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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ADO

Summary for ADO

Gene information	Gene symbol	ADO
	Ensembl ID	ENSG00000181915
	Entrez ID	84890
	Gene name	2-aminoethanethiol dioxygenase
	Synonyms	C10orf22\|FLJ14547
	Gene type	protein_coding
	UniProtAcc	Q96SZ5

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Dataset with differentially expressed gene: ADO

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.688199	0.00e+00

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Expression of ADO in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ADO

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ADO

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ADO	hsa-miR-6079	96.5195	NM_032804
ADO	hsa-miR-4725-3p	96.2185	NM_032804
ADO	hsa-miR-6780b-5p	96.2185	NM_032804
ADO	hsa-miR-7158-3p	95.8705	NM_032804
ADO	hsa-miR-6828-5p	94.9913	NM_032804
ADO	hsa-miR-4271	94.4511	NM_032804
ADO	hsa-miR-12122	94.37	NM_032804
ADO	hsa-miR-135b-5p	92.9315	NM_032804
ADO	hsa-miR-135a-5p	92.9315	NM_032804
ADO	hsa-miR-548t-5p	92.498	NM_032804
ADO	hsa-miR-548az-5p	92.498	NM_032804
ADO	hsa-miR-34a-5p	92.4637	NM_032804
ADO	hsa-miR-449a	92.4637	NM_032804
ADO	hsa-miR-153-3p	90.9977	NM_032804
ADO	hsa-miR-34c-5p	90.5405	NM_032804
ADO	hsa-miR-449b-5p	90.5405	NM_032804
ADO	hsa-miR-8074	90.3316	NM_032804
ADO	hsa-miR-498-3p	90.2953	NM_032804
ADO	hsa-miR-448	89.9118	NM_032804
ADO	hsa-miR-4263	89.8091	NM_032804
ADO	hsa-miR-137-3p	88.4597	NM_032804
ADO	hsa-miR-6835-3p	88.1685	NM_032804
ADO	hsa-miR-4756-5p	87.9693	NM_032804
ADO	hsa-miR-1321	87.9693	NM_032804
ADO	hsa-miR-4739	87.9693	NM_032804
ADO	hsa-miR-4262	87.623	NM_032804
ADO	hsa-miR-4758-5p	87.3648	NM_032804
ADO	hsa-miR-1238-5p	87.3648	NM_032804
ADO	hsa-miR-6715b-3p	86.9151	NM_032804
ADO	hsa-miR-4804-5p	86.2798	NM_032804
ADO	hsa-miR-197-3p	86.2772	NM_032804
ADO	hsa-miR-218-5p	85.8085	NM_032804
ADO	hsa-miR-335-3p	85.5123	NM_032804
ADO	hsa-miR-889-3p	85.3017	NM_032804
ADO	hsa-miR-671-5p	85.0329	NM_032804
ADO	hsa-miR-4772-3p	83.584	NM_032804
ADO	hsa-miR-181b-5p	83.338	NM_032804
ADO	hsa-miR-181d-5p	83.338	NM_032804
ADO	hsa-miR-181a-5p	83.338	NM_032804
ADO	hsa-miR-181c-5p	83.338	NM_032804
ADO	hsa-miR-30a-5p	82.7287	NM_032804
ADO	hsa-miR-30d-5p	82.7287	NM_032804
ADO	hsa-miR-30e-5p	82.7287	NM_032804
ADO	hsa-miR-30b-5p	82.7287	NM_032804
ADO	hsa-miR-30c-5p	82.7287	NM_032804
ADO	hsa-miR-7706	82.5803	NM_032804
ADO	hsa-miR-9500	82.1704	NM_032804
ADO	hsa-miR-4645-3p	81.317	NM_032804

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Motifs and transcription factors (TFs) regulating ADO

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ADO	metacluster_135.11	NR2C2 (directAnnotation).
ADO	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ADO	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ADO	metacluster_7.13	ZFX (directAnnotation).
ADO	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ADO	cisbp__M00968	MTF2 (directAnnotation).
ADO	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ADO	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ADO	cisbp__M00341	PAX6 (directAnnotation).
ADO	metacluster_198.3	ZFP64 (directAnnotation).
ADO	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ADO	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ADO	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ADO	cisbp__M00788	ZFY (inferredBy_Orthology).
ADO	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ADO	metacluster_175.1	ZNF283 (directAnnotation).
ADO	hdpi__ZNF304	ZNF304 (directAnnotation).
ADO	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ADO	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ADO	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ADO	transfac_pro__M01199	TRIM28 (directAnnotation).
ADO	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ADO	metacluster_151.2	ZNF23 (directAnnotation).
ADO	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ADO	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ADO	transfac_pro__M03806	ZBTB7C (directAnnotation).
ADO	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."