Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: AFF1

Summary for AFF1

Gene information	Gene symbol	AFF1
	Ensembl ID	ENSG00000172493
	Entrez ID	4299
	Gene name	ALF transcription elongation factor 1
	Synonyms	AF-4\|AF4\|FEL\|MLLT2\|PBM1
	Gene type	protein_coding
	UniProtAcc	P51825

Top

Dataset with differentially expressed gene: AFF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.834252	0.00e+00

Top

Expression of AFF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to AFF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating AFF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AFF1	hsa-miR-5692c	99.9462	NM_001313960
AFF1	hsa-miR-5692b	99.9462	NM_001313960
AFF1	hsa-miR-8485	99.2891	NM_001313960
AFF1	hsa-miR-19b-3p	99.2088	NM_001166693
AFF1	hsa-miR-19a-3p	99.2088	NM_001166693
AFF1	hsa-miR-1277-5p	98.1161	NM_001166693
AFF1	hsa-miR-4775	96.8159	NM_001313960
AFF1	hsa-miR-5683	95.8678	NM_001166693
AFF1	hsa-miR-590-3p	95.5708	NM_001313960
AFF1	hsa-miR-888-5p	95.1023	NM_001313960
AFF1	hsa-miR-483-3p	94.5573	NM_001166693
AFF1	hsa-miR-4659a-3p	94.2401	NM_001313960
AFF1	hsa-miR-4659b-3p	94.2401	NM_001313960
AFF1	hsa-miR-186-5p	94.0648	NM_001313960
AFF1	hsa-miR-651-3p	93.7715	NM_001166693
AFF1	hsa-miR-12125	93.2773	NM_001166693
AFF1	hsa-miR-3120-3p	90.88	NM_001166693
AFF1	hsa-miR-548x-3p	90.8689	NM_001313960
AFF1	hsa-miR-548aj-3p	90.8689	NM_001313960
AFF1	hsa-miR-891a-3p	90.8416	NM_001313960
AFF1	hsa-miR-3163	90.4574	NM_001313960
AFF1	hsa-miR-5582-3p	90.3396	NM_001313960
AFF1	hsa-miR-548am-3p	90.3167	NM_001313960
AFF1	hsa-miR-548ah-3p	90.3167	NM_001313960
AFF1	hsa-miR-548ae-3p	90.3167	NM_001313960
AFF1	hsa-miR-548j-3p	90.3167	NM_001313960
AFF1	hsa-miR-548aq-3p	90.3167	NM_001313960
AFF1	hsa-miR-3119	89.4282	NM_001313960
AFF1	hsa-miR-6740-5p	89.2806	NM_001166693
AFF1	hsa-miR-6502-3p	88.3222	NM_001166693
AFF1	hsa-miR-5011-5p	87.5477	NM_001313960
AFF1	hsa-miR-6882-3p	87.3677	NM_001166693
AFF1	hsa-miR-4279	87.1808	NM_001313960
AFF1	hsa-miR-5193	86.9508	NM_001166693
AFF1	hsa-miR-299-5p	86.322	NM_001313960
AFF1	hsa-miR-4529-5p	86.1855	NM_001313960
AFF1	hsa-miR-103a-1-5p	86.0051	NM_001313960
AFF1	hsa-miR-103a-2-5p	86.0051	NM_001313960
AFF1	hsa-miR-4325	85.9432	NM_001166693
AFF1	hsa-miR-892c-5p	85.913	NM_001166693
AFF1	hsa-miR-25-5p	85.8706	NM_001166693
AFF1	hsa-miR-5680	85.5657	NM_001166693
AFF1	hsa-miR-4323	84.4128	NM_001166693
AFF1	hsa-miR-3978	84.3086	NM_001166693
AFF1	hsa-miR-2115-5p	84.2244	NM_001313960
AFF1	hsa-miR-374a-5p	84.13	NM_001166693
AFF1	hsa-miR-374b-5p	84.021	NM_001166693
AFF1	hsa-miR-6792-3p	83.8637	NM_001313960
AFF1	hsa-miR-4691-5p	83.7469	NM_001313960
AFF1	hsa-miR-92a-3p	83.6723	NM_001166693

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating AFF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
AFF1	metacluster_3.10	KLF2; KLF4 (directAnnotation).
AFF1	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
AFF1	transfac_pro__M01783	SP2 (directAnnotation).
AFF1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
AFF1	cisbp__M00341	PAX6 (directAnnotation).
AFF1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
AFF1	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
AFF1	transfac_pro__M01253	CNOT3 (directAnnotation).
AFF1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
AFF1	metacluster_7.13	ZFX (directAnnotation).
AFF1	cisbp__M00968	MTF2 (directAnnotation).
AFF1	transfac_pro__M04817	ZBTB33 (directAnnotation).
AFF1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
AFF1	transfac_pro__M02089	E2F3 (directAnnotation).
AFF1	jaspar__MA0748.2	YY2 (directAnnotation).
AFF1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
AFF1	taipale_tf_pairs__ERF_PITX1_NSCGGANNNNNNGGMTTA_CAP	ERF; PITX1 (directAnnotation).
AFF1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."