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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: AFF2

Summary for AFF2

Gene information	Gene symbol	AFF2
	Ensembl ID	ENSG00000155966
	Entrez ID	2334
	Gene name	ALF transcription elongation factor 2
	Synonyms	FMR2\|FRAXE
	Gene type	protein_coding
	UniProtAcc	P51816

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Dataset with differentially expressed gene: AFF2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.868982	0.00e+00

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Expression of AFF2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AFF2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AFF2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AFF2	hsa-miR-6867-5p	99.8899	NM_001169122
AFF2	hsa-miR-6835-3p	98.9324	NM_001169122
AFF2	hsa-miR-579-3p	98.0039	NM_001169122
AFF2	hsa-miR-664b-3p	98.0039	NM_001169122
AFF2	hsa-miR-335-3p	96.909	NM_001169122
AFF2	hsa-miR-4451	96.8051	NM_001169122
AFF2	hsa-miR-196a-1-3p	96.4079	NM_001169122
AFF2	hsa-miR-4802-3p	93.5324	NM_001169122
AFF2	hsa-miR-153-5p	92.7291	NM_001169122
AFF2	hsa-miR-3680-3p	91.9232	NM_001169122
AFF2	hsa-miR-8485	91.1633	NM_001169122
AFF2	hsa-miR-3662	91.1022	NM_001169122
AFF2	hsa-miR-519d-5p	90.9309	NM_001169122
AFF2	hsa-miR-6844	90.792	NM_001169122
AFF2	hsa-miR-5190	89.7207	NM_001169122
AFF2	hsa-miR-3978	89.6979	NM_001169122
AFF2	hsa-miR-4422	88.8822	NM_001169122
AFF2	hsa-miR-4789-5p	88.6789	NM_001169122
AFF2	hsa-miR-4797-5p	88.4618	NM_001169122
AFF2	hsa-miR-5696	88.102	NM_001169122
AFF2	hsa-miR-6733-5p	87.876	NM_001169122
AFF2	hsa-miR-6739-5p	87.876	NM_001169122
AFF2	hsa-miR-3145-3p	87.8551	NM_001169122
AFF2	hsa-miR-3153	86.8753	NM_001169122
AFF2	hsa-miR-4668-3p	86.1134	NM_001169122
AFF2	hsa-miR-5700	86.0682	NM_001169122
AFF2	hsa-miR-26a-1-3p	85.6871	NM_001169122
AFF2	hsa-miR-26a-2-3p	85.6871	NM_001169122
AFF2	hsa-miR-548av-3p	85.2073	NM_001169122
AFF2	hsa-miR-4311	85.0463	NM_001169122
AFF2	hsa-miR-3130-3p	84.3983	NM_001169122
AFF2	hsa-miR-3148	84.3568	NM_001169122
AFF2	hsa-miR-548z	84.2842	NM_001169122
AFF2	hsa-miR-548h-3p	84.2842	NM_001169122
AFF2	hsa-miR-548bb-3p	84.2842	NM_001169122
AFF2	hsa-miR-548ac	84.2842	NM_001169122
AFF2	hsa-miR-548d-3p	84.2842	NM_001169122
AFF2	hsa-miR-22-5p	84.1503	NM_001169122
AFF2	hsa-miR-4769-5p	83.8442	NM_001169122
AFF2	hsa-miR-4500	83.7635	NM_001169122
AFF2	hsa-miR-3529-3p	83.3941	NM_001169122
AFF2	hsa-miR-3074-3p	83.0416	NM_001169122
AFF2	hsa-miR-2355-5p	82.9286	NM_001169122
AFF2	hsa-miR-548c-3p	82.8777	NM_001169122
AFF2	hsa-miR-2052	82.5253	NM_001169122
AFF2	hsa-miR-33a-3p	82.2057	NM_001169122
AFF2	hsa-miR-519e-5p	81.5813	NM_001169122
AFF2	hsa-miR-515-5p	81.5813	NM_001169122
AFF2	hsa-miR-5001-3p	81.0133	NM_001169122
AFF2	hsa-miR-7853-5p	80.9172	NM_001169122

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Motifs and transcription factors (TFs) regulating AFF2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AFF2	hdpi__TP73	TP73 (directAnnotation).
AFF2	metacluster_102.2	ZBED1 (directAnnotation).
AFF2	transfac_pro__M04950	EGR1 (directAnnotation).
AFF2	metacluster_55.5	ZNF541 (directAnnotation).
AFF2	transfac_pro__M04913	ZBTB7A (directAnnotation).
AFF2	taipale__MYBL2_DBD_AACCGTTAACGGNN	MYBL2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."