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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ADSS2

Summary for ADSS2

Gene information	Gene symbol	ADSS2
	Ensembl ID	ENSG00000035687
	Entrez ID	159
	Gene name	adenylosuccinate synthase 2
	Synonyms	ADSS
	Gene type	protein_coding
	UniProtAcc	P30520

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Dataset with differentially expressed gene: ADSS2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.28831	0.00e+00

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Expression of ADSS2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ADSS2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ADSS2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ADSS2	hsa-miR-302c-5p	99.4516	NM_001126
ADSS2	hsa-miR-196a-1-3p	98.4555	NM_001126
ADSS2	hsa-miR-383-5p	95.0515	NM_001126
ADSS2	hsa-miR-3646	94.9712	NM_001126
ADSS2	hsa-miR-6733-3p	93.1234	NM_001126
ADSS2	hsa-miR-122-5p	93.0475	NM_001126
ADSS2	hsa-miR-922	92.4222	NM_001126
ADSS2	hsa-miR-548av-3p	92.1611	NM_001126
ADSS2	hsa-miR-4803	91.8559	NM_001126
ADSS2	hsa-miR-4291	91.6211	NM_001126
ADSS2	hsa-miR-6892-3p	90.8279	NM_001126
ADSS2	hsa-miR-3529-3p	90.5818	NM_001126
ADSS2	hsa-miR-214-3p	90.2774	NM_001126
ADSS2	hsa-miR-3143	89.9602	NM_001126
ADSS2	hsa-miR-4495	89.2232	NM_001126
ADSS2	hsa-miR-9851-3p	88.6702	NM_001126
ADSS2	hsa-miR-19b-3p	88.1393	NM_001126
ADSS2	hsa-miR-19a-3p	88.1393	NM_001126
ADSS2	hsa-miR-593-5p	87.8326	NM_001126
ADSS2	hsa-miR-891a-3p	87.8071	NM_001126
ADSS2	hsa-miR-548ar-3p	86.9223	NM_001126
ADSS2	hsa-miR-4633-5p	86.2824	NM_001126
ADSS2	hsa-miR-4677-5p	86.1832	NM_001126
ADSS2	hsa-miR-3658	85.8738	NM_001126
ADSS2	hsa-miR-3619-5p	85.8512	NM_001126
ADSS2	hsa-miR-659-3p	85.3298	NM_001126
ADSS2	hsa-miR-4261	85.1764	NM_001126
ADSS2	hsa-miR-548f-3p	85.1112	NM_001126
ADSS2	hsa-miR-548az-3p	85.1112	NM_001126
ADSS2	hsa-miR-548bc	85.1112	NM_001126
ADSS2	hsa-miR-548e-3p	85.1112	NM_001126
ADSS2	hsa-miR-5685	83.9998	NM_001126
ADSS2	hsa-miR-4690-3p	83.9998	NM_001126
ADSS2	hsa-miR-4463	83.8153	NM_001126
ADSS2	hsa-miR-34a-3p	83.1531	NM_001126
ADSS2	hsa-miR-577	83.037	NM_001126
ADSS2	hsa-miR-761	82.5014	NM_001126
ADSS2	hsa-miR-548a-3p	82.4252	NM_001126
ADSS2	hsa-miR-4433b-3p	82.2301	NM_001126
ADSS2	hsa-miR-6853-3p	81.9437	NM_001126
ADSS2	hsa-miR-2115-3p	81.1592	NM_001126
ADSS2	hsa-miR-5683	80.8162	NM_001126
ADSS2	hsa-miR-4257	80.7341	NM_001126

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Motifs and transcription factors (TFs) regulating ADSS2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."