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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: AFAP1L2

Summary for AFAP1L2

Gene information	Gene symbol	AFAP1L2
	Ensembl ID	ENSG00000169129
	Entrez ID	84632
	Gene name	actin filament associated protein 1 like 2
	Synonyms	Em:AC005383.4\|FLJ14564\|KIAA1914\|XB130
	Gene type	protein_coding
	UniProtAcc	Q8N4X5

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Dataset with differentially expressed gene: AFAP1L2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.51169	0.00e+00

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Expression of AFAP1L2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to AFAP1L2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating AFAP1L2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
AFAP1L2	hsa-miR-1827	96.4081	NM_001287824
AFAP1L2	hsa-miR-5683	94.849	NM_001287824
AFAP1L2	hsa-miR-4515	93.8098	NM_001287824
AFAP1L2	hsa-miR-216a-5p	92.7642	NM_001287824
AFAP1L2	hsa-miR-30a-5p	92.7275	NM_001001936
AFAP1L2	hsa-miR-30b-5p	92.7275	NM_001001936
AFAP1L2	hsa-miR-30d-5p	92.7275	NM_001001936
AFAP1L2	hsa-miR-30c-5p	92.7275	NM_001001936
AFAP1L2	hsa-miR-30e-5p	92.7275	NM_001001936
AFAP1L2	hsa-miR-5007-5p	92.2743	NM_001001936
AFAP1L2	hsa-miR-760	91.4883	NM_001287824
AFAP1L2	hsa-miR-548c-3p	91.3142	NM_001287824
AFAP1L2	hsa-miR-302b-5p	91.2498	NM_001287824
AFAP1L2	hsa-miR-302d-5p	91.2498	NM_001287824
AFAP1L2	hsa-miR-924	89.9527	NM_001001936
AFAP1L2	hsa-miR-873-5p	89.8895	NM_001287824
AFAP1L2	hsa-miR-3685	88.4573	NM_001287824
AFAP1L2	hsa-miR-6885-3p	87.8313	NM_001001936
AFAP1L2	hsa-miR-6507-5p	87.6694	NM_001287824
AFAP1L2	hsa-miR-33a-3p	86.295	NM_001001936
AFAP1L2	hsa-miR-4727-3p	85.0663	NM_001287824
AFAP1L2	hsa-miR-10523-5p	83.8254	NM_001287824
AFAP1L2	hsa-miR-3664-3p	83.667	NM_001287824
AFAP1L2	hsa-miR-4533	83.5815	NM_001001936
AFAP1L2	hsa-miR-185-5p	82.7041	NM_001287824
AFAP1L2	hsa-miR-4306	82.7041	NM_001287824
AFAP1L2	hsa-miR-6847-5p	82.5919	NM_001287824
AFAP1L2	hsa-miR-4712-3p	82.2964	NM_001287824

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Motifs and transcription factors (TFs) regulating AFAP1L2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."