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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ADM

Summary for ADM

Gene information	Gene symbol	ADM
	Ensembl ID	ENSG00000148926
	Entrez ID	133
	Gene name	adrenomedullin
	Synonyms	AM
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ADM

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.319749	3.51e-12
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.747855	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Mono/Macro	0.567849	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.254145	1.78e-09
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.982551	5.00e-15
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	-0.768409	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.27922	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.402989	2.18e-29
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.37023	1.36e-13
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.451791	4.63e-26
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.414874	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	0.929678	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.661268	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.502661	3.14e-31

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Expression of ADM in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ADM

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ADM

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ADM	hsa-miR-1297	97.3692	NM_001124
ADM	hsa-miR-338-5p	97.1413	NM_001124
ADM	hsa-miR-4465	96.855	NM_001124
ADM	hsa-miR-26b-5p	96.8093	NM_001124
ADM	hsa-miR-26a-5p	96.8093	NM_001124
ADM	hsa-miR-365a-3p	96.5259	NM_001124
ADM	hsa-miR-365b-3p	96.5259	NM_001124
ADM	hsa-miR-938	96.372	NM_001124
ADM	hsa-miR-3059-5p	94.9237	NM_001124
ADM	hsa-miR-6886-3p	94.0704	NM_001124
ADM	hsa-miR-4524a-3p	93.9806	NM_001124
ADM	hsa-miR-374c-5p	93.9065	NM_001124
ADM	hsa-miR-655-3p	93.9065	NM_001124
ADM	hsa-miR-4495	93.87	NM_001124
ADM	hsa-miR-3675-3p	92.9007	NM_001124
ADM	hsa-miR-6881-3p	90.3822	NM_001124
ADM	hsa-miR-4325	90.0225	NM_001124
ADM	hsa-miR-3978	89.9612	NM_001124
ADM	hsa-miR-3121-3p	89.2213	NM_001124
ADM	hsa-miR-4670-3p	89.0044	NM_001124
ADM	hsa-miR-4666a-3p	88.7838	NM_001124
ADM	hsa-miR-302f	86.0131	NM_001124
ADM	hsa-miR-7111-3p	84.8898	NM_001124
ADM	hsa-miR-410-3p	84.7815	NM_001124
ADM	hsa-miR-11401	84.2859	NM_001124
ADM	hsa-miR-3924	82.2204	NM_001124
ADM	hsa-miR-6780a-3p	81.6101	NM_001124
ADM	hsa-miR-5697	80.56	NM_001124

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Motifs and transcription factors (TFs) regulating ADM

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ADM	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
ADM	jaspar__MA0079.5	SP1 (directAnnotation).
ADM	transfac_pro__M01714	KLF15 (directAnnotation).
ADM	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ADM	transfac_pro__M04950	EGR1 (directAnnotation).
ADM	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
ADM	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
ADM	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ADM	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
ADM	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
ADM	transfac_pro__M04722	SPI1 (directAnnotation).
ADM	transfac_pro__M02082	ISL2 (directAnnotation).
ADM	metacluster_155.13	ZNF135 (directAnnotation).
ADM	taipale_tf_pairs__TEAD4_ETV4_RCCGGAAATRCC_CAP	ETV4; TEAD4 (directAnnotation).
ADM	jaspar__MA1957.1	ELK1 (directAnnotation).
ADM	metacluster_2.9	IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology).
ADM	tfdimers__MD00208	IRF1; LTF (directAnnotation).
ADM	tfdimers__MD00138	IRF1; IRF2; IRF3; IRF4; IRF5; IRF7; IRF8; IRF9; MYB (directAnnotation).
ADM	taipale_cyt_meth__CDX2_NRTCGTAAANNN_eDBD_meth	CDX2 (directAnnotation).
ADM	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
ADM	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
ADM	taipale_tf_pairs__ETV5_HOXB13_NNCGGANGNNNTWAA_CAP	ETV5; HOXB13 (directAnnotation).
ADM	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).
ADM	metacluster_22.32	NFE2L2 (directAnnotation).
ADM	metacluster_155.29	ZNF2 (directAnnotation). ZNF2 (inferredBy_Orthology).
ADM	metacluster_132.4	MEF2B; MEF2B; MEF2B; MEF2B; MEF2C; MEF2C; MEF2D; MEF2D; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF (directAnnotation). SRF; SRF; SRF; SRF (inferredBy_Orthology).
ADM	taipale_tf_pairs__GCM1_CEBPB_ATRSGGGNNNNTTRCGYAAN_CAP_repr	CEBPB; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."