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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: AGO1

Summary for AGO1

Gene information	Gene symbol	AGO1
	Ensembl ID	ENSG00000092847
	Entrez ID	26523
	Gene name	argonaute RISC component 1
	Synonyms	EIF2C1\|hAGO1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: AGO1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mast cells	-0.485427	4.62e-02
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.304491	0.00e+00

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Expression of AGO1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AGO1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AGO1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AGO1	hsa-miR-519a-3p	99.3611	NM_001317123
AGO1	hsa-miR-519b-3p	99.3611	NM_001317123
AGO1	hsa-miR-519c-3p	99.3611	NM_001317123
AGO1	hsa-miR-6086	98.5538	NM_001317123
AGO1	hsa-miR-377-5p	98.5538	NM_001317123
AGO1	hsa-miR-6780a-3p	98.4213	NM_001317123
AGO1	hsa-miR-4659a-3p	97.7392	NM_001317123
AGO1	hsa-miR-4659b-3p	97.7392	NM_001317123
AGO1	hsa-miR-3085-3p	97.4955	NM_001317122
AGO1	hsa-miR-3064-5p	97.4955	NM_001317122
AGO1	hsa-miR-6504-5p	97.4955	NM_001317122
AGO1	hsa-miR-4640-5p	97.4246	NM_001317123
AGO1	hsa-miR-6752-3p	97.4072	NM_001317123
AGO1	hsa-miR-4726-5p	97.2406	NM_001317123
AGO1	hsa-miR-1260a	96.8216	NM_001317123
AGO1	hsa-miR-1260b	96.8216	NM_001317123
AGO1	hsa-miR-12136	95.6478	NM_001317122
AGO1	hsa-miR-138-5p	95.2455	NM_001317123
AGO1	hsa-miR-153-5p	95.1168	NM_001317122
AGO1	hsa-miR-541-3p	95.0479	NM_001317122
AGO1	hsa-miR-654-5p	95.0479	NM_001317122
AGO1	hsa-miR-4515	94.5288	NM_001317122
AGO1	hsa-miR-20a-5p	94.2662	NM_001317123
AGO1	hsa-miR-106b-5p	94.2662	NM_001317123
AGO1	hsa-miR-519d-3p	94.2075	NM_001317123
AGO1	hsa-miR-17-5p	94.2075	NM_001317123
AGO1	hsa-miR-93-5p	94.2075	NM_001317123
AGO1	hsa-miR-20b-5p	94.2075	NM_001317123
AGO1	hsa-miR-106a-5p	94.2075	NM_001317123
AGO1	hsa-miR-3977	93.6741	NM_001317123
AGO1	hsa-miR-511-5p	93.3605	NM_001317122
AGO1	hsa-miR-6734-3p	93.0417	NM_001317122
AGO1	hsa-miR-302e	92.9515	NM_001317123
AGO1	hsa-miR-3148	92.9239	NM_001317122
AGO1	hsa-miR-105-5p	92.8591	NM_001317123
AGO1	hsa-miR-7853-5p	92.8591	NM_001317123
AGO1	hsa-miR-519e-3p	92.667	NM_001317123
AGO1	hsa-miR-515-3p	92.667	NM_001317123
AGO1	hsa-miR-33b-3p	92.667	NM_001317123
AGO1	hsa-miR-1252-5p	92.52	NM_001317122
AGO1	hsa-miR-526b-3p	92.2887	NM_001317123
AGO1	hsa-miR-7162-5p	92.2638	NM_001317123
AGO1	hsa-miR-516b-3p	92.2638	NM_001317123
AGO1	hsa-miR-516a-3p	92.2638	NM_001317123
AGO1	hsa-miR-655-5p	91.936	NM_001317123
AGO1	hsa-miR-371b-3p	91.806	NM_001317123
AGO1	hsa-miR-4441	91.792	NM_001317123
AGO1	hsa-miR-130b-3p	91.7766	NM_001317123
AGO1	hsa-miR-301b-3p	91.7766	NM_001317123
AGO1	hsa-miR-454-3p	91.7766	NM_001317123

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Motifs and transcription factors (TFs) regulating AGO1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AGO1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
AGO1	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
AGO1	transfac_pro__M01973	PLAG1 (directAnnotation).
AGO1	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).
AGO1	taipale_tf_pairs__TFAP2C_ELK1_NGCCTNNGGSNNCGGAAGYN_CAP_repr	ELK1; TFAP2C (directAnnotation).
AGO1	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
AGO1	transfac_pro__M06510	ZFP62 (directAnnotation).
AGO1	transfac_pro__M05523	ZBTB46 (directAnnotation).
AGO1	transfac_pro__M05501	ZBTB8B (directAnnotation).
AGO1	taipale_tf_pairs__FLI1_CEBPB_RNCGGANNTTGCGCAAN_CAP	CEBPB; FLI1 (directAnnotation).
AGO1	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
AGO1	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
AGO1	transfac_pro__M06083	ZNF891 (directAnnotation).
AGO1	metacluster_81.4	FOXN1; FOXN1; FOXN2; FOXN4; FOXR1; PROX1; PROX1 (directAnnotation). FOXN1; FOXN4 (inferredBy_Orthology).
AGO1	transfac_pro__M06568	ZNF501 (directAnnotation).
AGO1	transfac_pro__M04861	SIX5 (directAnnotation).
AGO1	transfac_pro__M06592	ZNF486 (directAnnotation).
AGO1	tfdimers__MD00595	SREBF1; SREBF2; TBP (directAnnotation).
AGO1	swissregulon__mm__Stat4	STAT4 (inferredBy_Orthology).
AGO1	transfac_pro__M05617	ZNF500 (directAnnotation).
AGO1	transfac_pro__M06045	ZNF729 (directAnnotation).
AGO1	swissregulon__hs__ZNF8	ZNF8 (directAnnotation).
AGO1	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."