG (directAnnotation).
AHCYL1	transfac_pro__M06084	ZNF208 (directAnnotation).
AHCYL1	transfac_pro__M06135	ZNF28 (directAnnotation).
AHCYL1	jaspar__MA1933.1	SREBF2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."