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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: AFF3

Summary for AFF3

Gene information	Gene symbol	AFF3
	Ensembl ID	ENSG00000144218
	Entrez ID	3899
	Gene name	ALF transcription elongation factor 3
	Synonyms	LAF4\|MLLT2-like
	Gene type	protein_coding
	UniProtAcc	P51826

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Dataset with differentially expressed gene: AFF3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.459493	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.274012	2.46e-06
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.909725	3.59e-05

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Expression of AFF3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AFF3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AFF3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AFF3	hsa-miR-6867-5p	99.9761	NM_001025108
AFF3	hsa-miR-493-5p	98.3669	NM_001025108
AFF3	hsa-miR-7160-5p	97.8829	NM_001025108
AFF3	hsa-miR-8485	96.6761	NM_001025108
AFF3	hsa-miR-1283	95.5572	NM_001025108
AFF3	hsa-miR-1208	95.4663	NM_001025108
AFF3	hsa-miR-3613-3p	94.6416	NM_001025108
AFF3	hsa-miR-200c-3p	93.7906	NM_001025108
AFF3	hsa-miR-200b-3p	93.7906	NM_001025108
AFF3	hsa-miR-4709-5p	93.2414	NM_001025108
AFF3	hsa-miR-4443	93.1399	NM_001025108
AFF3	hsa-miR-429	93.0395	NM_001025108
AFF3	hsa-miR-4717-3p	92.9933	NM_001025108
AFF3	hsa-miR-3613-5p	92.9628	NM_001025108
AFF3	hsa-miR-875-3p	92.9497	NM_001025108
AFF3	hsa-miR-4505	92.2481	NM_001025108
AFF3	hsa-miR-5787	91.3946	NM_001025108
AFF3	hsa-miR-450a-2-3p	91.2255	NM_001025108
AFF3	hsa-miR-5696	90.1468	NM_001025108
AFF3	hsa-miR-4663	89.9655	NM_001025108
AFF3	hsa-miR-8077	89.9655	NM_001025108
AFF3	hsa-miR-11399	89.4198	NM_001025108
AFF3	hsa-miR-6807-5p	89.1289	NM_001025108
AFF3	hsa-miR-509-5p	89.0994	NM_001025108
AFF3	hsa-miR-509-3-5p	89.0994	NM_001025108
AFF3	hsa-miR-1277-5p	88.9367	NM_001025108
AFF3	hsa-miR-4418	88.6606	NM_001025108
AFF3	hsa-miR-486-5p	87.4253	NM_001025108
AFF3	hsa-miR-518c-5p	87.3143	NM_001025108
AFF3	hsa-miR-3173-5p	86.1949	NM_001025108
AFF3	hsa-miR-6799-3p	86.1949	NM_001025108
AFF3	hsa-miR-216a-3p	86.1327	NM_001025108
AFF3	hsa-miR-128-3p	86.1327	NM_001025108
AFF3	hsa-miR-4766-5p	85.9514	NM_001025108
AFF3	hsa-miR-548aj-3p	84.7853	NM_001025108
AFF3	hsa-miR-548x-3p	84.7853	NM_001025108
AFF3	hsa-miR-4729	84.4378	NM_001025108
AFF3	hsa-miR-4261	84.1353	NM_001025108
AFF3	hsa-miR-3681-3p	83.9054	NM_001025108
AFF3	hsa-let-7a-3p	83.6644	NM_001025108
AFF3	hsa-miR-98-3p	83.6644	NM_001025108
AFF3	hsa-let-7b-3p	83.6644	NM_001025108
AFF3	hsa-let-7f-1-3p	83.6644	NM_001025108
AFF3	hsa-miR-3915	83.2311	NM_001025108
AFF3	hsa-miR-4679	82.9234	NM_001025108
AFF3	hsa-miR-147b-5p	82.7589	NM_001025108
AFF3	hsa-miR-92b-3p	82.2769	NM_001025108
AFF3	hsa-miR-32-5p	82.2769	NM_001025108
AFF3	hsa-miR-92a-3p	82.2769	NM_001025108
AFF3	hsa-miR-4423-3p	81.9865	NM_001025108

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Motifs and transcription factors (TFs) regulating AFF3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AFF3	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
AFF3	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
AFF3	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
AFF3	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
AFF3	transfac_pro__M04748	GABPA (directAnnotation).
AFF3	swissregulon__hs__ELF2	ELF2 (directAnnotation).
AFF3	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
AFF3	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
AFF3	transfac_public__M00024	E2F1 (directAnnotation).
AFF3	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
AFF3	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
AFF3	transfac_pro__M00652	NRF1 (directAnnotation).
AFF3	metacluster_55.5	ZNF541 (directAnnotation).
AFF3	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
AFF3	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	FLI1; FOXI1 (directAnnotation).
AFF3	metacluster_141.2	E2F2; E2F3 (directAnnotation).
AFF3	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
AFF3	jaspar__MA1935.1	FOXI1 (directAnnotation).
AFF3	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).
AFF3	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
AFF3	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
AFF3	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
AFF3	metacluster_31.7	FOXO1; FOXO3; FOXO6 (directAnnotation).
AFF3	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
AFF3	hdpi__NRL	NRL (directAnnotation).
AFF3	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
AFF3	cisbp__M00968	MTF2 (directAnnotation).
AFF3	hdpi__FEZF2	FEZF2 (directAnnotation).
AFF3	transfac_pro__M07310	SP5 (directAnnotation).
AFF3	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
AFF3	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
AFF3	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
AFF3	metacluster_155.11	SPZ1 (directAnnotation).
AFF3	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
AFF3	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
AFF3	hdpi__HTATIP2	HTATIP2 (directAnnotation).
AFF3	hdpi__HIP2	UBE2K (directAnnotation).
AFF3	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
AFF3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
AFF3	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
AFF3	transfac_pro__M02089	E2F3 (directAnnotation).
AFF3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
AFF3	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."