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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: AFTPH

Summary for AFTPH

Gene information	Gene symbol	AFTPH
	Ensembl ID	ENSG00000119844
	Entrez ID	54812
	Gene name	aftiphilin
	Synonyms	FLJ20080\|FLJ23793\|MGC33965\|Nbla10388
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: AFTPH

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.572961	0.00e+00

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Expression of AFTPH in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AFTPH

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AFTPH

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AFTPH	hsa-miR-3617-5p	98.8133	NM_001002243
AFTPH	hsa-miR-641	98.8133	NM_001002243
AFTPH	hsa-miR-3613-3p	96.8144	NM_001002243
AFTPH	hsa-miR-3140-3p	95.5102	NM_001002243
AFTPH	hsa-miR-205-3p	95.1065	NM_001002243
AFTPH	hsa-miR-576-5p	94.9139	NM_001002243
AFTPH	hsa-miR-548as-3p	94.6853	NM_001002243
AFTPH	hsa-miR-548g-5p	94.3213	NM_001002243
AFTPH	hsa-miR-548f-5p	94.3213	NM_001002243
AFTPH	hsa-miR-548x-5p	94.3213	NM_001002243
AFTPH	hsa-miR-548aj-5p	94.3213	NM_001002243
AFTPH	hsa-miR-1468-3p	93.0798	NM_001002243
AFTPH	hsa-miR-6862-5p	91.9043	NM_001002243
AFTPH	hsa-miR-4253	91.9043	NM_001002243
AFTPH	hsa-miR-3941	91.8618	NM_001002243
AFTPH	hsa-miR-3200-3p	91.7686	NM_001002243
AFTPH	hsa-miR-133a-3p	90.6469	NM_001002243
AFTPH	hsa-miR-133b	90.6469	NM_001002243
AFTPH	hsa-miR-651-3p	90.5028	NM_001002243
AFTPH	hsa-miR-4460	90.1745	NM_001002243
AFTPH	hsa-miR-4703-5p	90.0769	NM_001002243
AFTPH	hsa-miR-4495	89.8587	NM_001002243
AFTPH	hsa-miR-4517	89.7169	NM_001002243
AFTPH	hsa-miR-3202	89.0096	NM_001002243
AFTPH	hsa-miR-8083	88.3701	NM_001002243
AFTPH	hsa-miR-603	88.3338	NM_001002243
AFTPH	hsa-miR-323a-3p	88.2857	NM_001002243
AFTPH	hsa-miR-3942-5p	88.1781	NM_001002243
AFTPH	hsa-miR-12127	87.586	NM_001002243
AFTPH	hsa-miR-22-5p	86.9145	NM_001002243
AFTPH	hsa-miR-3117-3p	85.909	NM_001002243
AFTPH	hsa-miR-587	85.6966	NM_001002243
AFTPH	hsa-miR-548n	85.4919	NM_001002243
AFTPH	hsa-miR-320a-5p	84.26	NM_001002243
AFTPH	hsa-miR-3179	84.0333	NM_001002243
AFTPH	hsa-miR-6895-3p	83.3293	NM_001002243
AFTPH	hsa-miR-6813-3p	82.9993	NM_001002243
AFTPH	hsa-miR-6507-5p	82.7977	NM_001002243
AFTPH	hsa-miR-5699-5p	82.7233	NM_001002243
AFTPH	hsa-miR-3148	82.2432	NM_001002243
AFTPH	hsa-miR-548p	82.1409	NM_001002243
AFTPH	hsa-miR-548ay-5p	81.1487	NM_001002243
AFTPH	hsa-miR-548ak	81.1487	NM_001002243
AFTPH	hsa-miR-548w	81.1487	NM_001002243
AFTPH	hsa-miR-548j-5p	81.1487	NM_001002243
AFTPH	hsa-miR-548aq-5p	81.1487	NM_001002243
AFTPH	hsa-miR-548as-5p	81.1487	NM_001002243
AFTPH	hsa-miR-548c-5p	81.1487	NM_001002243
AFTPH	hsa-miR-548ab	81.1487	NM_001002243
AFTPH	hsa-miR-548y	81.1487	NM_001002243

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Motifs and transcription factors (TFs) regulating AFTPH

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AFTPH	metacluster_135.11	NR2C2 (directAnnotation).
AFTPH	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
AFTPH	tfdimers__MD00038	TFAP2C (directAnnotation).
AFTPH	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
AFTPH	metacluster_7.13	ZFX (directAnnotation).
AFTPH	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
AFTPH	cisbp__M00968	MTF2 (directAnnotation).
AFTPH	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
AFTPH	metacluster_160.20	JUND; PRDM15 (directAnnotation).
AFTPH	cisbp__M00341	PAX6 (directAnnotation).
AFTPH	metacluster_198.3	ZFP64 (directAnnotation).
AFTPH	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
AFTPH	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
AFTPH	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
AFTPH	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
AFTPH	cisbp__M00788	ZFY (inferredBy_Orthology).
AFTPH	metacluster_175.1	ZNF283 (directAnnotation).
AFTPH	hdpi__ZNF304	ZNF304 (directAnnotation).
AFTPH	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
AFTPH	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
AFTPH	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
AFTPH	transfac_pro__M01199	TRIM28 (directAnnotation).
AFTPH	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
AFTPH	metacluster_151.2	ZNF23 (directAnnotation).
AFTPH	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
AFTPH	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
AFTPH	transfac_pro__M03806	ZBTB7C (directAnnotation).
AFTPH	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."